ID A0A2I0LYP4_COLLI Unreviewed; 198 AA.
AC A0A2I0LYP4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE RecName: Full=Spindle and kinetochore-associated protein 2 {ECO:0000256|ARBA:ARBA00017139};
DE AltName: Full=Protein FAM33A {ECO:0000256|ARBA:ARBA00029651};
GN Name=SKA2 {ECO:0000313|EMBL:PKK22546.1};
GN ORFNames=A306_00008046 {ECO:0000313|EMBL:PKK22546.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK22546.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK22546.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK22546.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|ARBA:ARBA00004186}.
CC -!- SIMILARITY: Belongs to the SKA2 family.
CC {ECO:0000256|ARBA:ARBA00010684}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK22546.1}.
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DR EMBL; AKCR02000061; PKK22546.1; -; Genomic_DNA.
DR RefSeq; XP_005512001.1; XM_005511944.1.
DR AlphaFoldDB; A0A2I0LYP4; -.
DR STRING; 8932.A0A2I0LYP4; -.
DR GeneID; 102093411; -.
DR KEGG; clv:102093411; -.
DR CTD; 348235; -.
DR InParanoid; A0A2I0LYP4; -.
DR OrthoDB; 1382337at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0000940; C:outer kinetochore; IEA:InterPro.
DR GO; GO:0005876; C:spindle microtubule; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:InterPro.
DR Gene3D; 6.10.250.1380; -; 1.
DR InterPro; IPR026762; Ska2.
DR InterPro; IPR042091; Ska2_N.
DR PANTHER; PTHR32017; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2; 1.
DR PANTHER; PTHR32017:SF3; SPINDLE AND KINETOCHORE-ASSOCIATED PROTEIN 2; 1.
DR Pfam; PF16740; SKA2; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 3..85
FT /note="Ska2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF16740"
SQ SEQUENCE 198 AA; 22317 MW; 553EFAC143F02014 CRC64;
MKSLPDNPAE EENPVALLEK LSVVKSRYKT LCMQLEKVSA EQRESMKGIR AALENTMKMV
QALQQHTDLE RFPLSEEEQA AAQQLTCRTA KEMESPADEA FCSGSTIPGS SEESQFKPLT
EEILLTVPRS VRSTVKLADL NNFYRELFNH FVVNKNRAAL SISQMNKMNM KATDSRIQIL
KELAIVELDK QGNVKLIV
//
