ID A0A2I0M0V5_COLLI Unreviewed; 3243 AA.
AC A0A2I0M0V5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Transformation/transcription domain-associated protein {ECO:0000313|EMBL:PKK23308.1};
GN Name=TRRAP {ECO:0000313|EMBL:PKK23308.1};
GN ORFNames=A306_00009162 {ECO:0000313|EMBL:PKK23308.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK23308.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK23308.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK23308.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. TRA1 subfamily.
CC {ECO:0000256|ARBA:ARBA00007234}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK23308.1}.
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DR EMBL; AKCR02000052; PKK23308.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0M0V5; -.
DR InParanoid; A0A2I0M0V5; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0004672; F:protein kinase activity; IEA:UniProt.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 2056..2641
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2884..3207
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3211..3243
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 1410..1437
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1906..1942
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2650..2673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1414..1436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1906..1920
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2653..2672
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3243 AA; 367804 MW; 2A869C1E1CB08441 CRC64;
MQALDIYQVQ IAGNGQTYVR VANCQTVRMK EEKEVLEHFA GVFTMMNPLT FKEIFQTTVP
YMVERISKNY ALQIVANSFL ANPTTSALFA TILVEYLLDR LPEMGSNVEL SNLYLKLFKL
VFGSVSLFAA ENEQMLKPHL HKIVNSSMEL AQTAKEPYNY FLLLRALFRS IGGGSHDLLY
QEFLPLLPNL LQGLNMLQSG LHKQHMKDLF VELCLTVPVR LSSLLPYLPM LMDPLVSALN
GSQTLVSQGL RTLELCVDNL QPDFLYDHIQ PVRAELMQAL WRTLRNPADS ISHVAYRVLG
KFGGSNRKML KESQKLQYVV TEIQGPSITI EFSDCKASIQ LPMEKAIETA LDCLKSANTE
PYYRRQAWEV IKCFLVAMMS LDDNKHALYQ LLAHPNFTEK SIPSVIISHR YKAQDTPARK
TFEQALTGAF MSAVIKDLRP SALPFVASLI RHYTMVAVAQ QCGPFLLQCY QVGSQPSTAM
FHSEENGSKG MDPLVLIDAI AICMAYEEKE LCKIGEVALA VIFDVASIIL GSKERACQLP
LFSYIVERLC ACCYEQAWYA KLGGVVSIKF LMERLPLIWV LQNQQTFLKA LLFVMMDLTG
EVSNGAVAMA KTTLEQLLIR CATPLKDEEK TEEILAAQEK SFHHVTHDLV REVTSPNSTV
RKQAMHSLQV LAQVTGKSVT VIMEPHKEVL QDMVPPKKHL LRHQPANAQI GLMEGNTFCT
TLQPRLFTMD LNVVEHKVFY TELLNLCEAE DTALMKLPCY KSLPSLVPLR IAALNALAAC
NYLPQSREKI IAALFKALNS TNNELQEAGE ACMRKFLEGA TIEVDQIHTH MRPLLMMLGD
YRSLTLNVVN RLTSVTRLFP NSFNDKFCDQ MMQHLRKWME VVVITHKGGQ RSDGNEMKIC
SAIINLFHLI PAAPQTLVKP LLEVVMKTER AMLIEAGSPF REPLIKFLTR HPSQTVELFM
MEATLNDPQW SRMFMSFLKH KDAKPLRDVL AANPNRFITL LLPVGTQAAV RPGSPSTTTM
RLDLQFQAIK IISIIVKNDE CWLANQHSLV NQLKRVWVSE AFQERHRKEN MAATNWKEPK
LLAYCLLNYC KRNYGDIELL FQLLRAFTGR FLCNMTFLKE YMEEEIPKNY SIPQKRALFF
RFVDFNDPNF GDELKAKVLQ HILNPAFLYS FEKGEGEQLL GPPNPEGDNP ESITSVFITK
VLDPEKQADM LDSLRIYLLQ FATLLVEHAP HHIHDNNKNR NSKLRRLMTF AWPCLLSKAC
VDPACKYSGH LLLAHIIAKF AIHKKIVLQV FHSLLKAHAM EARAIVRQAM AILTPAVPAR
MEDGHQMLTH WTRKIIVEEG HTVPQLVHIL HLIVQHFKVY YPVRHHLVQH MVSAMQRLGF
TPSVTIEQRK LAVDLAEVVI KWELQRIKDQ QPDSDMDSSA NGDGPSSASS AVKRGLSVDS
GQEVKRFRTA TGAISAVFGR SQSLPGADAL LSKPIDKQHT DTVVNFLIRI ACQVNDNSNT
AGSPGELLSR RCVNLLKTAL RPDMWPKSEL KLQWFDKLLT TVEQPNQANF ANICTGLRGV
AACMTCGNTK VLRAVHSLLS RLMGIFPTEP STSSVASKYE ELECLYAAVG KVIYEGLTNY
EKATNANPSQ LFGTLMILKS ACSNNPSYID RLISVFMRSL QKMVREHLNP QATAGAAEAN
TAGTSELVML SLDLVKTRLA VMSMEMRKNF IQAILTSLIE KSTDAKILRA VVKIVEEWVK
NNSPMAANQT PTLREKSILL VKMMTYIEKR FPEDLELNAQ FLDLVNYVYR DESLSGSELT
AKLEPAFLSG LRCAQPLIRA KFFEVFDNSM KRRVYERLLY VTCSQNWEAM GNHFWIKQCI
ELLLAVCERN TTIGTSCQGA MLPSITNVIN LADSHDRAAF AMVTHVKQEP RERENSESKE
EDVEIDIELA PGDQTSTPKT KELSEKDIGN QLHMLTNRHD KFLDSLREVK TGALLSAFVQ
LCHISTPLAE KTWIQLFSRL WKILSDRQQH ALAGEISPFL CSGSHQVQRD CQPSALNCFV
EAMSQCVPPI PIRPCVLKYL GKTHNLWFRS TLMLEHQAFE KGLSLQIKPK QTTEFYEQES
ITPPQQEILD SLAELYSLLQ EEDMWAGLWQ KRCKFPETAT AIAYEQHGFF EQAQETYEKA
MEKAKKEHER NNASPSIFPE YQLWEDHWIR CSKELNQWEP LTEYGQSKGH INPYLVLECA
WRVSNWTAMK EALVQVELSC PKEMAWKVNM YRGYLAICHP EEQQLNFIER LVEMASSLAI
REWRRLPHVV SHVHTPLLQA AQQIIELQEA AQINAGLQPT NLGRNNSLHD MKTVVKTWRN
RLPIVSDDLS HWSSIFMWRQ HHYQAIVTAY ENSSQHDPSS NNAMLGVHAS ASAIIQYGKI
ARKQGLVNVA LDILSRIHTI PTVPIVDCFQ KIRQQVKCYL QLAGVMGKNE CMQGLEVIES
TNLKYFTKEM TAEFYALKGM FLAQINKSEE ANKAFSAAVQ MHDVLVKAWA MWGDYLENIF
VKERQLHLGV SAITCYLHAC RHQNESKSRK YLAKVLWLLS FDDDKNTLAD AVDKYCIGVP
PIQWLAWIPQ LLTPGTMALL TSCGHSSSPS TPAFRDVDLI ICVGRVYPQA VYFPIRTLYL
TLKIEQRERY KSDSGQQQPS SVGSQSHSAS DPGPIRATAP MWRCSRIMHM QRELHPTLLS
SLEGIVDQMV WFRENWHEEV LRQLQQGLAK CYSVAFEKSG AVSDAKITPH TLNFVKKLVS
TFGVGLENVS NVSTMFSSAA SESLARRAQA TAQDPVFQKL KGQFTTDFDF SVPGSMKLHN
LISKLKKWIK ILEAKTKQLP KFFLIEEKCR FLSNFSAQTA EVEIPGEFLM PKPTHYYIKI
ARFMPRVEIV QKHNTAARRL YIRGHNGKIY PYLVMNDACL TESRREERVL QLLRLLNPCL
EKRKETTKRH LFFTVPRVVA VSPQMRLVED NPSSLSLVEI YKQRCAKKGI EHDNPISRYY
DRLATVQARG TQASHQVLRD ILKEVQSNMV PRSMLKEWAL HTFPNATDYW TFRKMFTIQL
ALIGFAEFIF HLNRLNPEML QIAQDTGKLN VAYFRFDIND ATGDLDANRP VPFRLTPNIS
EFLTTIGVSG PLTASMIAVA RCFAQPNFKV DGILKTVLRD EIIAWHKKTQ EDTSSPLSAA
GQPENMDSQQ LVSLVQKAVT AIMTRLHNLA QFEGGESKVN TLVAAANSLD NLCRMDPAWH
PWL
//
