ID A0A2I0M116_COLLI Unreviewed; 528 AA.
AC A0A2I0M116;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE RecName: Full=Tyrosinase {ECO:0000256|ARBA:ARBA00039304};
DE EC=1.14.18.1 {ECO:0000256|ARBA:ARBA00011906};
DE AltName: Full=Monophenol monooxygenase {ECO:0000256|ARBA:ARBA00042251};
DE Flags: Fragment;
GN Name=TYR {ECO:0000313|EMBL:PKK23369.1};
GN ORFNames=A306_00011679 {ECO:0000313|EMBL:PKK23369.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK23369.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK23369.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK23369.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- COFACTOR:
CC Name=Cu(2+); Xref=ChEBI:CHEBI:29036;
CC Evidence={ECO:0000256|ARBA:ARBA00001973};
CC -!- SUBCELLULAR LOCATION: Melanosome membrane
CC {ECO:0000256|ARBA:ARBA00004573}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004573}.
CC -!- SIMILARITY: Belongs to the tyrosinase family.
CC {ECO:0000256|ARBA:ARBA00009928}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK23369.1}.
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DR EMBL; AKCR02000051; PKK23369.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0M116; -.
DR STRING; 8932.A0A2I0M116; -.
DR InParanoid; A0A2I0M116; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0033162; C:melanosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0042438; P:melanin biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 1.10.1280.10; Di-copper center containing domain from catechol oxidase; 1.
DR InterPro; IPR008922; Di-copper_centre_dom_sf.
DR InterPro; IPR002227; Tyrosinase_Cu-bd.
DR PANTHER; PTHR11474:SF124; TYROSINASE; 1.
DR PANTHER; PTHR11474; TYROSINASE FAMILY MEMBER; 1.
DR Pfam; PF00264; Tyrosinase; 1.
DR PRINTS; PR00092; TYROSINASE.
DR SUPFAM; SSF48056; Di-copper centre-containing domain; 1.
DR PROSITE; PS00497; TYROSINASE_1; 1.
DR PROSITE; PS00498; TYROSINASE_2; 1.
PE 3: Inferred from homology;
KW Copper {ECO:0000256|ARBA:ARBA00023008};
KW Melanin biosynthesis {ECO:0000256|ARBA:ARBA00023101};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 473..497
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 201..218
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00497"
FT DOMAIN 382..393
FT /note="Tyrosinase copper-binding"
FT /evidence="ECO:0000259|PROSITE:PS00498"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:PKK23369.1"
SQ SEQUENCE 528 AA; 60336 MW; DB4A3046698EA67F CRC64;
ALLLLCEDVS LCHGFSASHP SAVHRTIPQS LCKHTELWDG DGSPCGELSN RGSCQNILLS
QAPLGPQFPF SGVDDREDWP SVFYNRTCKC EGNFMGFNCG ECKFGFSGLN CTERRLRTRR
NIFQLSTTEK NKFLAYLNLA KNIPSQDYVI ATGTYTQMKN GSNPMFRNIN VYDLFVWMHY
YASRDTLLGG SNVWRDIDFA HEAPGFLPWH RVFLLMWERE IQKITGDENF TIPYWDWRDA
EDCVVCTDEY MGGRHPTNPN LLSPASFFSS WQVICTRSEE YNSQQTLCNA TSEGPILRNP
GNNDKSRTPR LPSSAEVEFC LSLTQYESEP MDKMANYSFR NTLEGFADPR TAISNISQSG
LHNALHIYMN GSMSQVQGSA NDPVFVLHHA FVDSIFERWL RRHRPMLEVY PAANAPIGHN
RENYMVPFIP LYRNGEFFKS SRELGYDYEY LQEPALGSFQ EFLIPYLDEA RQIWAWLVGA
AVIGAIITAL LTGLILVCRK KRQRTSSEIQ PLLIESEDYN NMCYQSSF
//
