ID A0A2I0M146_COLLI Unreviewed; 876 AA.
AC A0A2I0M146;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=DNA polymerase kappa {ECO:0000256|ARBA:ARBA00016178};
GN Name=POLK {ECO:0000313|EMBL:PKK23398.1};
GN ORFNames=A306_00009874 {ECO:0000313|EMBL:PKK23398.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK23398.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK23398.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK23398.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK23398.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000050; PKK23398.1; -; Genomic_DNA.
DR RefSeq; XP_005505987.1; XM_005505930.2.
DR AlphaFoldDB; A0A2I0M146; -.
DR GeneID; 102088557; -.
DR CTD; 51426; -.
DR OrthoDB; 146204at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR CDD; cd03586; PolY_Pol_IV_kappa; 1.
DR Gene3D; 1.10.150.810; -; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR HAMAP; MF_01113; DNApol_IV; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR022880; DNApol_IV.
DR InterPro; IPR024728; PolY_HhH_motif.
DR InterPro; IPR006642; Rad18_UBZ4.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR11076:SF33; DNA POLYMERASE KAPPA; 1.
DR PANTHER; PTHR11076; DNA REPAIR POLYMERASE UMUC / TRANSFERASE FAMILY MEMBER; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF11798; IMS_HHH; 1.
DR SMART; SM00734; ZnF_Rad18; 2.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50173; UMUC; 1.
DR PROSITE; PS51908; ZF_UBZ4; 2.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|PROSITE-
KW ProRule:PRU01256};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|PROSITE-
KW ProRule:PRU01256}; DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU01256}.
FT DOMAIN 134..361
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT DOMAIN 622..652
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT DOMAIN 778..808
FT /note="UBZ4-type"
FT /evidence="ECO:0000259|PROSITE:PS51908"
FT REGION 684..731
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 820..876
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 691..731
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 824..864
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 876 AA; 99025 MW; 7FE267BCDCE91BE3 CRC64;
MRCGLVFTAS GQLDLGGIKF YKTYLFSRST VKNMKKVGNS SCSDGFLLRM GLNDNKAGMQ
GLDKEKINKI IMEATKGSRF YENELKKDQQ VNQRIEKMMQ LKEKITTQQL LKAQLQVDKL
VIELEQNRNL SNTIVHIDMD AFYAAVEMRD NPELKEKPIA VGSMSMLSTS NYHARRFGVR
AAMPGFIAKK LCPHLTIVPL NFEKYGKVSK EVREILSEYD PNFMPMGLDE AYLNLTEHLE
ERQNWPEDRR RFFFNTESTT EKVLFEDNTP LMDDDPEQRH QSEENSVVFG NSAEEVVKEI
RFRIEQKTQL TASAGIAPNT MLAKMCSDCN KPNGQYKIPP ERQAVLDFLK DLPIRKVPGI
GKVTEKMLKA LGIVTCSELY QQRALLSLLF SEASWRNFLD ISLGLGSTHL ERDGERKSMS
TERTFSEMNT AEDQYSLCRE LCRDLAQELQ KEGLKGKTVT LKLKNVNFEV KTRASTVLSS
VSTEEEIFAV AKDLLGTEID SVAPHPLRIR LMGVRVSGFL SEEEKKYQQK SITSFLKSGR
EVGFLSLQPG MSNQECFTKN SEASPRGSFF DKKRAARQLN RENFSPNETV GKQPFHDGKS
SAKFVEETKK VTDLQSSNVC KIFTCPVCFE EQSSNNLEEL NRHIDECLNG TFIKDTVEMS
KNNNSGESTL NFLPQVKNEN VDECQKNKKD QLAGSDQSAS TSDKSTSNST DKFTQVISDK
PNRERQPSNL SDMARNVCMK QCLFPMRISQ GSEDHFGKTE HTEETSSSCF FEAKEESVLV
CPVCNSEQKT TSLVSFNRHV DVCLNKGLIQ ELTEKKDFPT KTYNMENSDR VGGLSRGQQC
TNPSQGTKRS GLTASQSVSK KAKSSNSKHT IEKFFK
//
