ID A0A2I0M1S8_COLLI Unreviewed; 803 AA.
AC A0A2I0M1S8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Ras GTPase-activating protein 4 {ECO:0000313|EMBL:PKK23638.1};
GN ORFNames=A306_00008551 {ECO:0000313|EMBL:PKK23638.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK23638.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK23638.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK23638.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK23638.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000048; PKK23638.1; -; Genomic_DNA.
DR RefSeq; XP_013222302.1; XM_013366848.1.
DR AlphaFoldDB; A0A2I0M1S8; -.
DR GeneID; 102095500; -.
DR KEGG; clv:102095500; -.
DR InParanoid; A0A2I0M1S8; -.
DR OrthoDB; 24454at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..105
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 116..233
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 305..513
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 568..675
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 803 AA; 89923 MW; FEE93EE4184DF71B CRC64;
MARRSALSIR IVEGRNLPAK DITGSSDPYC IVKIDDEAII RTATVWKTLS PFWGEEYKVH
LQPTFHSVSI YVMDEDALSR DDVIGKVYIT RDMLVEHPEG YSGWVSLSEV DPDEEVQGEI
HLRVEVQGSQ GGRRLLRCTV LEARDLARKD RNGASDPFVR LRYNGKAQES AVVKKSCYPR
WNETFEFELA EPTEEKLCVE VWDWDLVGRN DFLGKVVFSV QGLEATGQEE GWFRLRPDKS
KPRADERRGS LGSLQLQVRL RDETVLPFPS YQPLVQLLCQ EVKLGRQDGQ VHLVTLLDET
TTAECRQEVA VNLVKLFLGQ GLVKEYLDLL FELELAKPCE PNTLFRSNSL ASKSMESFLK
VTGMPYLHAV LGPTITRVFE EKKYVELDPG KVEIKDVGCS GLHRVQTEGE VIEQGRQHLQ
SYLGELLDAI GRSAPACPLI IRAVFRQLFH RVGERFPQHQ HTKFVAVTSF LCLRFFSPAI
MTPKLFHLRE THADARTSRT LLLLAKAVQL VGNMEPAAGR AKETWLAPLL PALQQGIALM
KDFITRLVGT EREEEEEGEG QPPGPPTMVV KEGLLFVHKT RGKGPVLATA AKKLHFCLSG
DTLSFSKSPS AERSGAIALG DILAAEKVEE KSFGSAHVMQ VVYVDSGGQQ ETAYLQCKCV
NELNQWLSAL RKVCVNNPRV LRTYHPGVFR GDKWSCCHQR EKTGPGCDRT HHGVTLQEWS
DPLDPATEAQ RLYHHLLGLR GTLREKYWEL LEPEDAQNGP RGEGAPLPEG LSRLLGVLGD
LEKCHHLAQP PAPPAPALLQ LQT
//