ID A0A2I0M2P0_COLLI Unreviewed; 2085 AA.
AC A0A2I0M2P0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Teneurin transmembrane protein 4 {ECO:0000313|EMBL:PKK23947.1};
GN Name=TENM4 {ECO:0000313|EMBL:PKK23947.1};
GN ORFNames=A306_00010165 {ECO:0000313|EMBL:PKK23947.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK23947.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK23947.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK23947.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC -!- SIMILARITY: Belongs to the tenascin family. Teneurin subfamily.
CC {ECO:0000256|ARBA:ARBA00009385}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK23947.1}.
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DR EMBL; AKCR02000045; PKK23947.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0M2P0; -.
DR InParanoid; A0A2I0M2P0; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0042995; C:cell projection; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 2.180.10.10; RHS repeat-associated core; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR008969; CarboxyPept-like_regulatory.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR011044; Quino_amine_DH_bsu.
DR InterPro; IPR022385; Rhs_assc_core.
DR InterPro; IPR031325; RHS_repeat.
DR InterPro; IPR028916; Tox-GHH_dom.
DR InterPro; IPR006530; YD.
DR NCBIfam; TIGR03696; Rhs_assc_core; 1.
DR NCBIfam; TIGR01643; YD_repeat_2x; 2.
DR PANTHER; PTHR11219; TENEURIN AND N-ACETYLGLUCOSAMINE-1-PHOSPHODIESTER ALPHA-N-ACETYLGLUCOSAMINIDASE; 1.
DR PANTHER; PTHR11219:SF9; TENEURIN-4; 1.
DR Pfam; PF05593; RHS_repeat; 1.
DR Pfam; PF15636; Tox-GHH; 1.
DR SMART; SM00181; EGF; 2.
DR SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR SUPFAM; SSF50969; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR PROSITE; PS00022; EGF_1; 2.
DR PROSITE; PS01186; EGF_2; 2.
DR PROSITE; PS50026; EGF_3; 2.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000313|EMBL:PKK23947.1};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 72..103
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 112..147
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 76..86
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 93..102
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 116..126
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 137..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2085 AA; 234985 MW; D6808A6261CB15C9 CRC64;
MSLLGRLGRN KLRDPKGHLS GPMFWSWDLP PRHRPLQLRS QLDRTRLLNR DLCSRLRRTR
RLRRGWMGTA CDQRACHPRC NEHGTCRDGK CECSPGWNGE HCTIAHYLDK VVKEGCPGLC
NGNGRCTLDM NGWHCVCQLG WRGAGCDTSM ETACGDGKDN DGDGLVDCMD PDCCLQPLCH
VNALCLGSPD PLDIIQETQA PVSQQSLHSF YDRIKFLIGK DSTHVIPGDN PFEGGHACVI
RGQVMTADGT PLVGVNISFV NNPLFGYTIS RQDGSFDLVT IGGISIILHF ERAPFITQEH
TLWLPWDRFF VMETIVMRHE ENEIPSCDLS NFARPNPVVS PSPLTAFASS CSEKGPIIPE
IQALQEEINV SGSKIKVSYL SSRTAGYKSV LRISMTHPTI PFNLMKVHLM VAVEGRLFRK
WFAAAPDLSY YFIWDKTDVY SQKVYGLSEA FVSVGYEYES CPDLILWEKR TAVLQGYEID
ASKLGGWSLD KHHALNIQSG ILHKGNGENQ FISQQPPVIG SIMGNGRRRS ISCPSCNGLA
DGNKLLAPVA LTCGSDGSLY VGDFNYIRRI FPSGNVTNIL ELRNKDFRHS HSPAHKYYLT
TDPITGSIYL SDTNSRRIYK IKSTTSVKDI VKNAEVLAGT GDQCLPFDDT RCGDGGKGTD
ATLTNPRGIT VDKFGLIYFV DGTMIRRIDQ NGIISTVLGS NDLTSARPLS CDSVMDISQV
RLEWPTDLAV NPMDNSLYVL DNNVVLQISE NHQVRIVAGR PMHCQVPGMD HFLLSKVAIH
ATLESATALA VSHNGILYIA ETDEKKINRI RQVTTNGEIS LVAGAPSSCD CKNDVNCDCF
SGDDGYAKDA KLNAPSSLAV CADGELYVAD LGNIRIRFIR KNKPFLNTQN LYELSSPIDQ
ELYLFDTSGK HLYTQSLTTG DYLYNFTYSG DGDITLITDN NGNLVNIRRD STGMPLWLVV
PDGQVYWVTI GTNSALKSVT TQGHEVAMMT YHGNSGLLAT KSNENGWTTF YEYDSFGRLT
NVTFPTGQVS SFRSDTDSSV HVQVETSSKD DVTITTNLSA SGAFYTLLQD QVRNSYYIGA
DGSLRLMLAN GMEVALQTEP HLLAGTVNPT VGKRNVTLPI DNGLNLVEWR QRKEQARGQV
TVFGRRLRVH NRNLLSLDFD RVTRTEKIYD DHRKFTLRIL YDQAGRPSLW SPSSRLNGVN
VTYSPGGHIA GIQRGTMSER MEYDQSGRIT SRIFADGKSW SYTYLEKSMV LLLHSQRQYI
FEFDKNDRLS SVTMPNVARQ TLETIRSIGY YRNIYRPPEG NASVIQDFTE DEQLLHTLYL
GTGRRVIYKY GKLSKLAEML YDTTKISFTY DETAGMLKTI NLQNEGFTCT IRYRQIGPLI
DRQIFRFTEE GMVNARFDYN YDNSFRVTSM QAVINETPLP IDLYRYDDVS GKTEQFGKFG
VIYYDINQII TTAVMTHTKH FDAYGRMKEV QYEIFRSLMY WMTVQYDNMG RVVKKELKVG
PYANTTRYSY EYDADGQLQT VSINDKPLWR YSYDLNGNLH LLSPGNSARL TPLRYDLRDR
ITRLGDVQYK MDEDGFLKQR GNDIFEYNSA GLLIKAYNKA SGWSVKYRYD GLGRRVSSKT
SHGHHLQFFY ADLTNPTKVT HLYNHSSSEI TSLYYDLQGH LFAMELSSGD EFYIACDNIG
TPLAVFSGTG LMIKQILYTA YGEIYMDTNP NFQIIIGYHG GLYDPLTKLI HMGRRDYDVL
AGRWTSPDHE MWKHLSTNNI MPFNLYMFKN NNPISNSQDI KCYMTDVNSW LLTFGFQLHN
VIPGYPKPDM DAMEPSYELI HTQMKTQEWD NSKSILGVQC EVQKQLKAFV TLERFERIYS
SSIAGCRQVK KNKNFASGGS IFGKGVKFAM KDGRVATDII SVANEDGRRI AAILNNAHYL
ENLHFTIDGV DTHYFIKQGP SEGDLSILGL SGGRRTLENG VNVTVSQINT VLNGRTRRYT
DIQLQYGALC LNTRYGTTLD EEKTRVLELA RQRAVAQAWS REQQRLRDGE EGVRSWTEGE
KQQVLNTGRV QGYDGYFVIS VEQYPELSDS ANNIHFMRQS EMGRR
//
