ID A0A2I0M2Z4_COLLI Unreviewed; 767 AA.
AC A0A2I0M2Z4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Hexose-6-phosphate dehydrogenase (Glucose 1-dehydrogenase) {ECO:0000313|EMBL:PKK24042.1};
GN Name=H6PD {ECO:0000313|EMBL:PKK24042.1};
GN ORFNames=A306_00006122 {ECO:0000313|EMBL:PKK24042.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK24042.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK24042.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK24042.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- PATHWAY: Carbohydrate degradation; pentose phosphate pathway.
CC {ECO:0000256|ARBA:ARBA00004959}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK24042.1}.
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DR EMBL; AKCR02000044; PKK24042.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0M2Z4; -.
DR InParanoid; A0A2I0M2Z4; -.
DR UniPathway; UPA00115; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0017057; F:6-phosphogluconolactonase activity; IEA:InterPro.
DR GO; GO:0004345; F:glucose-6-phosphate dehydrogenase activity; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006006; P:glucose metabolic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-UniPathway.
DR CDD; cd01400; 6PGL; 1.
DR Gene3D; 3.40.50.1360; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005900; 6-phosphogluconolactonase_DevB.
DR InterPro; IPR001282; G6P_DH.
DR InterPro; IPR019796; G6P_DH_AS.
DR InterPro; IPR022675; G6P_DH_C.
DR InterPro; IPR022674; G6P_DH_NAD-bd.
DR InterPro; IPR006148; Glc/Gal-6P_isomerase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR037171; NagB/RpiA_transferase-like.
DR NCBIfam; TIGR01198; pgl; 1.
DR PANTHER; PTHR23429:SF7; GDH_6PGL ENDOPLASMIC BIFUNCTIONAL PROTEIN; 1.
DR PANTHER; PTHR23429; GLUCOSE-6-PHOSPHATE 1-DEHYDROGENASE G6PD; 1.
DR Pfam; PF02781; G6PD_C; 1.
DR Pfam; PF00479; G6PD_N; 1.
DR Pfam; PF01182; Glucosamine_iso; 1.
DR PRINTS; PR00079; G6PDHDRGNASE.
DR SUPFAM; SSF55347; Glyceraldehyde-3-phosphate dehydrogenase-like, C-terminal domain; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF100950; NagB/RpiA/CoA transferase-like; 1.
DR PROSITE; PS00069; G6P_DEHYDROGENASE; 1.
PE 4: Predicted;
KW Carbohydrate metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Glucose metabolism {ECO:0000256|ARBA:ARBA00022526};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..767
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014144446"
FT DOMAIN 29..211
FT /note="Glucose-6-phosphate dehydrogenase NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF00479"
FT DOMAIN 224..500
FT /note="Glucose-6-phosphate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02781"
FT DOMAIN 536..758
FT /note="Glucosamine/galactosamine-6-phosphate isomerase"
FT /evidence="ECO:0000259|Pfam:PF01182"
FT BINDING 208
FT /ligand="substrate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10005"
SQ SEQUENCE 767 AA; 86643 MW; 3D2F8498091992E5 CRC64;
MLRRVLCAVL FVGTLPSLAK GSQGHISVVL LGATGDLAKK YLWQGLFQLY MDQVSSGHSF
TFHGAALTAL EPGQRLMFDV LKKLACPPDE APNRCAVLKD QFLKLSQYHQ LKTAENYTAL
NREIETLLRQ EGLKEAGRIF YFSVPPFAYT EIARHINSSC RPPPGAWLRV VLEKPFGHDL
ESAQQLAAEL TSFFREEEMY RVDHYLGKQA VAHILPFRDQ NRQFLDPIWN XXXLKETVDA
RGRTSFYEQY GVIRDVLQNH LTEALMFLTM ELPANVSRAE EVLQCKLQAF QSLRRLEKSS
AVLGQYQAYA SQVQDELQKA QDYISTTPTF AGVLVHSDNL RWEGVPFLLT SGKALDERVG
YVRVLFKNRA YCTQSETLRD AGHSQCKAKQ IIFYIGHGAL NTPAVLVSRN LFRPVMPEGS
WREAVGQSDL HIFGQPLSDY YVYRPVKERD AYSVLISNIY HGRKDFFITT ENLLASWAFW
TPLLDSISYQ PLRLYPGGVE NQHLLDFEMV SGEVAFTVAE TIQSKFRQSP LVSAWSEDLI
SQLASDIEKT ARRTVAHSGQ FHLALSGGSS PVVLFQRLAR HHYTFPWKHT HIWLVDERCV
PLTDTESNFF SLHNHLLQNI RVPYFNVHPM PVHLNQRLCV EEDRGTELYA KEIVALVANA
SFDLVLLGVG SDGHTASLFP RSDNGLEGVQ AVVLTESPVK PHQRMSLSLP LINKARQVFV
LVLGKGKHDI TTLLSRVGHE PRKWPVSGVS PSSGQLVWYV DYEALLG
//
