ID A0A2I0M3N0_COLLI Unreviewed; 2449 AA.
AC A0A2I0M3N0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=Neurogenic locus notch homolog protein 1 {ECO:0000256|ARBA:ARBA00019142};
GN Name=NOTCH1 {ECO:0000313|EMBL:PKK24282.1};
GN ORFNames=A306_00005931 {ECO:0000313|EMBL:PKK24282.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK24282.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK24282.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK24282.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the NOTCH family.
CC {ECO:0000256|ARBA:ARBA00005847}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK24282.1}.
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DR EMBL; AKCR02000043; PKK24282.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0M3N0; -.
DR InParanoid; A0A2I0M3N0; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR GO; GO:0001525; P:angiogenesis; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0050793; P:regulation of developmental process; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 30.
DR CDD; cd21702; JMTM_Notch1; 1.
DR Gene3D; 3.30.300.320; -; 1.
DR Gene3D; 3.30.70.3310; -; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 2.10.25.10; Laminin; 34.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR008297; Notch.
DR InterPro; IPR035993; Notch-like_dom_sf.
DR InterPro; IPR022362; Notch_1.
DR InterPro; IPR000800; Notch_dom.
DR InterPro; IPR010660; Notch_NOD_dom.
DR InterPro; IPR011656; Notch_NODP_dom.
DR PANTHER; PTHR24044:SF420; NEUROGENIC LOCUS PROTEIN DELTA; 1.
DR PANTHER; PTHR24044; NOTCH LIGAND FAMILY MEMBER; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00008; EGF; 23.
DR Pfam; PF07645; EGF_CA; 3.
DR Pfam; PF12661; hEGF; 5.
DR Pfam; PF06816; NOD; 1.
DR Pfam; PF07684; NODP; 1.
DR Pfam; PF00066; Notch; 3.
DR PIRSF; PIRSF002279; Notch; 1.
DR PRINTS; PR00010; EGFBLOOD.
DR PRINTS; PR01452; LNOTCHREPEAT.
DR PRINTS; PR01983; NOTCH.
DR PRINTS; PR01984; NOTCH1.
DR SMART; SM00248; ANK; 6.
DR SMART; SM00181; EGF; 36.
DR SMART; SM00179; EGF_CA; 33.
DR SMART; SM00004; NL; 3.
DR SMART; SM01338; NOD; 1.
DR SMART; SM01339; NODP; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 20.
DR SUPFAM; SSF57184; Growth factor receptor domain; 5.
DR SUPFAM; SSF90193; Notch domain; 3.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 4.
DR PROSITE; PS00010; ASX_HYDROXYL; 23.
DR PROSITE; PS00022; EGF_1; 34.
DR PROSITE; PS01186; EGF_2; 28.
DR PROSITE; PS50026; EGF_3; 36.
DR PROSITE; PS01187; EGF_CA; 10.
DR PROSITE; PS50258; LNR; 3.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Angiogenesis {ECO:0000256|ARBA:ARBA00022657};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Calcium {ECO:0000256|PIRSR:PIRSR002279-1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Developmental protein {ECO:0000256|ARBA:ARBA00022473};
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR002279-2};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|PIRSR:PIRSR002279-1};
KW Notch signaling pathway {ECO:0000256|ARBA:ARBA00022976};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1729..1750
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 21..60
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 61..101
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 104..141
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 142..178
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 180..218
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 220..257
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 259..295
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 297..328
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 330..366
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 367..405
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 407..445
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 447..483
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 485..521
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 523..559
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 561..596
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 598..634
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 636..671
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 673..709
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 711..746
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 748..784
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 786..822
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 824..862
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 864..900
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 902..938
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 940..976
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 978..1014
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1016..1052
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1054..1090
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1103..1138
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1140..1176
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1178..1214
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1216..1260
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1262..1300
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1302..1341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1343..1379
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1382..1421
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1444..1484
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1485..1526
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT DOMAIN 1527..1566
FT /note="LNR"
FT /evidence="ECO:0000259|PROSITE:PS50258"
FT REPEAT 1922..1954
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 1989..2021
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2022..2054
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 2055..2087
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 1773..1807
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2146..2181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2210..2231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2253..2275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2340..2449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2164..2181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2211..2225
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2340..2424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 427
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 430
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="1"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 447
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 448
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 450
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 464
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 465
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="2"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 485
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 486
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 488
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 502
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT BINDING 503
FT /ligand="Ca(2+)"
FT /ligand_id="ChEBI:CHEBI:29108"
FT /ligand_label="3"
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-1"
FT DISULFID 50..59
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 91..100
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 131..140
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 168..177
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 208..217
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 247..256
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 285..294
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 318..327
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 356..365
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 376..393
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 395..404
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 411..424
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 418..433
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 435..444
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 451..462
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 456..471
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 473..482
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 489..500
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 494..509
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2"
FT DISULFID 511..520
FT /evidence="ECO:0000256|PIRSR:PIRSR002279-2,
FT ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 549..558
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 565..575
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 586..595
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 624..633
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 640..650
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 661..670
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 699..708
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 715..725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 736..745
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 774..783
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 812..821
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 833..850
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 852..861
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 890..899
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 928..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 966..975
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1004..1013
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1042..1051
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1080..1089
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1128..1137
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1166..1175
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1204..1213
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1250..1259
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1271..1288
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1290..1299
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1331..1340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1369..1378
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1411..1420
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 2449 AA; 264900 MW; FBF5322E727EF707 CRC64;
MQLPPLPPRT CAVANTSLLF AGLRCTQLAE SCLNGGKCET FLNGTEVCQC SGAYVGERCQ
LPNPCLSSPC KNAGTCTPVV RGSTVDYTCA CRLGFTDELC LTPRDNVCIS NPCRNGGTCD
LLTLSEYKCR CPPGWSGKTC QQADPCASNP CANGGHCVPF EAHYICRCTA GFHGANCKQD
VNECNISPPV CKNGGSCTNE VGTYQCSCKP AYTGQNCEHL YVPCNPSPCQ NGGTCRQIGD
TTYDCTCLPG FTGQNCEENI NDCPGNNCKN GGTCVDGVNT YNCQCPPEWT GQYCTEDVDE
SRPAPPCHNN HGGYNCVCVN GWTGEDCSEN IDDCAMAACF HGATCHDRVA SFYCECPHGR
TGLLCHLDDA CISNPCNEGS NCDTNPVNGK AICTCPSGYM GPACNQDVDE CSLGANPCEH
AGKCINTQGS FQCQCLQGYS GPRCEIDVNE CLSNPCQNDA TCLDQIGEFQ CICMPGYEGV
YCEINTDECA SSPCLHNGNC LDKINEFHCE CPTGFNGHLC QFDIDECAST PCKNGAKCVD
GPNTYSCECT EGFMGAHCEI DIDECDPDPC HYGTCKDGIA SFTCLCQPGY TGHRCDININ
ECQSQPCKNG GTCQDRNNAY NCLCLKGTTG PNCEINLDDC ASNPCDYGKC IDKINGYECT
CEPGYTGRMC NINIDECSSN PCHNGGTCKD GINGFTCICP EGFHDPKCLS EVNECNSNPC
IHGKCHDGLN GYRCDCDPGW SGTNCDINNN ECESNPCMNG GTCKDMTSGY ICTCREGFSG
PNCQTNINEC ASNPCLNQGT CIDDVAGYTC NCLLPYTGAT CEDVLAPCAG GPCKNGGECR
ESEDYESFSC SCPSGWQGQT CEIDINECVK SPCRNGATCQ NTNGSYRCAC RTGFTGRNCD
TDIDDCKPNP CHNGGSCSDG VGTFFCECLA GFRGPKCEED INECASNPCK NGANCTDCVN
SYTCTCPSGF SGIHCENNTP DCTESSCFNG GTCVDGINTF TCLCPPGFTG SYCEHDINEC
DSKPCLNGGT CQDSYGTYKC TCPQGYTGLN CQNLVRWCDS SPCKNGGKCW QTNNLYRCEC
NSGWTGLYCD VPSVSCEVAA KQQGIDVAHL CRNSGLCVDT GNTHFCRCQA GYTGSYCEEQ
VDECSPNPCQ NGATCTDYLG GYSCECVAGY HGVNCSEEIN ECLSHPCQNG GTCIDLINTY
KCSCPRGTQG VHCEINVDDC SPFFDPVTLG PKCFNNGKCT DRVGGYSCIC PPGFVGERCE
GDVNECLSNP CDARGTQNCV QRVNDYKCEC RPGYAGRRCD TVVDGCKGKP CRNGGTCAVA
SNTGRGFICK CPPGFVGATC ENDSRTCGNL HCLNGGTCIS IHKSSKCMCA PAFTGPECQY
PASSPCTPNP CYNRGTCEFF GDASPYYRCN CPANFNGLNC HILDFDFQGG IGQDIIPPKI
EEKCEIAVCA GYAGNKICDG KCNNHACGWD GGDCSLNFND PWKNCSQSLQ CWKYFNDGKC
DSQCNNAGCL YDGFDCQKYE GQCNPLYDQY CKDHFSDGHC DQGCNNFECE WDGLDCANNM
PEKLADGTLV VVVLITPENL KNNSFNFLRE LSRVLHTNVV FKKNAKGEYM IFPYYGNEEE
LKKHYIKRST EDWSDMSSAV INKVKSSLYS RAGRRQKREL DQMDIRGSIV YLEIDNRQCI
QSSSQCFQSA TDVAAFLGAL ASLGNLNIPY KIEAVKSETA EPAKNSQLYP MYVVVAALVL
LAFIGVGVLV SRKRRREHGQ LWFPEGFKVT ESSKKKRREP LGEDSVGLKP LKNASDGTLM
DDNQNEWGDE ETLDTKKFRF EEQAMLPDTD DQTDHRQWTQ QHLDAADLRI SSMAPTPPQG
EIDADCMDVN VRGPDGFTPL MIASCSGGGL ETGNSEEEDD APAVISDFIY QGASLHNQTD
RTGETALHLA ARYSRSDAAK RLLEASADAN IQDNMGRTPL HAAVSADAQG VFQILIRNRA
TDLDARMHDG TTPLILAARL AVEGMLDDLI NCHADVNAVD DLGKSALHWA AAVNNVEAAV
VLLKNGANKD MQNNKEETPL FLAAREGSYE TAKVLLDHFA NRDITDHMDR LPRDIAQERM
HHDIVRLLDE YNLVRSPPLH NGPLGAPTLS PPLCSPNSYI GNLKPAVQGK KARKPSTKGL
SCNGKDAKDL KARRKKSQDG KGCLLDNSSV LSPVDSLESP HGYLSDVASP PLMTSPFQQS
PSMPLNHLPG MPDAHMSINH LNMAGKQDMA MGNSSRMTFD SVPPRLSHLP VSSPSTAMSN
APMNFSVGGA AALNGQCEWL SRLQNGIVQN QYNPLRGNMQ PGAHQQTQNL QHGMMTTLHN
SLPTTSLSQM MSYQAMPNTR LASQPHLMQG QQLQQMQQQQ LQQPNQQQQQ PPPQHHNPSS
NTSGHIGQNF LGTELSQPDM QPVSGSXXPS CHKIPRCCPR LCRPPSPSP
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