ID A0A2I0M4L8_COLLI Unreviewed; 797 AA.
AC A0A2I0M4L8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Adhesion G protein-coupled receptor G4 {ECO:0000313|EMBL:PKK24629.1};
GN Name=ADGRG4 {ECO:0000313|EMBL:PKK24629.1};
GN ORFNames=A306_00009228 {ECO:0000313|EMBL:PKK24629.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK24629.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK24629.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK24629.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK24629.1}.
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DR EMBL; AKCR02000041; PKK24629.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0M4L8; -.
DR STRING; 8932.A0A2I0M4L8; -.
DR InParanoid; A0A2I0M4L8; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15997; 7tmB2_GPR112; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR001879; GPCR_2_extracellular_dom.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF277; ADHESION G-PROTEIN COUPLED RECEPTOR G4; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50227; G_PROTEIN_RECEP_F2_3; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:PKK24629.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 426..449
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 461..481
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 493..518
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 530..552
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 579..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 628..649
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 655..677
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 63..126
FT /note="G-protein coupled receptors family 2 profile 1"
FT /evidence="ECO:0000259|PROSITE:PS50227"
FT DOMAIN 424..679
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
SQ SEQUENCE 797 AA; 90661 MW; EF6DF3BBBA486434 CRC64;
MKAKQMSQSY VCKAIIKATS LEIQEVLSLK IKQLLNDIYE EGPLSLYVNP EDVAVKTIAL
MDCPESFSHT TYKGNYSWPL TSPATKVEVS CRKNPLQSAR RSCAINIELE QAFWKKPNFT
ECELLEELPN NILGLHDIMI IEENGQDVVR HILYLLPDAT LHMEELEIIA NKLADIVKLP
DMSMTLAETI LYILNYILLQ EIEDQNIRKI TNSILKATEE IGYKVTYTER NTSVVTTSLA
LLVMRPDPSM FEGLAFGVTS YHRGMDLKVD VQEKPFKKAL ASVFLPKSLK KFLGIEHSHP
DKHPKIQFKF FGTTSLFADN SLTKERLNTY VVSASIENAS VQNLNEPVTI TLQHRVQNMG
NAAVHCVFWD FQKNNGLGGW NTSGCEMEYT DMNYTICFCN HLTHFGVLLD LSRTEIDTTH
DRVLTLISYA GCGASSLFLG ITLVIYLALE KLRRDNPSKI LLNLCAALLM LNMVFLTNSW
LSSFNQPGLC VTVAALLHYF LLAAFTWMCL ESVHFYLALV KVFNVYVPKY ILKCCMAGWG
IPAIIITIVL IINKDFYGNG SQSESHPFSN FCWIQENRVF YISIVAYVFL IFLMNTAMFI
TILFQIHSVK SRTQKRSRFW KQGFLQDLKS AFSLMFLLGI TWGFVFFAWG TVRILFLYLF
SIFNTLQGFF IFVFHCLMKE EVAKQCQVHF CWGRFRLSNY SDWSGSGATA ESTPRHSNHK
SLSQASWSLN SNGTSSTSSG SDFLPRTSPD INFRIAEVHY NPSAVPPEDG ETKHSCSQRT
QLMETGLHYP QKARFFH
//
