ID A0A2I0M805_COLLI Unreviewed; 766 AA.
AC A0A2I0M805;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Cadherin-5 {ECO:0000256|ARBA:ARBA00021701};
DE AltName: Full=Vascular endothelial cadherin {ECO:0000256|ARBA:ARBA00030559};
GN Name=CDH5 {ECO:0000313|EMBL:PKK25812.1};
GN ORFNames=A306_00009346 {ECO:0000313|EMBL:PKK25812.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK25812.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK25812.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK25812.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Cadherins are calcium-dependent cell adhesion proteins.
CC {ECO:0000256|RuleBase:RU004357}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251,
CC ECO:0000256|RuleBase:RU003318}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004251, ECO:0000256|RuleBase:RU003318}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK25812.1}.
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DR EMBL; AKCR02000031; PKK25812.1; -; Genomic_DNA.
DR RefSeq; XP_005514507.1; XM_005514450.1.
DR RefSeq; XP_013226615.1; XM_013371161.1.
DR AlphaFoldDB; A0A2I0M805; -.
DR STRING; 8932.A0A2I0M805; -.
DR GeneID; 102097366; -.
DR KEGG; clv:102097366; -.
DR CTD; 1003; -.
DR InParanoid; A0A2I0M805; -.
DR OrthoDB; 3667774at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR CDD; cd11304; Cadherin_repeat; 5.
DR Gene3D; 2.60.40.60; Cadherins; 5.
DR Gene3D; 4.10.900.10; TCF3-CBD (Catenin binding domain); 1.
DR InterPro; IPR039808; Cadherin.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR020894; Cadherin_CS.
DR InterPro; IPR000233; Cadherin_Y-type_LIR.
DR InterPro; IPR027397; Catenin-bd_sf.
DR PANTHER; PTHR24027; CADHERIN-23; 1.
DR PANTHER; PTHR24027:SF89; CADHERIN-5; 1.
DR Pfam; PF01049; CADH_Y-type_LIR; 1.
DR Pfam; PF00028; Cadherin; 5.
DR PRINTS; PR00205; CADHERIN.
DR SMART; SM00112; CA; 5.
DR SUPFAM; SSF49313; Cadherin-like; 5.
DR PROSITE; PS00232; CADHERIN_1; 2.
DR PROSITE; PS50268; CADHERIN_2; 5.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837, ECO:0000256|PROSITE-
KW ProRule:PRU00043};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003318};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003318};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..766
FT /note="Cadherin-5"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014118124"
FT TRANSMEM 590..610
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..138
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 139..245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 246..360
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 361..468
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 468..576
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
SQ SEQUENCE 766 AA; 86011 MW; BA7B32D1C5314CD2 CRC64;
MNHLILLFSL FLAPATVDSE SQKTNDAGHK RQKRDWIWNQ MHIKEEIDTP LPHHVGKITS
SVRNNYAKYI IEGEYANTIF KVEETSGDVY AFERLDREKK AEYELTALII DRRNNQSLEP
PSKFIIKVYD INDNVPVFVQ KVFNGSVPEM SPVGTSVTKV TAVDADDPTV TGHATVTYQV
IKGDEYFTVD DSGVISTTRA DLDREHQSTY EIIVKAKDAP GSSGDSSTAT VIITLTDIND
NFPVFKHPSF HFKVPENISV GGEVGRVKVE DVDEPQHRNT KYSFVRGDYR DTFEIVANPF
TNEGIIRPKK PLDFEKVAEY RFDIEATDPT VDLRYFKSGG SRSISTVTIE VTDVDEPPVF
TKLPYEFKVR ENDPEIRTLG SVWAHDPDAA KRKIRFIRRR ASPNGDYVRV SDTGIIQLPK
PLDREFSSSY NITVAAQEIL EDGRLSDRES HAQVHVIVTD ENDNAPELVY PEEPRVCENA
APGKVIIRIS ATDKDETSPR GFFKYSLATE DSNFSLVENY DNTANITVKY GQFNRELAKI
HYLPVIISDN GDPELSSTNT LVISVCKCNE KGNFTFCEER AKQVGVSIQA LVAIFICIFT
IVIIALLILL RKRHKKDLSG LGRNVAEIHE QLVTYDEEGG GEMDTTSYDV SVLNSVRKNG
IKPEAAPSPY AQVQKPPGNM TSGAGEMEMM IEVKKDEADN DRDLLPYDTL HIYGYEGAES
IAESLSSLES GSSDSDIDYD FLNDWGPRFK MLAELYGSEP NEDFVY
//
