ID A0A2I0M8R9_COLLI Unreviewed; 187 AA.
AC A0A2I0M8R9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Adaptor-related protein complex 3, sigma 1 subunit {ECO:0000313|EMBL:PKK26077.1};
GN Name=AP3S1 {ECO:0000313|EMBL:PKK26077.1};
GN ORFNames=A306_00010547 {ECO:0000313|EMBL:PKK26077.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK26077.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK26077.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK26077.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Part of the AP-3 complex, an adaptor-related complex which is
CC not clathrin-associated. The complex is associated with the Golgi
CC region as well as more peripheral structures. It facilitates the
CC budding of vesicles from the Golgi membrane and may be directly
CC involved in trafficking to lysosomes. In concert with the BLOC-1
CC complex, AP-3 is required to target cargos into vesicles assembled at
CC cell bodies for delivery into neurites and nerve terminals.
CC {ECO:0000256|ARBA:ARBA00025605}.
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004180}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004180}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004180}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the adaptor complexes small subunit family.
CC {ECO:0000256|ARBA:ARBA00006972}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK26077.1}.
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DR EMBL; AKCR02000029; PKK26077.1; -; Genomic_DNA.
DR RefSeq; XP_013223701.1; XM_013368247.1.
DR AlphaFoldDB; A0A2I0M8R9; -.
DR STRING; 8932.A0A2I0M8R9; -.
DR GeneID; 102084033; -.
DR KEGG; clv:102084033; -.
DR CTD; 1176; -.
DR InParanoid; A0A2I0M8R9; -.
DR OrthoDB; 3059064at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0030123; C:AP-3 adaptor complex; IEA:InterPro.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006896; P:Golgi to vacuole transport; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR CDD; cd14834; AP3_sigma; 1.
DR Gene3D; 3.30.450.60; -; 1.
DR InterPro; IPR016635; AP_complex_ssu.
DR InterPro; IPR022775; AP_mu_sigma_su.
DR InterPro; IPR027155; APS3.
DR InterPro; IPR000804; Clathrin_sm-chain_CS.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR PANTHER; PTHR11753; ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY; 1.
DR PANTHER; PTHR11753:SF12; AP-3 COMPLEX SUBUNIT SIGMA-1; 1.
DR Pfam; PF01217; Clat_adaptor_s; 1.
DR SUPFAM; SSF64356; SNARE-like; 1.
DR PROSITE; PS00989; CLAT_ADAPTOR_S; 1.
PE 3: Inferred from homology;
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transport {ECO:0000256|ARBA:ARBA00022927}.
FT DOMAIN 17..141
FT /note="AP complex mu/sigma subunit"
FT /evidence="ECO:0000259|Pfam:PF01217"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 187 AA; 20807 MW; E61C2571961AB1B9 CRC64;
MESQWGSKKS KANSKSASED TQQQIIRETF HLVSKRDENV CNFLEGGLLI GGSDNKLIYR
HYATLYFVFC VDSSESELGI LDLIQVFVET LDKCFENVCE LDLIFHVDKV HNILAEMVMG
GMVLETNMNE IVTQIDAQNK LEKSEAGLAG APARAVSAVK NMNLPEIPRN INIGDISIKV
PNLPSFK
//
