ID A0A2I0M9L4_COLLI Unreviewed; 1090 AA.
AC A0A2I0M9L4;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Calcium channel, voltage-dependent, alpha 2/delta subunit 3 {ECO:0000313|EMBL:PKK26359.1};
GN Name=CACNA2D3 {ECO:0000313|EMBL:PKK26359.1};
GN ORFNames=A306_00009075 {ECO:0000313|EMBL:PKK26359.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK26359.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK26359.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK26359.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SIMILARITY: Belongs to the calcium channel subunit alpha-2/delta
CC family. {ECO:0000256|ARBA:ARBA00007060}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK26359.1}.
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DR EMBL; AKCR02000026; PKK26359.1; -; Genomic_DNA.
DR RefSeq; XP_005515398.1; XM_005515341.1.
DR AlphaFoldDB; A0A2I0M9L4; -.
DR STRING; 8932.A0A2I0M9L4; -.
DR GeneID; 102089718; -.
DR KEGG; clv:102089718; -.
DR CTD; 55799; -.
DR InParanoid; A0A2I0M9L4; -.
DR OrthoDB; 2971287at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0034702; C:monoatomic ion channel complex; IEA:UniProtKB-KW.
DR GO; GO:0005262; F:calcium channel activity; IEA:UniProtKB-KW.
DR CDD; cd12912; PDC2_MCP_like; 1.
DR CDD; cd01463; vWA_VGCC_like; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013680; VDCC_a2/dsu.
DR InterPro; IPR013608; VWA_N.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR10166; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATED; 1.
DR PANTHER; PTHR10166:SF25; VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3; 1.
DR Pfam; PF08473; VGCC_alpha2; 1.
DR Pfam; PF13768; VWA_3; 1.
DR Pfam; PF08399; VWA_N; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022673};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022673};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022882};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 255..437
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 1090 AA; 123793 MW; 3D7FB825EDF85D09 CRC64;
MPEHLNLFRA FGGVFFIFWT AFNTALVDVV GSEQQIPLSV VKLWASAFGG EIKSIAAKYS
GSQLLQKKYK EYEKDVAIEE IDGLQLVKKL AKNMEEMFHK KSEAVRRLVE AAEDAYLKHE
FDADLQYEYF NAVLINERDE EGNYLELGKE FILVPNDHFN NLPVNISLSD VQVPTNMYNK
DPAIVNGVYW SESLNKVFVD NFDRDPSLIW QYFGSAKGFF RQYPGIKWEP DENGVIAFDC
RNRKWYIQAA TSPKDVVILV DVSGSMKGLR LTIAKQTVSS ILDTLGDDDF FNIIAYNEEL
HYVEPCLNGT LVQADRANKE HFREHLDKLF AKGIGMLDIA LNEAFNMLNE FNHTGQGSIC
SQAIMLITDG AVDTYDTIFA KYNWPDRKVR IFTYLIGREA AFADNLKWMA CANKGFFTQI
STLADVQENV MEYLHVLSRP KVIDQEHDVV WTEAYIDSTL PQAQKLADDQ GLVLMTTVAM
PVFSKQNETR SKGILLGVVG TDVPVKELLK TIPKYKLGIH GYAFAITNNG YILTHPELRP
LYEEGKKRRK PNYSSVDLSE VEWEDRDDVL RNAMVNRKTG KFSMEVKKTV DKGKRVLVMT
NDYYYTDIKG TPFSLGVALS RGHGKYFFRG NVTVEEGLHD LEHPDVSLAD EWSYCNTDLH
PEHRQMSQLE AIRRYLTGKE PLLQCDKELI QEVLFDAVVS APIEAYWTSL ALNKSENSDK
GVEVAFLGTR TGLSRINLFV GPEQLTNQDF LTAEDKENIF NADHFPLWYR RAAEQIPGSF
VYSIPFSTET ANKSNVVTAS TAIQLLDDRK SPVVAAVGIQ MKLEFFQRKF WTASRQCASL
DGRCAISCDD EAINCYLIDN NGFILVSEDY GQTGYFFGEV EGAVMNKLLT MGSFKRITLY
DYQAMCRTNK ESSDSAHSLL DPYNAFFAAI KWIMTELVLF LVEFNLCSWW HSDLTAKAQR
LKQTLEPCDT EYPAFVSERT IKETTGNIAC DDCFKSFVIQ QIPSSNLFMV VVDNECFCDS
IPPITMAPIE IRYNESLKCE RLKSQKIRRR PESCHGFHPE ENARECGGVS GLSAKPPLVL
LPLLLTIFSR
//
