ID A0A2I0MEM9_COLLI Unreviewed; 485 AA.
AC A0A2I0MEM9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=GDNF family receptor alpha {ECO:0000256|PIRNR:PIRNR038071};
GN Name=GFRA1 {ECO:0000313|EMBL:PKK28122.1};
GN ORFNames=A306_00006519 {ECO:0000313|EMBL:PKK28122.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK28122.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK28122.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK28122.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004609};
CC Lipid-anchor, GPI-anchor {ECO:0000256|ARBA:ARBA00004609}. Membrane
CC {ECO:0000256|ARBA:ARBA00004589}; Lipid-anchor, GPI-anchor
CC {ECO:0000256|ARBA:ARBA00004589}.
CC -!- SIMILARITY: Belongs to the GDNFR family.
CC {ECO:0000256|ARBA:ARBA00005961, ECO:0000256|PIRNR:PIRNR038071}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK28122.1}.
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DR EMBL; AKCR02000017; PKK28122.1; -; Genomic_DNA.
DR RefSeq; XP_005508225.1; XM_005508168.1.
DR AlphaFoldDB; A0A2I0MEM9; -.
DR STRING; 8932.A0A2I0MEM9; -.
DR GeneID; 102097475; -.
DR KEGG; clv:102097475; -.
DR CTD; 2674; -.
DR InParanoid; A0A2I0MEM9; -.
DR OrthoDB; 3899332at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0098552; C:side of membrane; IEA:UniProtKB-KW.
DR GO; GO:0038023; F:signaling receptor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.220.110; GDNF binding domain; 1.
DR InterPro; IPR016017; GDNF/GAS1.
DR InterPro; IPR037193; GDNF_alpha.
DR InterPro; IPR003438; GDNF_rcpt.
DR InterPro; IPR003503; GDNF_rcpt_A1.
DR InterPro; IPR017372; Glial_neurotroph_fac_rcpt_a1/2.
DR PANTHER; PTHR10269:SF3; GDNF FAMILY RECEPTOR ALPHA-1; 1.
DR PANTHER; PTHR10269; GDNF RECEPTOR ALPHA; 1.
DR Pfam; PF02351; GDNF; 3.
DR PIRSF; PIRSF038071; GDNF_family_receptor_alpha; 1.
DR PRINTS; PR01317; GDNFRALPHA1.
DR PRINTS; PR01316; GDNFRECEPTOR.
DR SMART; SM00907; GDNF; 3.
DR SUPFAM; SSF110035; GDNF receptor-like; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475,
KW ECO:0000256|PIRNR:PIRNR038071};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW GPI-anchor {ECO:0000256|ARBA:ARBA00022622};
KW Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR038071};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|PIRNR:PIRNR038071};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 52..134
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 173..252
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
FT DOMAIN 262..356
FT /note="GDNF/GAS1"
FT /evidence="ECO:0000259|SMART:SM00907"
SQ SEQUENCE 485 AA; 53894 MW; BA932C1F8CE1A1CC CRC64;
MLIVFVVSYQ LVWGNHPDTK MFLAILYLAL PLVDVLLSTE VSGLPGGDRL DCVKASDQCL
KEQSCSTKYR TLRQCVAGKE SNFSRATGLE AKDECKSAME ALKQKSLYNC RCKRGMKKEK
NCLRIYWSMY QSLQGNDLLE DSPYEPVNSR LSDIFRLAPI VSVEPVLSKG NNCLDAAKAC
NLNDTCKRFR SAYITPCTSS TSNEICNKRK CHKALRLFFD KVPPKHSYGM LFCSCRDVAC
TERRRQTIVP VCSYEDREKP NCLNLQESCK KNYICRSRLA DFFTNCQPES RSVSSCLKEN
YADCLLAYSG LIGTVMTPNY IDSNSLSVAP WCDCSNSGND IDECLKFLNF FQDNICLKNA
IQAFGNGTDV NVWQPILPVQ TTTATTTTAS RLKNTGSEAT NNEIPTHNDS PACANLQAQK
KRKSNESVDT ELCLNENAIG KDNTAGVSTS HISSENSLAL PTSTPLTLMT LALSLYLFLS
SSVFL
//
