ID A0A2I0MF53_COLLI Unreviewed; 1174 AA.
AC A0A2I0MF53;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=BK channel {ECO:0000256|ARBA:ARBA00029579};
DE AltName: Full=Slowpoke homolog {ECO:0000256|ARBA:ARBA00033447};
GN Name=KCNMA1 {ECO:0000313|EMBL:PKK28323.1};
GN ORFNames=A306_00005129 {ECO:0000313|EMBL:PKK28323.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK28323.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK28323.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK28323.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. Calcium-activated
CC (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.
CC {ECO:0000256|ARBA:ARBA00008648}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK28323.1}.
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DR EMBL; AKCR02000016; PKK28323.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0MF53; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003929; K_chnl_BK_asu.
DR InterPro; IPR047871; K_chnl_Slo-like.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR048735; Slowpoke-like_C.
DR PANTHER; PTHR10027; CALCIUM-ACTIVATED POTASSIUM CHANNEL ALPHA CHAIN; 1.
DR PANTHER; PTHR10027:SF33; CALCIUM-ACTIVATED POTASSIUM CHANNEL SUBUNIT ALPHA-1; 1.
DR Pfam; PF03493; BK_channel_a; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF21014; Slowpoke_C; 1.
DR PRINTS; PR01449; BKCHANNELA.
DR PRINTS; PR00169; KCHANNEL.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000313|EMBL:PKK28323.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium channel {ECO:0000256|ARBA:ARBA00022826};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 20..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 115..133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 153..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 236..257
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 273..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 303..321
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 117..332
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 482..569
FT /note="Calcium-activated potassium channel BK alpha
FT subunit"
FT /evidence="ECO:0000259|Pfam:PF03493"
FT DOMAIN 941..1061
FT /note="Ca2+-activated K+ channel Slowpoke-like C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21014"
FT REGION 644..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1071..1139
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 651..669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1174 AA; 132010 MW; B083755C440DB2FE CRC64;
MDALIIPVTM EVPCDSRGQR MWWAFLASSM VTFFGGLFII LLWRTLKYLW TVCCHCGVKN
KEAQKINGGG DTQADGACKP TDEKEENVAA EVGWMTSVKD WAGVMISAQT LTGRVLVVLV
FALSIGALVI YFIDSSNPIE SCQNFYKDFT LQIDMAFNVF FLLYFGLRFI AANDKLWFWL
EVNSVVDFFT VPPVFVSVYL NRSWLGLRFL RALRLIQFSE ILQFLNILKT SNSIKLVNLC
SIFISTWLTA AGFIHLVENS GDPWENFQNN QPLTYWECVY LLMVTMSTVG YGDVYAKTTL
GRLFMVFFIL GGLAMFASYV PEIIELIGNR KKYGGSYSAV SGRKHIVVCG HITLESVSNF
LKDFLHKDRD DVNVEIVFLH NISPNLELEA LFKRHFTQVE FYQGSVLNPH DLARVKIESA
DACLILANKY CADPDAEDAS NIMRVISIKN YHPKIRIITQ MLQYHNKAHL LNIPSWNWKE
GDDAICLAEL KLGFIAQSCL APGLSTMLAN LFSMRSFIKI EEDTWQKYYL EGVANEMYTE
YLSSAFVGLS FPAVCELVFA KLKLLMIAIE YKSEKRESSS LSSILINPGN HVKIQEGTLG
FFIASDAKEV KRAFFYCKAC HDDITDPKRI KKCGCKRLFP VEDEQPSTLS PKKKQRNGGM
RNSPNSSPKL MRHDPLLIPG NEQIDNMDAN VKKYDSTGMF HWCPAKDIEK VILTRSEAAM
TVLSGHVVVC IFGDVKSALI GLRNLVMPLR ASNFHYHELK HIVFVGSLEY LRREWETLHN
FPKVSILPGT PLSRADLRAV NINLCDMCVI LSANQNNIDD ASLQDKECIL ASLNIKSMQF
DDSIGVLQAN SQGFTPPGMD RSSPDNSPVH GLLRQPSITT GANIPIITEL VNDSNVQFLD
QDDDDDPDTE LYLTQPFACG TAFAVSVLDS LMSATYFNDN ILTLIRTLVT GGATPELEAL
IAEENALRGG YSTPQTLANR DRCRVAQLAL YDGPFADLGD GGCYGDLFCK ALKTYNMLCF
GIYRLRDAHL STPSQCTKRY VITNPPYEFE LVPTDLIFCL MQFDHNAGQS RASLSHSSHS
SYSSSKKSSS VHSIPSTANR PNRTKTRDSR EKQNATRMNR MGQAEKKWFT DEPDNAYPRN
IQIKPMSTHM ANQINQYKST SSLIPPIREV EDEC
//
