ID A0A2I0MH52_COLLI Unreviewed; 234 AA.
AC A0A2I0MH52;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 12.
DE SubName: Full=Sec61 translocon alpha 2 subunit {ECO:0000313|EMBL:PKK29011.1};
GN Name=SEC61A2 {ECO:0000313|EMBL:PKK29011.1};
GN ORFNames=A306_00007071 {ECO:0000313|EMBL:PKK29011.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29011.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29011.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29011.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}.
CC -!- SIMILARITY: Belongs to the SecY/SEC61-alpha family.
CC {ECO:0000256|RuleBase:RU004349}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29011.1}.
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DR EMBL; AKCR02000012; PKK29011.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0MH52; -.
DR STRING; 8932.A0A2I0MH52; -.
DR InParanoid; A0A2I0MH52; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015031; P:protein transport; IEA:InterPro.
DR Gene3D; 1.10.3370.10; SecY subunit domain; 1.
DR InterPro; IPR002208; SecY/SEC61-alpha.
DR InterPro; IPR023201; SecY_dom_sf.
DR PANTHER; PTHR10906:SF10; PROTEIN TRANSPORT PROTEIN SEC61 SUBUNIT ALPHA ISOFORM 2; 1.
DR PANTHER; PTHR10906; SECY/SEC61-ALPHA FAMILY MEMBER; 1.
DR Pfam; PF00344; SecY; 1.
DR SUPFAM; SSF103491; Preprotein translocase SecY subunit; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 42..62
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 119..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 174..192
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 199..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 234 AA; 25581 MW; 1189EDFF3EC00782 CRC64;
MNLIATVFVF AVVIYFQGFR VDLPIKSARY RGQYSSYPIK LFYTSNIPII LQSALVSNLY
VISQMLSVRF SGNFLVNLLG QWADVSGGGP ARSYPVGGLC YYLSPPESMG AIFDDPVHVI
VYIIFMLGSC AFFSKTWIEV SGSSAKDVAK QLKEQQMVMR GHRDTSMVHE LNRYIPTAAA
FGGLCIGALS VLADFLGAIG SGTGILLAVT IIYQYFEIFV KEQAEVGGVG ALFF
//
