ID A0A2I0MHX8_COLLI Unreviewed; 672 AA.
AC A0A2I0MHX8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE RecName: Full=Potassium voltage-gated channel subfamily KQT member 1 {ECO:0000256|ARBA:ARBA00019342};
DE AltName: Full=KQT-like 1 {ECO:0000256|ARBA:ARBA00029687};
DE AltName: Full=Voltage-gated potassium channel subunit Kv7.1 {ECO:0000256|ARBA:ARBA00030121};
GN Name=KCNQ1 {ECO:0000313|EMBL:PKK29282.1};
GN ORFNames=A306_00004630 {ECO:0000313|EMBL:PKK29282.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29282.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29282.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29282.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Basolateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004187}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651}. Cytoplasmic vesicle membrane
CC {ECO:0000256|ARBA:ARBA00004156}. Endoplasmic reticulum
CC {ECO:0000256|ARBA:ARBA00004240}. Lateral cell membrane
CC {ECO:0000256|ARBA:ARBA00004124}. Membrane raft
CC {ECO:0000256|ARBA:ARBA00004285}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel family. KQT (TC 1.A.1.15)
CC subfamily. Kv7.1/KCNQ1 sub-subfamily. {ECO:0000256|ARBA:ARBA00009499}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29282.1}.
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DR EMBL; AKCR02000011; PKK29282.1; -; Genomic_DNA.
DR RefSeq; XP_005499407.1; XM_005499350.1.
DR AlphaFoldDB; A0A2I0MHX8; -.
DR STRING; 8932.A0A2I0MHX8; -.
DR InParanoid; A0A2I0MHX8; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016323; C:basolateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR GO; GO:0016328; C:lateral plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0045121; C:membrane raft; IEA:UniProtKB-SubCell.
DR GO; GO:0008076; C:voltage-gated potassium channel complex; IEA:InterPro.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 6.10.140.1910; -; 2.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR003937; K_chnl_volt-dep_KCNQ.
DR InterPro; IPR013821; K_chnl_volt-dep_KCNQ_C.
DR InterPro; IPR005827; K_chnl_volt-dep_KCQN1.
DR PANTHER; PTHR47735:SF6; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 1; 1.
DR PANTHER; PTHR47735; POTASSIUM VOLTAGE-GATED CHANNEL SUBFAMILY KQT MEMBER 4; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF03520; KCNQ_channel; 1.
DR PRINTS; PR00169; KCHANNEL.
DR PRINTS; PR01460; KCNQ1CHANNEL.
DR PRINTS; PR01459; KCNQCHANNEL.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|ARBA:ARBA00023329};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Ion channel {ECO:0000313|EMBL:PKK29282.1};
KW Ion transport {ECO:0000313|EMBL:PKK29282.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000313|EMBL:PKK29282.1}.
FT TRANSMEM 100..119
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 125..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 177..200
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 239..261
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 304..330
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..335
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 513..624
FT /note="Potassium channel voltage dependent KCNQ C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03520"
FT REGION 628..672
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..661
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 672 AA; 76156 MW; 7788F64351BAC0DD CRC64;
MTNRFTPQLI TPGTAWSVGQ AVILVIYIKK NLLEDPNSSR ALLLPGAKIL QKETEQQALK
ALVVLNLSIA NGGFWQRTLH VDSHVPCVVR YQREQFGNQW TIGLFCFLIV LICLIFSVLS
TIEQYAALAT GTLFWMEIVL VVFFGTEYVV RLWSAGCRSK YVGVWGRLRF ARKPISIIDL
IVVVASMIVL CVGSKGQVFA TSAIRGIRFL QILRMLHVDR QGGTWRLLGS VVFIHRQELI
TTLYIGFLGL IFSSYFVYLA EKDAVNDSGE TEFGSYADAL WWGVVTVTTI GYGDKVPQTW
IGKTIASCFS VFAISFFALP AGILGSGFAL KVQQKQRQKH FNRQIPAAAS LIQTAWRCYA
AENPDSSTWK IYIRRPARNY HLLSPSPKPK KSVMVKKKKF KLDKDNGPAS PDRMLTVPHI
TYDHVMEDRK PDFSFEAYEN SGQTGMLKLL DCQRSWPSFS TDQQSSSVPS SPVKKSPMFL
DVNTGPFIRT SSFADELDLE GETLLTPITH ISQLREHHRA AIKVIRRMQY FVAKKKFQQA
RKPYDVRDVI EQYSQGHLNL MVRIKELQRR LDQSIGKPSL FISVSEKSKD RGNNTIGARL
NRVEDKVTQM DQKLNLITDM LHHLISRQQG DQGNNRSPQR GHNVNSDLFL PNNTLPTYEQ
LTVPRRNEDD IS
//
