ID A0A2I0MHZ5_COLLI Unreviewed; 3478 AA.
AC A0A2I0MHZ5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Otogelin {ECO:0000313|EMBL:PKK29297.1};
GN Name=OTOG {ECO:0000313|EMBL:PKK29297.1};
GN ORFNames=A306_00004653 {ECO:0000313|EMBL:PKK29297.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29297.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29297.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29297.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29297.1}.
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DR EMBL; AKCR02000011; PKK29297.1; -; Genomic_DNA.
DR RefSeq; XP_013225114.1; XM_013369660.1.
DR STRING; 8932.A0A2I0MHZ5; -.
DR InParanoid; A0A2I0MHZ5; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0046556; F:alpha-L-arabinofuranosidase activity; IEA:InterPro.
DR GO; GO:0046373; P:L-arabinose metabolic process; IEA:InterPro.
DR CDD; cd19941; TIL; 4.
DR Gene3D; 2.80.10.50; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 4.
DR InterPro; IPR007934; AbfB_ABD.
DR InterPro; IPR036195; AbfB_ABD_sf.
DR InterPro; IPR006207; Cys_knot_C.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036084; Ser_inhib-like_sf.
DR InterPro; IPR002919; TIL_dom.
DR InterPro; IPR014853; VWF/SSPO/ZAN-like_Cys-rich_dom.
DR InterPro; IPR001007; VWF_dom.
DR InterPro; IPR001846; VWF_type-D.
DR PANTHER; PTHR11339; EXTRACELLULAR MATRIX GLYCOPROTEIN RELATED; 1.
DR PANTHER; PTHR11339:SF228; OTOGELIN; 1.
DR Pfam; PF05270; AbfB; 1.
DR Pfam; PF08742; C8; 4.
DR Pfam; PF01826; TIL; 1.
DR Pfam; PF00094; VWD; 4.
DR SMART; SM00832; C8; 4.
DR SMART; SM00041; CT; 1.
DR SMART; SM00215; VWC_out; 2.
DR SMART; SM00216; VWD; 4.
DR SUPFAM; SSF110221; AbfB domain; 1.
DR SUPFAM; SSF57603; FnI-like domain; 1.
DR SUPFAM; SSF57567; Serine protease inhibitors; 4.
DR PROSITE; PS01225; CTCK_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51233; VWFD; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00039}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 69..106
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 117..290
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 478..654
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 941..1110
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 2665..2841
FT /note="VWFD"
FT /evidence="ECO:0000259|PROSITE:PS51233"
FT DOMAIN 3393..3478
FT /note="CTCK"
FT /evidence="ECO:0000259|PROSITE:PS01225"
FT REGION 1504..1532
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1566..1586
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1957..2015
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 3407..3456
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00039"
SQ SEQUENCE 3478 AA; 381019 MW; B90AC91F3B14A33E CRC64;
MEWNGMEDRE DMAVPAITNL SPLPSSPFSV GCPGAAPHWW GFTIPQESGV AVSNASSTTI
SLSQKRRLDS MKCGSSNSFT CFNGGECVYR ELCNCSRFNA SGPRCQTVYN TGAERDHICR
TWGQYNFETF DGLYYYFPGK STYALVRHTE LDEQSFSIQV NNDPECHSSP YSCRRSISLF
FSGDEQIKMS SEVTYKGFGV QLPYIIGNLH IQKLAGYFLV RHQYAFTLAW DGTSAMYIKM
TPEYLGKTQG LCGNNNAILQ DDLETSYGKL TDDVTEFVES WQENPPQGTP SWDKSLLNEP
PCLTQSHESL QRAYTLCNIL LQPPFKQCHE YVSPLPFMAS CTNDLCMSAV DNATWCRALT
EYARACAQAG KPLHGWRMRF QQCVIACVEP LTYNECINCC PVSCHQQSQC IGSELPCIDG
CYCPDGLIYE NGLCVKPMDC PCDYHGSFLE MGSVVYEECN NCTCIGGKWI CTNLTCPAEC
SVSGDIHFKT FDGRKYTFQA TCQYILAKSR TSGAFTISLQ NAPCGQNQDG SCIQSVSLIL
KQDPKRQVTL THSGDVLVYD QYKINLPYAD ELFEIRKLSS LFLQVKTHIG LQILYDREGL
RLYLQADGRW KDDTVGLCGT FNGNTEDDFL SPVGVTESTP ELFGNTWRTS SACVLVHDSS
QMDPCDIHLQ AASYAAEACS ILTKELFAPC YPYLSPVPYF EQCRRDTCKC GQVCFCSALA
HYAHRCRRFG VVIDFRGGVP DCALSCEDTK EYSTCVSMCG RTCQALSVPE TCSSDCVEGC
ACPSGMYLNS KTDRCVQRNE CPCYFQGIDY PPGENIMTSL GKCHCRDGVM NCDNNIIVHG
CPAGQISINC SNPQVDPELS RERTCENQLL NLTFSAHLPC VSGCVCPPGL VKHGDVCLDA
DECPCLWKGK EYFPGDKVIS SCHTCVCQRG SFQCTFHPCP SMCTAYGDRH YRTFDGLTFD
FVGTCKVYLV KGTSSTTFSV IIENINCFNT GVICRKNIFI NVGKSFLIFD DETGNPSLSS
YVDDLKKIQL WKAGFFTVVH FPDEHVTILW DQRTTVHVQM GHQWQGKLTG LCGNFDLKTV
NELRTPDNFE LTNSQEFGNS WTAVECVDSS DIRNPCSLNP LREPFAKKEC GILLSEAFEA
CHPVIDVTWF YSNCLTDTCG CNQGDDCECF CTSVSAYAHQ CCQHGVAVDW RSPRVCPYDC
EYFNKALGKG PYKLVSYLDE EFVMAVRLVD GVVFPVREED IVPGHAASFM LTSGLYKPKA
HDSNLISFEA ADRPNYFLRL ASNNTLVLSK WEKREVFHNR STFIIHKNTW LSGYSSFESF
AKPGYFIHIS SSSVDLLKYH HSEEYRLSIL FKLVDVKFKF LSRSACEWHY DACTSPCFKT
CRDPLGKTCQ AVPKVEGCVP ACPLNMLLDE ITQRCVYFED CIEPADDSLP LPPSIHTPTV
SQITSSTSLA VSSEAVSSFP VPEVKDMETT LASKLPFTAT PGKTEFSALT SITTLPTITL
SSNISSQSTE MTSGRSTTAM SGTTQSNVSL SSPADISPLF PSTVSSETST KIQLISSGST
KLLRATEPQT VTATHPVTTS TESESRPFST FIYTGTPLGT TEFPVKTKIM EIPEITTRTL
PMKEAQAKPG GLTSFTPSSF ESVTEKTTVY LPQFSTSPRQ GMPSYMPPVN LTGTSEGSKI
SVEQSFTTVA NVTLASFSPV VTTLLKPVSS ATTEAAVLTK QSMKTTFSPT ATPLISLGKA
ITEPPVEMVQ HRTGTAEVTS TTTLAPKTTL QSQERLSETT LLSFTAHKKE TPKTTSHVEH
TSSSYFPPYS VHPRSTTEKS VTLFTKRPSV SVLTPASPAS GELKKTFKTV STTGYPSYIV
LNTTEFLTTL YTKYPVVAET TKVTPLSVEV TSKMTSPFEL STKSTLFSGK MSTEIKSTLA
SSMVKTSSSG YLGTVTTSAM QTSISSKETT TVPFVATERE SAQRTSITGS PLSLSSTTET
TLLTTQPDKT QAERSSSIST RKPSAFTPSP SSSLISSDIS LPSLPSYGKE ASLTALSPVH
TSHEMISLFP ITKSSYTFST SQYIADKLVS LSSLTQMIPE VTTAPKYPVE TKIVSTALKS
TVQSITDTVK LTAVTAQPSF LPSSVGPFSR QTSSADKLSV QITKSMAIPR FSSQTTVKLG
HQTPAPLLTS QSSTPIYQYP AETLRKSTGQ PQHVFSTAES MVKLTSSLPE GIHSSILHTS
VGPTQVILPT AKELHLTDSV TQPYVSRTSS VLQSTIPTRT VADLISGTRI HPSSTEVLAA
SSALGTVKKE AFPSFSTQKA GTGPKFTWQS SFTESLYSSQ TLETTTASPE TKSISSSVLL
PETTEIPVVM GSGPFTSAGR TGTEKTVVLP KQVTLSTTAY SSTFVASTTL SAVAHSSAAA
SASSMISSTE KNVSILSATS EKAEAITESI TSSVKPTYFS VTSEAKGAMS LDTVKSEEPE
LAEVQAVHAQ GAPVTSRTPQ TFYSPYFTNT TAVLSNLSVS VLSTVRSSSE PKPFSSVAAS
LVSTTQTSKH EIPSEVQTRS MTSLLMVPDH SNDTAAPSVS SFAYLSSKPL YGLTAAFSDG
LATAETMSGV TASALMLPRE TASLQTCTPI TENECIKHIC LNGQLIQVNK SQNCPYNATQ
HSCGVLGFAA QVNGDKCCPK WECACRCTIF SDLSIVTYDG NHLALFKEAS YIVSQTRDET
ISIHVLDCKM SNSNSTSLCL AMLNLTYVSN QIIINRLSRK ITVNSRFAWP TVRKYGYKIE
DSGFKYAVET PTKIRIQWFH NTGVMIIEFN STREPRALGL CGFCDRSLEN DLMLPNRTVL
SKSDPPLAFI DSWQVPGTLK YVGEDRHQET NCSTMDCSEC LRLVLNQTFS SCHPYVPPEL
FCNMWAQDTE YIQNPCISLA AYVAMCNKFN ICIEWRSSDY CPFPCSENFS YRACIAACEV
ADSCQNNEVA SLDSDSCSVL TEGCVCAAGT ILHRAHTAVC IPEEKCACTD SSGAPHAVGE
IWKTSLSGCC MQKCVDSETI IPVEHNCSDI HNLDCQRFAE VALLVPDDHT CCPQKICICN
QSLCEPLIPK CNDLEKLVTY YSEESCCPSY VCECDPAKCE PVEQMPSCQD DQTLVASRVE
STCCISYICA CGACSDRIPK CQEGEVLIVD GNTTERCCPT YQCICEIHRC PEFKCMLGMS
LVEVWSPENC CPFRTCECAC ETIPKPQCKL GQKLQIDEQF QNSTENICNC VKYICVRDKV
CLSNERGVLR PGQTIVEHSA DGICHVSYCT NVIDPSTKYY RINTSSIDCA VKCKANQVYQ
PPKDLTTCCG SCKNLSCLHT FSNGTVSNFK PGTVWISNCI RYECTNTAIG PVLVSSSVGC
PPFNETECVK VGGYVVPFLE GCCKTCKEDG KFCKKVTVRM TIRKNDCRSN TPVNIVSCDG
KCPSASIYNY NINTYARFCK CCRELGLQRR TVQLYCASNS TWVSYSVQEP TDCSCQWS
//
