ID A0A2I0MI90_COLLI Unreviewed; 860 AA.
AC A0A2I0MI90;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Carnitine palmitoyltransferase 1A (Liver), transcript variant X1 {ECO:0000313|EMBL:PKK29380.1};
DE SubName: Full=Carnitine palmitoyltransferase 1A (Liver), transcript variant X2 {ECO:0000313|EMBL:PKK29378.1};
GN Name=CPT1A {ECO:0000313|EMBL:PKK29378.1};
GN ORFNames=A306_00004577 {ECO:0000313|EMBL:PKK29378.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29378.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29378.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29378.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
RN [2] {ECO:0000313|EMBL:PKK29378.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29378.1};
RA Holt C., Campbell M., Edelman N., Keays D., Kapusta A., Domyan E., Suh A.,
RA Carleton J., Warren W., Yandell M., Gilbert M.T., Shapiro M.D.;
RT "Improved genome assembly and annotation for the rock pigeon (Columba
RT livia).";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29378.1}.
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DR EMBL; AKCR02000011; PKK29378.1; -; Genomic_DNA.
DR EMBL; AKCR02000011; PKK29380.1; -; Genomic_DNA.
DR RefSeq; XP_013224675.1; XM_013369221.1.
DR RefSeq; XP_013224676.1; XM_013369222.1.
DR AlphaFoldDB; A0A2I0MI90; -.
DR STRING; 8932.A0A2I0MI90; -.
DR GeneID; 102089943; -.
DR CTD; 1374; -.
DR InParanoid; A0A2I0MI90; -.
DR OrthoDB; 1429709at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004095; F:carnitine O-palmitoyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR Gene3D; 6.10.250.1760; -; 1.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR InterPro; IPR032476; CPT_N.
DR InterPro; IPR005172; CRC.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR PANTHER; PTHR22589:SF74; CARNITINE O-PALMITOYLTRANSFERASE 1, LIVER ISOFORM; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR Pfam; PF16484; CPT_N; 1.
DR Pfam; PF03638; TCR; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00439; ACYLTRANSF_C_1; 1.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
DR PROSITE; PS51634; CRC; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PKK29378.1};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 761..860
FT /note="CRC"
FT /evidence="ECO:0000259|PROSITE:PS51634"
FT ACT_SITE 473
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 860 AA; 97965 MW; C508A5DF4FC6853E CRC64;
MAEAHQAVAF QFTVTPDGID LRMSHEALKQ IYLSGVHSWK KKFIRFKNGI ITGVYPASPS
SWLIVVVGVM STMYAKIDPS LGIIAKINRT LDTTGCMSNQ TQNIVSGILF GTGLWVALIV
TMRYSLKMLL SYHGWMFAEH GKLSAGTRVW MALVKLFSGR KPMLYSFQTS LPRLPVPAVK
DTVNRYLESV RPLMDDGEFR RMEGLAKDFA FNLGPRLQWY LKLKSWWATN YVSDWWEEYV
YLRGRGPIMV NSNYFAMDFL YLSPTTLQAA RAGNVIHAIL LYRKKLDRQE IKPILLMGST
VPLCSAQWER MFNTSRIPGE ESDTLQHVKD SKHIVVYHKG RYFKVWLYHD GRLLKPREIE
QQMQRILDDD SEPQTGEKKL AALTAGDRVP WARARQAYFS HGKNKQSLDA VEKAAFFVTL
DDIEQGYRKE DPVRSLDAYA KSLIHGRCYD RWFDKTFTLI VFKNGRMGLN AEHSWADAPI
VGHLWENVMA TEYLELGYSE DGHCKGDTNQ NIPIPTKLQW EIPEECQEVI ERSLSTAIAL
ADDVDFHSFF FDAFGKGLIK KAKTSPDGFV QLALQLAHYR DMGKFSLTYE ASMTRLFREG
RTETVRSCTV ESCNFVRTME DPTESNENKL KLFQLAAAKH QHLYRLAMTG AGIDRHLFCL
YVVSKYLAVD SPFLKEVLSE PWRLSTSQTP QQHIDLKKNP EMLSCGGGFG PVADDGYGVS
YIILDEDSIH FHVSSKISCS DTFENGPLQP VDSTATFHLE SHMHGQVKMT SEGYCDCFAN
GDFCKNCNCD NCCNNQLHET ERLTAIKACL ERNPEAFLPK IGKRKLGEIK HHHNKGCNCK
RSGCLENYCE CFEVIHKGEE
//
