ID A0A2I0MIT2_COLLI Unreviewed; 1240 AA.
AC A0A2I0MIT2;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN Name=SCN1A {ECO:0000313|EMBL:PKK29583.1};
GN ORFNames=A306_00003910 {ECO:0000313|EMBL:PKK29583.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29583.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29583.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29583.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability of
CC excitable membranes. Assuming opened or closed conformations in
CC response to the voltage difference across the membrane, the protein
CC forms a sodium-selective channel through which Na(+) ions may pass in
CC accordance with their electrochemical gradient.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU361132}.
CC Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29583.1}.
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DR EMBL; AKCR02000010; PKK29583.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0MIT2; -.
DR STRING; 8932.A0A2I0MIT2; -.
DR InParanoid; A0A2I0MIT2; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR CDD; cd13433; Na_channel_gate; 1.
DR Gene3D; 1.10.287.70; -; 3.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 1.20.5.1190; iswi atpase; 1.
DR Gene3D; 1.20.120.350; Voltage-gated potassium channels. Chain C; 3.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR008051; Na_channel_a1su.
DR InterPro; IPR001696; Na_channel_asu.
DR InterPro; IPR044564; Na_chnl_inactivation_gate.
DR InterPro; IPR010526; Na_trans_assoc_dom.
DR InterPro; IPR043203; VGCC_Ca_Na.
DR InterPro; IPR027359; Volt_channel_dom_sf.
DR PANTHER; PTHR10037:SF280; SODIUM CHANNEL PROTEIN TYPE 1 SUBUNIT ALPHA; 1.
DR PANTHER; PTHR10037; VOLTAGE-GATED CATION CHANNEL CALCIUM AND SODIUM; 1.
DR Pfam; PF00520; Ion_trans; 3.
DR Pfam; PF06512; Na_trans_assoc; 1.
DR PRINTS; PR00170; NACHANNEL.
DR PRINTS; PR01664; NACHANNEL1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 3.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Ion channel {ECO:0000256|RuleBase:RU361132, ECO:0000313|EMBL:PKK29583.1};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU361132};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361132};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Sodium {ECO:0000256|ARBA:ARBA00023053, ECO:0000256|RuleBase:RU361132};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461,
KW ECO:0000256|RuleBase:RU361132};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361132};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361132};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361132};
KW Voltage-gated channel {ECO:0000256|ARBA:ARBA00022882,
KW ECO:0000256|RuleBase:RU361132}.
FT TRANSMEM 6..22
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 34..52
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 114..142
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 201..227
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 453..471
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 492..511
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 567..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 694..717
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 776..794
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 806..824
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 836..856
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 893..921
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT TRANSMEM 997..1020
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361132"
FT DOMAIN 3..232
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 241..447
FT /note="Sodium ion transport-associated"
FT /evidence="ECO:0000259|Pfam:PF06512"
FT DOMAIN 451..726
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT DOMAIN 775..1030
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
FT REGION 364..410
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1216..1240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1223..1240
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1240 AA; 141391 MW; 8C5AB323AAF00656 CRC64;
MDPFVDLAIT ICIVLNTLFM AMEHYPMTDE FNNVLSVGNL VFTGIFTAEM FLKVIAMDPY
YYFQEGWNIF DGFIVTLSLV ELGLADVEGL SVLRSFRLLR VFKLAKSWPT LNMLIKIIGN
SVGALGNLTL VLAIIVFIFA VVGMQLFGKN YKECVCKIAS DCVLPRWHMQ DFFHSFLIVF
RVLCGEWIET MWDCMEVAGQ AMCLTVFMMV MVIGNLVVLN LFLALLLSSF SADNLAVTDD
DNEMNNLQIA VARMQKGIDY VKRKAREFIQ KAFVKKQKAL DEIKPLEDLN NKNSCISNHT
TVELSKDHDY IRDANGTTSG IGTGSSVEKY IIDESDYMSF INNPSLTVTV PIALGESDFE
NLNTEEFSSE SDLEESKEKL NTSSSSEGST VDIGLPAEEQ PEAEPEEAQE PEACFTEGCV
RRFKCCQVSI EEGRGKQWWN LRKTCFRIVE HNWFETFIVF MILLSSGALA FEDIYIEQRK
TIKTMLEYAD KVFTYIFILE MLLKWVAYGY QTYFTNAWCW LDFLIVDVSL VSLTANALGY
SELGAIKSLR TLRALRPLRA LSRFEGMRVV VNALLGAIPS IMNVLLVCLI FWLIFSIMGV
NLFAGKFYYC VNTTTDERFE VDQINNFSQC EELIKNNQSA RWKNVKVNFD NVGFGYLSLL
QVATFKGWMD IMYAAIDSRD ILQQPKYEDN LYMYLYFVIF IIFGSFFTLN LFIGVIIDNF
NQQKKKFGGQ DIFMTEEQKK YYNAMKKLGS KKPQKPIPRP GNKFQGMVFD FVTQQVFDIS
IMILICLNMV TMMVETDDQS KEMENILYWI NLVFIVLFTG ECVLKLISLR HYYFTIGWNI
FDFVVVILSI VGMFLAEMIE KYFVSPTLFR VIRLARIGRI LRLIKGAKGI RTLLFALMMS
LPALFNIGLL LFLVMFIYAI FGMSNFAYVK REAGIDDMFN FETFGNSMIC LFQITTSAGW
DGLLAPILNS GEPDCDPHKD HPGSSVKGDC GNPSVGIFFF VSYIIISFLV VVNMYIAVIL
ENFGVATEES AEPLSEDDFE MFYEVWEKFD PDATQFMEFE KLSDFAAALE PPLHLPKPNK
VQLIAMDLPM VSGDRIHCLD ILFAFTKRVL GESGEMDALR IQMEDRFMAS NPSKASYEPI
TTTLKRKQEE VSAVIIQRAY RRHLLKRTVK QASFIYNKNK TEGGAGLGVK DEILLDKLNE
NSFTEKTDVT ASTALCPPSY DRVTRPVKEK HEKEGKDVQK
//
