ID A0A2I0MJ88_COLLI Unreviewed; 353 AA.
AC A0A2I0MJ88;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=RNA binding protein fox-1 homolog {ECO:0000256|PIRNR:PIRNR037932};
GN ORFNames=A306_00004974 {ECO:0000313|EMBL:PKK29740.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29740.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29740.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29740.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: RNA-binding protein that regulates alternative splicing
CC events. {ECO:0000256|PIRNR:PIRNR037932}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR037932}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29740.1}.
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DR EMBL; AKCR02000009; PKK29740.1; -; Genomic_DNA.
DR RefSeq; XP_005511320.1; XM_005511263.2.
DR AlphaFoldDB; A0A2I0MJ88; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IEA:InterPro.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd12407; RRM_FOX1_like; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR025670; Fox-1_C_dom.
DR InterPro; IPR034237; FOX1_RRM.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR017325; RBFOX1-3.
DR InterPro; IPR047131; RBFOX1-like.
DR InterPro; IPR000504; RRM_dom.
DR PANTHER; PTHR15597; ATAXIN 2-BINDING PROTEIN 1-RELATED; 1.
DR PANTHER; PTHR15597:SF31; RNA BINDING PROTEIN FOX-1 HOMOLOG 2; 1.
DR Pfam; PF12414; Fox-1_C; 1.
DR Pfam; PF00076; RRM_1; 1.
DR PIRSF; PIRSF037932; Ataxin_2_bd_A2BP; 1.
DR SMART; SM00360; RRM; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR PROSITE; PS50102; RRM; 1.
PE 4: Predicted;
KW mRNA processing {ECO:0000256|PIRNR:PIRNR037932};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187,
KW ECO:0000256|PIRNR:PIRNR037932}; Nucleus {ECO:0000256|PIRNR:PIRNR037932};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW RNA-binding {ECO:0000256|PIRNR:PIRNR037932, ECO:0000256|PIRSR:PIRSR037932-
KW 1}.
FT DOMAIN 118..194
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 35..124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 119
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 127
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 128
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 152
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 157
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 161
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 185
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
FT SITE 195
FT /note="Interaction with RNA"
FT /evidence="ECO:0000256|PIRSR:PIRSR037932-1"
SQ SEQUENCE 353 AA; 37767 MW; 3E0896420411F14B CRC64;
MYGVYCMDYQ YPVVQGNQEP AATPDAMVQP FTTIPFPPPP QNGIPTEYGV PHTQDYAGQT
SEHNLTLYGS TQPHGEQSTN TASTQNGSLA QTEGGAQTDG QQSQTQNSEN TESKSTPKRL
HVSNIPFRFR DPDLRQMFGQ FGKILDVEII FNERGSKGFG FVTFENSADA DRAREKLHGT
VVEGRKIEVN NATARVMTNK KMVTPYANGW KLSPVVGAVY GPELYAVPGF PYPTAATTAA
AFRGAHLRGR GRTVYGAVRA VPPTAIPAYP GIVLQEPIIS AKIPQGGYAA YRYAQPATAT
AATAAAAAAA AYSDGYGRVY TADPYHALAP AASYGVGAVA SLYRGGYSRF APY
//
