ID A0A2I0MJF9_COLLI Unreviewed; 962 AA.
AC A0A2I0MJF9;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE RecName: Full=Exportin-T {ECO:0000256|ARBA:ARBA00018928, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=Exportin(tRNA) {ECO:0000256|ARBA:ARBA00029784, ECO:0000256|RuleBase:RU366037};
DE AltName: Full=tRNA exportin {ECO:0000256|ARBA:ARBA00032199, ECO:0000256|RuleBase:RU366037};
GN Name=XPOT {ECO:0000313|EMBL:PKK29807.1};
GN ORFNames=A306_00004997 {ECO:0000313|EMBL:PKK29807.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29807.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK29807.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK29807.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- FUNCTION: tRNA nucleus export receptor which facilitates tRNA
CC translocation across the nuclear pore complex.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|RuleBase:RU366037}. Nucleus
CC {ECO:0000256|RuleBase:RU366037}. Note=Shuttles between the nucleus and
CC the cytoplasm. {ECO:0000256|RuleBase:RU366037}.
CC -!- SIMILARITY: Belongs to the exportin family.
CC {ECO:0000256|RuleBase:RU366037}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK29807.1}.
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DR EMBL; AKCR02000009; PKK29807.1; -; Genomic_DNA.
DR RefSeq; XP_005499867.1; XM_005499810.2.
DR AlphaFoldDB; A0A2I0MJF9; -.
DR STRING; 8932.A0A2I0MJF9; -.
DR GeneID; 102085482; -.
DR KEGG; clv:102085482; -.
DR CTD; 11260; -.
DR InParanoid; A0A2I0MJF9; -.
DR OrthoDB; 2546268at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0000049; F:tRNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0071528; P:tRNA re-export from nucleus; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR013598; Exportin-1/Importin-b-like.
DR InterPro; IPR045546; Exportin-T_C.
DR InterPro; IPR001494; Importin-beta_N.
DR InterPro; IPR040017; XPOT.
DR PANTHER; PTHR15952:SF11; EXPORTIN-T; 1.
DR PANTHER; PTHR15952; EXPORTIN-T/LOS1; 1.
DR Pfam; PF19282; Exportin-T; 1.
DR Pfam; PF08389; Xpo1; 1.
DR SMART; SM00913; IBN_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU366037};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU366037};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|RuleBase:RU366037};
KW Transport {ECO:0000256|RuleBase:RU366037};
KW tRNA-binding {ECO:0000256|ARBA:ARBA00022555,
KW ECO:0000256|RuleBase:RU366037}.
FT DOMAIN 21..89
FT /note="Importin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00913"
SQ SEQUENCE 962 AA; 109831 MW; 5258F044739F6B39 CRC64;
MDEQALLGLN PNADADLRQR ALAYFEQLKI SQDAWQVCAE ALAQGIYSDD HIKFFCFQVL
EHQVKFKYSE LTEVQQQLIR ETLITWLQAQ MLNPQPEKTF IRNKAAQVFA LLFVTEYLTK
WPKFFFDILS VVDLNPRGVD MYLRILMAVD AELVDRDVVH TSEEARRNTL LKDTMREQCI
PSLVESWYQI LQNYQYNNSE LTCQCLEVVG AYVSWIDLSL IANERFINML LGHMSVEVLR
EEACDCLFEI VNKGMDPIDK TKLVESLCQV LQSAGLFSID QEDDVDFLAR FSKLVNGMGQ
ALIASWTKLI KNGDMKSAQD TLQAIEAKVA LMLQLLIHED DDISSNIIGF CYDYLHILKQ
LSALSDQQKA NVEAIMLAVM KKLTYDEEYN FENEGEDEAM FVEYRKQLKL LLDRLAQVSP
ELLLASVRRV FNTTLQNWQT TRFMEVEVAI RLLYMLAEAL PVSHGAHFSG DVTKATALQD
MMRTLVTSGV SAYQHTSVTL EFFETVVRYE KFFSVEPQHI PTVLMAFLDH RGLRHTSPKV
RSRTAYLFSR FVKSLNKQMN PFIEDVLNRI QDLLELSPPE NGYQALLSSD DQLFIYETAG
VLIVNSEYSA ERKQVLMRNL LTPLMEKFKV LLEKLMMAQD EDRQMALADC LNHAVGFASR
TSKAFSNKQT VKQCGCSEVY LDCLQTFLPA LSCPLQKEVL RSGVRTFLHR MIICLEEEVL
PFIPSASEHM LKDCEAKDLQ EFIPLINQIT AKFKAQVSPF LQQMFMPLLH AIFEVLLLPA
EENDQSAALE KQMLRRSYFA FLQTVTGSGM SEVIANQGAE NVERVLFTVI QGAVDYPDPI
AQKTCFIILS KLVELWGGKD GPVGFADFVY KHIVPACFLA PLKQTFDLAD AQTVLALSEC
AVTLKTIHLK RGPECVQYLQ QEYLPSLQVA PEIIQEFCQA LQQPDAKVFK NYLKVFFQRA
KP
//
