ID   A0A2I0MJN0_COLLI        Unreviewed;       804 AA.
AC   A0A2I0MJN0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 22.
DE   SubName: Full=Patatin-like phospholipase domain containing 8 {ECO:0000313|EMBL:PKK29886.1};
GN   Name=PNPLA8 {ECO:0000313|EMBL:PKK29886.1};
GN   ORFNames=A306_00005036 {ECO:0000313|EMBL:PKK29886.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29886.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK29886.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK29886.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKK29886.1}.
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DR   EMBL; AKCR02000009; PKK29886.1; -; Genomic_DNA.
DR   RefSeq; XP_005508834.1; XM_005508777.2.
DR   AlphaFoldDB; A0A2I0MJN0; -.
DR   STRING; 8932.A0A2I0MJN0; -.
DR   GeneID; 102086355; -.
DR   KEGG; clv:102086355; -.
DR   CTD; 50640; -.
DR   InParanoid; A0A2I0MJN0; -.
DR   OrthoDB; 5477952at2759; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0004620; F:phospholipase activity; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd07211; Pat_PNPLA8; 1.
DR   Gene3D; 3.40.1090.10; Cytosolic phospholipase A2 catalytic domain; 1.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR045217; PNPLA8-like.
DR   InterPro; IPR002641; PNPLA_dom.
DR   PANTHER; PTHR24185; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   PANTHER; PTHR24185:SF1; CALCIUM-INDEPENDENT PHOSPHOLIPASE A2-GAMMA; 1.
DR   Pfam; PF01734; Patatin; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   PROSITE; PS51635; PNPLA; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipid degradation {ECO:0000256|ARBA:ARBA00022963};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT   DOMAIN          467..662
FT                   /note="PNPLA"
FT                   /evidence="ECO:0000259|PROSITE:PS51635"
FT   REGION          126..179
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          333..358
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        133..156
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        342..358
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   804 AA;  91380 MW;  6A5CA53ED64AD4AC CRC64;
     MTVHFSLDTY LFFVINPKRL WWKQRNKYLF FYRPKFSWRI NHAIQQRVFH TSEPRCKWAR
     SRTLWYNKCI YSHDFLYYRV SKLLTSSAKG LTKVNNRMSR IKNTIESVSK AVSSTHSELV
     SRIARLKSHS DTPGKANKSN ADADNFSANL ENAKQVSDAR SQEDCNRGPA AKKSTCVSEN
     SESMLVRSRG TYQDTPEDSV STRNHLFHIS YFSTNFGETF NFVADHINWY FNNSVMDQER
     KRNALLQDLK NEEKNKCDSS ENTEMSEEKI VDSAATLAPE AETLGAEKTN AALPASTKKS
     IANFLSYPSN SVQAFVDSYI GGLVPRLRSD AKVVSQQKSK QPEQKVSEKD EEDKAKEVKA
     AEEREKHLFL QREKIIARVS IDNRTRALVQ ALRRSSNRRI CISRVEELTY HLLEFPESRG
     VAIKEKLIPC LLRLRQANDE SLQAAVRETL AVIGYTDPVK GWGIRVLAID GGGTRGLVAL
     QTLRKLEELT GKPVHQLFDY ICGVSTGAIL AFMLGLFHIP LDDCEELYRK LGSDVFKQNV
     IVGTVKMGWS HAFYDSDIWE KILKEKMGSN LMIETARNSK CPKVAAVSTI VSRGTPLKAF
     VFRNYNHFPG VKSHYIGGCQ YKLWQAIRAS SAAPGYFQEY VLGNDLHQDG GLLLNNPSAL
     AVHECKCLWP DVPLQCLVSL GTGRYESDGK TSVTYTSLKA KLTNVISSAT DTEEVHTMLD
     ALLPPDTYFR FNPLMHEDIP LDESRKEKLN QLQTDGIRYL ERNEEKLRKA AKILTQEKSA
     LHRLQDWLRL KADMYEGLPF LSKL
//