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Database: UniProt
Entry: A0A2I0MJU0_COLLI
LinkDB: A0A2I0MJU0_COLLI
Original site: A0A2I0MJU0_COLLI 
ID   A0A2I0MJU0_COLLI        Unreviewed;       451 AA.
AC   A0A2I0MJU0;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   31-JUL-2019, entry version 10.
DE   SubName: Full=Potassium channel, inwardly rectifying subfamily J, member 4, transcript variant X2 {ECO:0000313|EMBL:PKK29940.1};
GN   Name=KCNJ4 {ECO:0000313|EMBL:PKK29940.1};
GN   ORFNames=A306_00004925 {ECO:0000313|EMBL:PKK29940.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK29940.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK29940.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK29940.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003822};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003822}.
CC   -!- SIMILARITY: Belongs to the inward rectifier-type potassium channel
CC       (TC 1.A.2.1) family. {ECO:0000256|RuleBase:RU003822,
CC       ECO:0000256|SAAS:SAAS00549381}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK29940.1}.
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DR   EMBL; AKCR02000009; PKK29940.1; -; Genomic_DNA.
DR   RefSeq; XP_005514755.1; XM_005514698.1.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005242; F:inward rectifier potassium channel activity; IEA:InterPro.
DR   GO; GO:0034765; P:regulation of ion transmembrane transport; IEA:UniProtKB-KW.
DR   Gene3D; 2.60.40.1400; -; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR041647; IRK_C.
DR   InterPro; IPR016449; K_chnl_inward-rec_Kir.
DR   InterPro; IPR003273; K_chnl_inward-rec_Kir2.3.
DR   InterPro; IPR013518; K_chnl_inward-rec_Kir_cyto.
DR   InterPro; IPR013673; K_chnl_inward-rec_Kir_N.
DR   InterPro; IPR040445; Kir_TM.
DR   PANTHER; PTHR11767; PTHR11767; 1.
DR   PANTHER; PTHR11767:SF53; PTHR11767:SF53; 1.
DR   Pfam; PF01007; IRK; 1.
DR   Pfam; PF17655; IRK_C; 1.
DR   Pfam; PF08466; IRK_N; 1.
DR   PRINTS; PR01326; KIR23CHANNEL.
DR   PRINTS; PR01320; KIRCHANNEL.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Ion channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434609, ECO:0000313|EMBL:PKK29940.1};
KW   Ion transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434639};
KW   Membrane {ECO:0000256|SAAS:SAAS00434581, ECO:0000256|SAM:Phobius};
KW   Potassium {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434575};
KW   Potassium transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434641};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Transmembrane {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00434543, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAAS:SAAS00036756,
KW   ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00036755};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003822,
KW   ECO:0000256|SAAS:SAAS00048561}.
FT   TRANSMEM     84    110       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    188       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        5     48       IRK_N. {ECO:0000259|Pfam:PF08466}.
FT   DOMAIN       49    193       IRK. {ECO:0000259|Pfam:PF01007}.
FT   DOMAIN      200    372       IRK_C. {ECO:0000259|Pfam:PF17655}.
FT   REGION       23     45       Disordered. {ECO:0000256|SAM:MobiDB-
FT                                lite}.
SQ   SEQUENCE   451 AA;  50720 MW;  F87F0AEFDF0ED659 CRC64;
     MGAFSQASQY SVVSTEEDGH KVSALGSMNG HSRNGKGHAP RRKHRNRFVK KNGQCNVYFA
     NLSNKSQRYM ADIFTTCVDT RWRYMLMIFS AAFLVSWLFF GFLFWCIAFF HGDLNAPAVA
     GGPSLLKPCI MHVNSFLGAF LFSVETQTTI GYGFRCVTEE CPLAIMAVVV QSIVGCVIDS
     FMIGTIMAKM ARPKKRAQTL LFSHHAVISV RDGKLCLMWR VGNLRRSHIV EAHVRAQLIK
     PYMTEEGEYL PLDQRDLNVG YDVGLDRIFL VSPIIIVHEI DEESPLYGIG KEELETENFE
     IVVILEGMVE ATAMTTQARS SYLASEILWG HRFEPVVFEE KNHYKVDYSR FHKTYEVAGT
     PCCSARELQE SKMTILPSPP PPSAFCYENE LALVSQDEDE DDDEVGVVLG GNTKEEGGVI
     QMMDFGSHLD LERIQATLPL DTISYRRESA I
//
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