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Database: UniProt
Entry: A0A2I0MK10_COLLI
LinkDB: A0A2I0MK10_COLLI
Original site: A0A2I0MK10_COLLI 
ID   A0A2I0MK10_COLLI        Unreviewed;       513 AA.
AC   A0A2I0MK10;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   13-FEB-2019, entry version 5.
DE   RecName: Full=Hyaluronidase {ECO:0000256|RuleBase:RU610713};
DE            EC=3.2.1.35 {ECO:0000256|RuleBase:RU610713};
DE   AltName: Full=Hyaluronoglucosaminidase {ECO:0000256|RuleBase:RU610713};
DE   Flags: Fragment;
GN   ORFNames=A306_00005081 {ECO:0000313|EMBL:PKK30013.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK30013.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK30013.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK30013.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-
CC         beta-D-glucosamine and D-glucuronate residues in hyaluronate.;
CC         EC=3.2.1.35; Evidence={ECO:0000256|RuleBase:RU610713};
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family.
CC       {ECO:0000256|RuleBase:RU610713}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK30013.1}.
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DR   EMBL; AKCR02000009; PKK30013.1; -; Genomic_DNA.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR017853; Glycoside_hydrolase_SF.
DR   InterPro; IPR018155; Hyaluronidase.
DR   PANTHER; PTHR11769; PTHR11769; 1.
DR   Pfam; PF01630; Glyco_hydro_56; 1.
DR   PIRSF; PIRSF038193; Hyaluronidase; 1.
DR   PRINTS; PR00846; GLHYDRLASE56.
DR   SUPFAM; SSF51445; SSF51445; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR038193-3};
KW   Glycosidase {ECO:0000256|RuleBase:RU610713};
KW   Hydrolase {ECO:0000256|RuleBase:RU610713};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     39     58       Helical. {ECO:0000256|SAM:Phobius}.
FT   ACT_SITE    170    170       Proton donor. {ECO:0000256|PIRSR:
FT                                PIRSR038193-1}.
FT   CARBOHYD    392    392       N-linked (GlcNAc...) asparagine.
FT                                {ECO:0000256|PIRSR:PIRSR038193-2}.
FT   DISULFID     82    375       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    246    262       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    400    411       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    405    462       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   DISULFID    464    473       {ECO:0000256|PIRSR:PIRSR038193-3}.
FT   NON_TER       1      1       {ECO:0000313|EMBL:PKK30013.1}.
SQ   SEQUENCE   513 AA;  59631 MW;  5FEB761480039CF2 CRC64;
     SWDKHISCCK LFHQSFLLFT DFIEDTSKQF PRKKRNMDVW VKWSALTALL TMVNAQLLKP
     TRVPLVLHKP FVVVWNAPTE QCRLRYKVDL DLSVFDIASN TNETLSGSNV TIFYHTHLGY
     YPYYSDNGDP VNGGVPQNES LIKHLNKAKS DIDYCIPMKK FQGLAVIDWE NWRPQWDRNW
     GNKSIYRNKS LEMVRRRHPQ WSEDKIRKVA KEEFENAGKS FMNNTILLAE HMRPNGLWGY
     YLYPDCYNYD YKEHPQRYTG KCPAIESSRN DLLLWLWKES TALYPSIYLD YILKSSPNAL
     KFVHYRVKEA IRIASIARKD YVLPVFVYSR PFYAYTFHVL TEADLVNTIG ESAALGAAGV
     VLWGSMQYAS SKESCSTVKR YIDGPLGHYV INVTSAAKLC SKVLCKKNGR CIRKNSDSSA
     YLHLSPANFK IQTRHSDRGP RFQVTGEPSL ESIEAMRQRF MCQCYQGWTG IFCELPDRNL
     MEHWAHIVFN RSRKQKLYVF LLGVTQLLLH TAH
//
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