ID A0A2I0MK76_COLLI Unreviewed; 471 AA.
AC A0A2I0MK76;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE SubName: Full=Nucleoporin 50kDa, transcript variant X1 {ECO:0000313|EMBL:PKK30083.1};
DE SubName: Full=Nucleoporin 50kDa, transcript variant X2 {ECO:0000313|EMBL:PKK30082.1};
GN Name=NUP50 {ECO:0000313|EMBL:PKK30083.1};
GN ORFNames=A306_00004380 {ECO:0000313|EMBL:PKK30083.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK30083.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK30083.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK30083.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
RN [2] {ECO:0000313|EMBL:PKK30083.1}
RP NUCLEOTIDE SEQUENCE.
RC TISSUE=Blood {ECO:0000313|EMBL:PKK30083.1};
RA Holt C., Campbell M., Edelman N., Keays D., Kapusta A., Domyan E., Suh A.,
RA Carleton J., Warren W., Yandell M., Gilbert M.T., Shapiro M.D.;
RT "Improved genome assembly and annotation for the rock pigeon (Columba
RT livia).";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus, nuclear pore complex
CC {ECO:0000256|ARBA:ARBA00004567}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK30083.1}.
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DR EMBL; AKCR02000008; PKK30082.1; -; Genomic_DNA.
DR EMBL; AKCR02000008; PKK30083.1; -; Genomic_DNA.
DR RefSeq; XP_005509585.1; XM_005509528.2.
DR RefSeq; XP_013224846.1; XM_013369392.1.
DR AlphaFoldDB; A0A2I0MK76; -.
DR STRING; 8932.A0A2I0MK76; -.
DR GeneID; 102085820; -.
DR KEGG; clv:102085820; -.
DR CTD; 10762; -.
DR InParanoid; A0A2I0MK76; -.
DR OrthoDB; 4273059at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProtKB-SubCell.
DR GO; GO:0046907; P:intracellular transport; IEA:InterPro.
DR GO; GO:0051028; P:mRNA transport; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR CDD; cd13170; RanBD_NUP50; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR015007; NUP2/50/61.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR000156; Ran_bind_dom.
DR InterPro; IPR045255; RanBP1-like.
DR PANTHER; PTHR23138:SF141; NUCLEAR PORE COMPLEX PROTEIN NUP50; 1.
DR PANTHER; PTHR23138; RAN BINDING PROTEIN; 1.
DR Pfam; PF08911; NUP50; 1.
DR Pfam; PF00638; Ran_BP1; 1.
DR SMART; SM00160; RanBD; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50196; RANBD1; 1.
PE 4: Predicted;
KW mRNA transport {ECO:0000256|ARBA:ARBA00022816};
KW Nuclear pore complex {ECO:0000256|ARBA:ARBA00023132};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Protein transport {ECO:0000256|ARBA:ARBA00023132};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Translocation {ECO:0000256|ARBA:ARBA00023010};
KW Transport {ECO:0000256|ARBA:ARBA00022816}.
FT DOMAIN 314..471
FT /note="RanBD1"
FT /evidence="ECO:0000259|PROSITE:PS50196"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..148
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 326..348
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 204..248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 249..263
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 471 AA; 50191 MW; 504B67711634FCF9 CRC64;
MAKRIAEKEL TDRNWDQEDE AEEVGTFSVA SEEVLKNRAI KKAKRRNVGS ESESGGAFKG
FKGFILPSGK GGGGFSGFGN GAGIKPLEGL LNGSSSVSST PSFSSLKTTS ETQSAFGSTM
SNGPTTTAFT DKTAASPKAN GGSQPSSSGY AQSKVCSSSV YHKQLAALNC SVRDWIVKHV
NTNPLCDLTP IFRDYEKYLA NIEQQHGSSS DSGSENESNK TPGSQSTVST FGNSKLQQGT
TFLFSNNKTD DTSDKKPEAA PEKKDPSLGA TSTVSFNFGK SVDSSVLGSI GSGTLSSFSF
SPGNSGFFGK DANQTKPASA VSTNILEAQT ESGSNDDKGG EEEEEEPPKV IVNEIKEDDA
FYSKKCKLFY KKDNEFKEKG VGTLHLKPAG NEKTQLLVRA DTNLGNILLN VLIPPKMPCT
RTGKNNVLIV CVPNPPIDEK NPAVPVTMLI RVKTSEDADE LHKILLEKKE A
//
