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Database: UniProt
Entry: A0A2I0MKC8_COLLI
LinkDB: A0A2I0MKC8_COLLI
Original site: A0A2I0MKC8_COLLI 
ID   A0A2I0MKC8_COLLI        Unreviewed;      2638 AA.
AC   A0A2I0MKC8;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   07-NOV-2018, entry version 4.
DE   SubName: Full=Inositol 1,4,5-trisphosphate receptor, type 2 {ECO:0000313|EMBL:PKK30134.1};
GN   Name=ITPR2 {ECO:0000313|EMBL:PKK30134.1};
GN   ORFNames=A306_00004345 {ECO:0000313|EMBL:PKK30134.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK30134.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK30134.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK30134.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK30134.1}.
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DR   EMBL; AKCR02000008; PKK30134.1; -; Genomic_DNA.
DR   RefSeq; XP_013223969.1; XM_013368515.1.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:InterPro.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:InterPro.
DR   GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR000493; InsP3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   PRINTS; PR00779; INSP3RECEPTR.
DR   SMART; SM00472; MIR; 4.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:PKK30134.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2166   2188       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2200   2219       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2240   2264       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2284   2312       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2333   2355       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   2459   2482       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       50    104       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      111    161       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      169    225       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      232    311       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      317    373       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   COILED       27     47       {ECO:0000256|SAM:Coils}.
FT   COILED     2569   2617       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2638 AA;  300492 MW;  75E2861732A14C4A CRC64;
     MNRYSAQKQY WKAKQAKQGN HTEAALLKKL QHAAELEQKQ NESENRKLLG EIVKYSNVIQ
     LLHIKSNKYL TVNKRLPALL EKNAMRVSLD AAGNEGSWFY IQPFWKLRSE GDNVVVGDKV
     VLMPVNAGQP LHASNIELLD NPGCKEVNAV NCNTSWKITL FMKFSSYRDD VLKGGDVVRL
     FHAEQEKFLT CDEYEKKQHI FLRTTLRQSA TSATSSKALW EIEVVHHDPC RGGAGQWNSL
     FRFKHLATGN YLAAELNPHY PEGNNEGKAL QRDGDLPASK KKRQAGEKIM YTLVSVPHGN
     DIASLFELDA TTLQRADCLV PRNSYVRLRH LCTNTWVTST SIPIDTDEER PVMLKIGTCQ
     TKEDKEAFAI VSVPLSEVRD LDFANDANKV LASTVKKLEN GTITQNERRF VTKLLEDLIF
     FVADVPNNGQ EVLDVVVTKP NRERQKLMRE QNILAQIFGI LKAPFKDKGE GSMLRLEDLG
     DQRYAPYKYM LRLCYRVLRH SQQDYRKNQE YIAKNFCVMQ SQIGYDILAE DTITALLHNN
     RKLLEKHITA KEIETFVNLL RRNREPRFLD YLSDLCVSNT TAIPVTQELI CKFMLSPGNA
     DILIQTKLVS TQMDNPLECP VISDDIDEEE VWLYWIDSNK EPHGKAIRHL AQEAKEGTKA
     DLEVLTYYRY QLNLFARMCL DRQYLAINQI SAQLSVDLIL RCMSDESLPY DLRASFCRLM
     LHMHVDRDPQ ESVVPVRYAR LWTEIPTKIT IHEYDSFTDL SRNEMKRKFA LTMEFVEEYL
     KEVVNQPFPF GDKEKNKLTF EVVHLARNLI YFGFYSFSEL LRLTRTLLAI LDIVQVPISS
     YFERLSKFQD GGNNVMRTIH GVGEMMTQMV LSRGSIFPIS APDVQPSIHP SKQASTSDSE
     DVIVMDTKLK IIEILQFILS VRLDYRISYM LSIYKREFGE NNENVESSPA SPPDTPGIAS
     AIVPDIDEIA AQAETMFAGR YILSSFTSLD ELGMTYLRVL IHLIMHDYPP LLSGALHLLF
     KHFSQRAEVL QAFKQVQLLV SNQDVDNYKQ IKADLDQLRL TVEKSELWVE KSTNYESGEV
     GDGQTKGGEE PIEESNILSP IQDGTKKPQI DSNKSNNYNI VKEILIRLSK LCVQNKKCRN
     QQQRLLKNMG AHLVVLDLLQ IPYEKSDEKM NEVMNLAHTF LQNFCRGNPQ NQVLLHKNLN
     LFLTPGLLEA ETMRHIFTNN YLLCNEISER VVQHFVHCIE THGRHVEYLR FLQTIVKADG
     KYVKKCQDMV MTELINGGED VLIFYNDRAS FPVLLQMMCS ERDRADESGP LAYHITLVEL
     LAACTEGKNV YTEIKCNSLL PLDDIVRVVT HDDCIPEVKI AYVNFVNHCY VDTEVEMKEI
     YASNHIWKLF ENFLVDMARV CNTTTDRKHA DTSLEKYVTE PVMNIVSGFF NSPFSDNSTS
     LQTHQPVFIQ LLQSAFRIYN CTWPNPTQKA SVESCIKTLA EVAKNRGIAI PVDLDSQVNT
     LFMKSHSNMV QRAAMGWRMS ARSGPRFKEA LGGPAWDYRN IIEKLQDVVS SLEQQFTPMM
     QAEFSVLVDV LYSPELLFPE GSDARIRCGA FMSKLINHTK KLMEKEEKLC IKILQTLREM
     LDKKTNFAEE GNTLRKILLH RYFKGEYGSG MNGPLSASYS KTAQVGGGFS GQDSDKSGVT
     MCDIQCLLDK EGASELVIDV IVNTKNDRIF SEGILLGIAL LEGGNTQTQY STYQQLKEQK
     KSEKFFKVLY DRMKAAQQEI RSTVTVNTID LGSKKKDDDS DLTVSVPKKR VKDSTLHLKE
     GMKGQLTEAS SATSKAYSVY RREMDPEIDL MGSGTDAANA EEKSTEEAIM SPAIAIMQPI
     LRFLQLLCEN HNRELQNFLR HQNNKTNYNL VCETLQFLDC ICGSTTGGLG LLGLYINERN
     VALVNQTLES LTEYCQGPCH ENQTCIATHE SNGIDIIIAL ILNDINPLGK YCMDLVLQLK
     NNASKLLLAI MESRHDSENA ERILFNMRPR ELVDVMKNAY NQGLECDHEE ENGDDGISPK
     DVGHNIYILA HQLARHNKTL QQMLKPGSDP DEGDEALRYY ANHTAQIEIV RHDRTMEQIV
     FPVPNICEFL TRESKSRVFN TTERDEQGSK VNDFFQQTED LYNEMKWQKK IRNNPPLFWF
     SRHISLWGSI SFNLAVFINL AVALFYPFGD DGDEGTLSPL FSLILWIAVA FCTAMLFFIS
     KPVGIRPFLV SVILRSIYTI GLGPTLILLG AANLCNKIVF LVSFVGNRGT FTRGYRAVIM
     DMAFLYHVAY VLVCMLGLCV HEFFYSFLLF DLVYREETLL NVIKSVTRNG RSIILTAVLA
     LILVYLFSII GFLFLKDDFI MEVDRLKIRT PGAGIGEVPT TTLTSMMGAC AKENCSTSIP
     VINSGEEEED GIERTCDTLL MCIVTVLNQG LRNGGGVGDV LRKPSKDEPL FAARVVYDLL
     FYFIVIIIVL NLIFGVIIDT FADLRSEKQK KEEILKTTCF ICGLERDKFD NKTVSFEEHI
     KSEHNMWHYL YFIVLVKVKD PTEYTGPESY VAQMIVEKNL DWFPRMRAMS LVSNEGDSEQ
     NEIRNLQERL ESTMSLVKQL SSQLAELKEQ MTEQRKNKQR LGFLGSNTPH VNHHMPPP
//
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