ID A0A2I0MMS5_COLLI Unreviewed; 895 AA.
AC A0A2I0MMS5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Toll-like receptor 3 {ECO:0000313|EMBL:PKK30985.1};
GN Name=TLR3 {ECO:0000313|EMBL:PKK30985.1};
GN ORFNames=A306_00003569 {ECO:0000313|EMBL:PKK30985.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK30985.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK30985.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK30985.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the Toll-like receptor family.
CC {ECO:0000256|ARBA:ARBA00009634}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK30985.1}.
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DR EMBL; AKCR02000006; PKK30985.1; -; Genomic_DNA.
DR RefSeq; XP_005500267.1; XM_005500210.1.
DR AlphaFoldDB; A0A2I0MMS5; -.
DR STRING; 8932.A0A2I0MMS5; -.
DR GeneID; 102093907; -.
DR KEGG; clv:102093907; -.
DR CTD; 7098; -.
DR InParanoid; A0A2I0MMS5; -.
DR OrthoDB; 3428126at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
DR GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR GO; GO:0002224; P:toll-like receptor signaling pathway; IEA:InterPro.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR041015; TLR3_TMD.
DR InterPro; IPR017241; Toll-like_receptor.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR24365; TOLL-LIKE RECEPTOR; 1.
DR PANTHER; PTHR24365:SF524; TOLL-LIKE RECEPTOR 3; 1.
DR Pfam; PF13855; LRR_8; 5.
DR Pfam; PF01582; TIR; 1.
DR Pfam; PF17968; Tlr3_TMD; 1.
DR PIRSF; PIRSF037595; Toll-like_receptor; 7.
DR PRINTS; PR01537; INTRLKN1R1F.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00364; LRR_BAC; 5.
DR SMART; SM00365; LRR_SD22; 9.
DR SMART; SM00369; LRR_TYP; 18.
DR SMART; SM00082; LRRCT; 1.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS51450; LRR; 3.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Inflammatory response {ECO:0000256|ARBA:ARBA00023198};
KW Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PKK30985.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..895
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014166725"
FT TRANSMEM 694..715
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 744..888
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 895 AA; 102262 MW; 47A489C273AC990C CRC64;
MGSATLWWSS FSVRLVSICL LCASAGKQCQ IQNEMADCSH LKLTQIPSDL PNNITGLDIS
HNQLRQLGPA NLTKYSQLVY LNAGYNSISK LQPDLCQNVP LLQILRLEHN ELHKLPDRVF
ASCTNLTELN LGYNRIDIKN DPFKALENLN ILDLSHNLLK SANLGLQQQL KNLRELMLNS
NQITELKKKD FSFLSNTSLN SLHLSSNPLK EFHTGCLHAI GNLFGLVMDN VELGENRTKK
LCTELSNTAI QNLSLSHVNL SYIGKSTFQG LQGTNLTVLN LSQNSLSVIE DDSFQWLSSL
QYLSLKHNNI HISSRLFYGL SSLKHLNLIN SLIGKIEDFS FHWLYHLEYL IMDNNNFPGI
TANMFTGLKN LKYLSLCNCN INLQRITNKT FSSLANSSLQ VLNLTKTRIS TIESGAFSSL
GHLKILDLGL NEISQELRGH EFKGLNNIQD IYLSYNKNLT LRSESFIFVP SLRKLMLRKV
GCSNLALSPS PFHPLQNLTV LDISNNNLAN IKEDLFDGLH KLDILDLQHN NLARLWKDAN
PGGPVLFLKD LPNLRILNLK SNGLDEIPVQ VFKGLFQLKD LDLGANNLNL LPATLFDDQN
SLNFLNLQKN LITSVEEKVF GPAFKSLRIL EMDSNPFDCT CESIAWFADW LNVTHTYIPG
LRSQYICNTP PKYHGNQVLH FDSSACKDGA PFKLLFVVTT TTVMLIIFMV LIIHFEGWRI
AFYWNISVNR VLGFKELDRQ QEEFDFDAYV IHARQDKNWV SKNFISLEKN YHFQIRFCLE
ERDFEAGISE FEATVNSIQR SRKIIFVVTE HLLQDPWCKN FKVYHALQQA IEQSRDSIIL
IFLHEIQDYK LYHALHLRRG MFRSRCILNW PAQKERVSAF HQQLVMALKS NSKKQ
//
