ID   A0A2I0MN70_COLLI        Unreviewed;       851 AA.
AC   A0A2I0MN70;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   SubName: Full=Prominin 1, transcript variant X2 {ECO:0000313|EMBL:PKK31127.1};
GN   Name=PROM1 {ECO:0000313|EMBL:PKK31127.1};
GN   ORFNames=A306_00003422 {ECO:0000313|EMBL:PKK31127.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK31127.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK31127.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK31127.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- SUBCELLULAR LOCATION: Cell projection, microvillus membrane
CC       {ECO:0000256|ARBA:ARBA00004475}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004475}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the prominin family.
CC       {ECO:0000256|ARBA:ARBA00006058}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKK31127.1}.
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DR   EMBL; AKCR02000006; PKK31127.1; -; Genomic_DNA.
DR   RefSeq; XP_013227728.1; XM_013372274.1.
DR   AlphaFoldDB; A0A2I0MN70; -.
DR   GeneID; 102089104; -.
DR   CTD; 8842; -.
DR   InParanoid; A0A2I0MN70; -.
DR   OrthoDB; 3538424at2759; -.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0031528; C:microvillus membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR008795; Prominin.
DR   PANTHER; PTHR22730; PROMININ PROM PROTEIN; 1.
DR   PANTHER; PTHR22730:SF3; PROMININ-1; 1.
DR   Pfam; PF05478; Prominin; 1.
PE   3: Inferred from homology;
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           19..851
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5014119493"
FT   TRANSMEM        99..128
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        149..171
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        424..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        474..498
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        787..806
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   851 AA;  94630 MW;  DD92CE8613F8B50D CRC64;
     MAVELCLLLL LLCGSTISEV QPIYKPPPGT LDFGFVPSKM YDTGAYHEPG PIGILFKIVH
     AFLYLVQPNS FPQDLIRKLA QQKFGNTQGD YQKAIYYEIG FIVSAALGLV FILLLPLVGL
     CFCMCRCCDN CGGEMHQRQK KNADCQRSCF ATFLFVASLI ISVGVLCAYA ANQHLTNQVR
     GAKKLVNSNF KDLKIFLNDT PAQIDYLVSQ YNTTKDKALS DLNNVGPLLG SRVQEQLGKE
     VRPALDAALT MAGAIRETKE ALENVSVSVE VLQEGTERLH ANLTDVKTHL SNTLNDSACS
     ATQAASTCNI IRNSLNQLSI HANFSGLPGV SSQLAKVNDV LKIDLSSLVQ KGYAAFNDTP
     DLVVNQTRNI LSDIKNVLDS IGSNITTFTK TLPVQKILAD LTVYLTQSEA YVQDYFPIVE
     QYDFYRWLGC LILCCMLVLI LVFYYLGLLC GTCGYDKHAS PTTRGCISNT GGNFLMAGVG
     FSFLFSWVLM IVVVLTFVTG GNVEKLVCEP FEDKTLFKIL DTPYLLNQHW KNYLSGILFK
     NPDINLTFEK VYSDCKENKG IYTSLQLEHL FNINEFLNIS MYTEDVALKI EHIQINLSKI
     ILLDEIGKEN LLNFSSSGIE GINFAAYLAE INKSVTKVDL LSFANDLEAR ADQLPKGALE
     NALKGHANSI RMIHNQQVVP LEQAMSTLNQ SIRLLKRTSS ELTVKVKNVI SSVNTAQLLI
     NNNASLVIVQ ETKKYMDTIV GYFEQYIEWV KESIAMEVAA CKPIANVIDT AVDIFLCSYV
     TDSVNTFWFG LGGSSIFLIP AIIFAVKLSK YYRRMDTEDV YDDTENGNNG YHKEHLYGIH
     NPVFTSSVEQ W
//