ID A0A2I0MQH7_COLLI Unreviewed; 2064 AA.
AC A0A2I0MQH7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Rho GTPase activating protein 21 {ECO:0000313|EMBL:PKK31935.1};
GN Name=ARHGAP21 {ECO:0000313|EMBL:PKK31935.1};
GN ORFNames=A306_00002509 {ECO:0000313|EMBL:PKK31935.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK31935.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK31935.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK31935.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Cell junction {ECO:0000256|ARBA:ARBA00004282}.
CC Cytoplasm, cytoskeleton {ECO:0000256|ARBA:ARBA00004245}. Cytoplasmic
CC vesicle membrane {ECO:0000256|ARBA:ARBA00004284}; Peripheral membrane
CC protein {ECO:0000256|ARBA:ARBA00004284}. Golgi apparatus membrane
CC {ECO:0000256|ARBA:ARBA00004395}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004395}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK31935.1}.
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DR EMBL; AKCR02000004; PKK31935.1; -; Genomic_DNA.
DR RefSeq; XP_013227585.1; XM_013372131.1.
DR STRING; 8932.A0A2I0MQH7; -.
DR InParanoid; A0A2I0MQH7; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0070161; C:anchoring junction; IEA:UniProtKB-SubCell.
DR GO; GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01253; PH_ARHGAP21-like; 1.
DR CDD; cd04395; RhoGAP_ARHGAP21; 1.
DR Gene3D; 1.20.5.220; -; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR041489; PDZ_6.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23175; PDZ DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23175:SF16; RHO GTPASE-ACTIVATING PROTEIN 21; 1.
DR Pfam; PF17820; PDZ_6; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872}.
FT DOMAIN 122..231
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1021..1130
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1241..1433
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 94..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 428..451
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 635..840
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 875..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 926..1018
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1149..1219
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1442..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1514..1673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1701..1859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1919..1940
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1965..2046
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 435..451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 635..655
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 670..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..747
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 761..793
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 794..810
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 966..988
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1000..1018
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1188
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1189..1214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1446..1460
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1470..1494
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1521..1609
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1615..1669
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1714..1737
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1757..1774
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1832
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1998..2014
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2023..2040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2064 AA; 229629 MW; 2AD801AE7BAA1B72 CRC64;
MSFAQPGAGK AEDVAGWGLR LLKGERTRGN NCSGKRRKAF GGVPVRELGD LFWWGVEGAW
LTVPGRCWLE CGCPRDWCES SELSLLWETS SEASKNKDGK EQSEVISPSE EEETFSWPGP
KTVKLRRTSQ GFGFTLRHFI VYPPESAVQF SFKDEENGNR QGKQRNRLEP MDTIFVKQVK
EGGPAFEAGL CTGDRIIKVN GESVIGKTYS QVIALIQNSD SILELSVMPK DEDILQLLQF
TKDVTALAYS QDAYLKGNEA YSGNAHNIPE PPPICYPRLT STASVKAQAG DKLSSDFSLG
KQQVSRPVRA LAQPERAYRM EIQVPPSPTD IAKSNTAVCV CNETVRTVIV PSEKAVDLPS
CRNNHAGPSH RTEEVRYGLK DQASLKARTT SPPSSVSTAI VLPQTPITRP VDPTGTLSKA
SNYVVCPEGI PSTRPPAQAT DSPSISTNHY SSPTSHQHID WKTYKTYKEY IDNRRMHMYG
SRTIQERLDS LRAASQNTTD YNQVVPNRTA SQVRRRSTSH DRVPQSVQIR QRSVSQERLE
DPVLMKEWPR SASQDTLTSP SVNARNHRAR SWDYLSKQGE VLEKFHSENL IADTNGDRRK
TYKWTGFTEQ DDRRGIYERS RQHAFHMSLR GQNFSMTPSA CISDNRRTGS RASLPGSHFQ
KGPPDIKMLQ SSRDLQTPGG VSKPTAVSQE RLSLTPARSS KSSSLKSSAP YAAKPAFPHN
QGLDAIASKD QRTVNHLHQS GLLNQQSRVR AEGAPDPKTE TGKTIQPSSL SPASARLVQP
TSESLTTSDN MDGSIRQKIH DFKREDVHEP GSPQTGVQEN DKDTVVMRDK SPSGHQTPQP
LRHQSYILAV NDQEAASDTT CWLPNDARRE VHIKRIEERK ASGSSPPGDS LASIPFIDEP
TSPSIDHXXX XXXXSAVISA SASQAPAVTT VPPSPTSPIP LIRRQLSHDH ESIRPSVLDS
QPAAKTERSK SYDEGLDDYR EEGKSSIKHV SSLKGIKVPD SQKSSEDSGS RKDSSSEVFG
DASKEGWLHF RQLVTDKGKR VGGSIRPWKQ LYVVLRGHSL YLYKDKKEQV TPSEEEQPIS
INACLIDISY CETKRKNVFR LTTSDCEYLF QAEDRDNMLA WIKAIQDNSN LNDEDTGVTS
RDLISRRIKE YSTMMSSSSS KTEPSPKTPR QSLSIRQTLL GTKAEQRTQS PHSPKDESDR
KLLTKDETSP PKDKGTWRKG IPSIMRKTFE KKPSAVGTFG VRLDDCPPAH SNKYIPLIVD
ICCKLVEERG LEYTGIYRVP GNNAAISSMQ EELNKGMTDI DVHDDKWRDL NVISSLLKSF
FRKLPEPLFT NDKYADFIDA NRKEDPVERL KTLKRLIHDL PEHHYETLKF LSAHLKTVAE
NSEKNKMEPR NLAIVFGPTL VRTSDDNMTH MVTHMPDQYK IVETLIQKHD WFFTEDDAEE
PLTAVQEENT VESQPVPNID HLLTNIGRTG VSPGDVSDSA TSDSAKSKGS WGSGKDQYSK
ELLVSSIFAA ASRKRKKTKE KPQPSSSEDE LDNVFFKKEL AEQSRGDTTK EDIAKGEYER
ERDIGRKQRM FVLKEKENSS KKDGNVVKDE KKSLKKESVP SEEPSLPYHE KCTKSPNLSC
LQTTQKNNPK TPISQSSQVE ETVSDSGTIL STSSQASQHR YSGKNVTSPE VKHNEFLAAD
VSSITSDYST TSSTIYLTGL DASMMSPEVQ SVTESKGEDA DDERSELISE GRPMETDSES
DFPVFATSAA AERLAKGKAA EAAKTSRRNS EESEVSCTEG SSTPKLESRR LFSSHKLIEC
DTLSRRKSAR HKTDSEGSGD AKSEKDLPTV TKMFDIMKKG RSTSSLATSA RSEADKQEPT
WRLKITDRLK LRLKSSADDM FGVGNQKANS AETTKRKNIR RRHTLGGQRD FAEISVLNAW
KAQEPSQSRE KESELSAVNR LKPKCPAQDL SISDWLARER LRTSTTDLNT GETGKPRLEN
TSLADASKVD LPPSAEMQAD EGSSSSSLTL INRAPPSGPF QPPDQVNGEN YQNMNKNNFS
PAVDAHPHKL SGTQVVRSRF YQYL
//
