ID A0A2I0MQJ1_COLLI Unreviewed; 7725 AA.
AC A0A2I0MQJ1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF, transcript variant X4 {ECO:0000313|EMBL:PKK31953.1};
GN Name=OBSCN {ECO:0000313|EMBL:PKK31953.1};
GN ORFNames=A306_00002385 {ECO:0000313|EMBL:PKK31953.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK31953.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK31953.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK31953.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. {ECO:0000256|ARBA:ARBA00006692}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK31953.1}.
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DR EMBL; AKCR02000004; PKK31953.1; -; Genomic_DNA.
DR RefSeq; XP_013225222.1; XM_013369768.1.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 1.
DR CDD; cd00096; Ig; 13.
DR CDD; cd20971; IgI_1_Titin-A168_like; 1.
DR CDD; cd12025; SH3_Obscurin_like; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 68.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR035526; Obscurin_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR35971:SF4; OBSCURIN; 1.
DR PANTHER; PTHR35971; SI:DKEY-31G6.6; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF07679; I-set; 63.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00612; IQ; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00060; FN3; 1.
DR SMART; SM00409; IG; 66.
DR SMART; SM00408; IGc2; 61.
DR SMART; SM00406; IGv; 15.
DR SMART; SM00015; IQ; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF49265; Fibronectin type III; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 67.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50853; FN3; 1.
DR PROSITE; PS50835; IG_LIKE; 58.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 10..100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..203
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 284..373
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 377..460
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 561..656
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 764..832
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 860..930
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 935..1013
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1039..1105
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1130..1199
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1203..1291
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1314..1383
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1406..1473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1498..1567
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1571..1659
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1665..1751
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1755..1841
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1848..1932
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1936..2029
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2204..2288
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2294..2377
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2382..2473
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2562..2645
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2739..2823
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 2918..3002
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3007..3091
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3187..3271
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3276..3365
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3366..3448
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3453..3537
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3542..3625
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3630..3714
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3719..3803
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3808..3891
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3897..3968
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 3985..4068
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4073..4156
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4161..4232
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4249..4332
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4337..4420
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4425..4509
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4515..4598
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4602..4689
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4694..4778
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4783..4865
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4871..4961
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 4962..5046
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5051..5135
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5140..5230
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5244..5302
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5319..5404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5499..5586
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5590..5674
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 5886..5975
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6133..6222
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6265..6354
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6376..6472
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 6595..6662
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 6688..6873
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 6891..7000
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 7010..7100
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 7104..7194
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 547..568
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5985..6008
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6496..6519
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 6550..6594
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7238..7271
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 7337..7460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6569..6585
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7238..7260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 7376..7455
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 7725 AA; 860630 MW; 843F53512055E93A CRC64;
MDYSSFSGVP RFLTRPKAFM VSVGKDATLS CQIIGNPIPV VSWEKDKLPV QSGGRFKTTE
DGDLYRLTIY DLSLEDSGQY ICRAKNTIGE AFAAVSIKVG EETTVTESAP YFIQKPSSIK
VTLGEDAMFK CKVQGSPPLS VNWEKDGRHL RNRADAGRFQ IQSAGESNAL TIQCARLGDS
GTYTCRAENP IGSASASAAL VVEAQGSSNP GSSSHFDTSC GKTASLLSHL QKRREEIRKM
DISHGGLDST SAHSYSEGLS SFGYGFSRDY ERASGFTTKG ARNATFGTLT RTCSVTEGKH
AKLSCYVTGE PKPEIVWKKD NEVILEGRRH VIYEDDQENF VLKILFCKQT DNGLYTCTAS
NLAGQTYSSV LVTVKEPSIP FKKKLQDLEV REKESATFQC EVPVPSTETA WFKEETKLRQ
SKKYNIEEEG TYRRLTVQNV TTDDDAVYIC EMKEGSRTIA ELSVQGNIIK KLPRKTAVFI
NDTAIFCVEL DNECQNIRWL KNKEEVKPSE RISITCSGKQ HTMIIRECKM EDAGEVAFLA
DESRTSTQFT VTTPKKPPTK PPGDPVVKNK TETSVTLAWS PPKTDRPIPI DGYVVERKKL
TGFTWVRCHE SHVPVPEFTV SDLSEEADYQ FRVSAVNAYG QSPYLEFPGS MHLEPVLAVK
TPLTSVEAVP GGDALFTLDL TKTCSGTWYL NGKVLQESET YIIKRTQTTH TLIIKNVSKN
DDGAEVKFVA NNIDTSTKMR VKGAAVRFTN KSRDIETVSA RLREEAKLQA ELSDAEATVK
WMKDGKELKA SEKYEFQTAG KRHVLKIRNT GTEDAGVYEC VCEGDKMRYQ LSVKALANFI
NKEKTGGVIR ATSGKQAEFV SETSEANIMV KWYKDGKEIT ASKKFTMEDK GKLHKLVASA
VTKEDEGIYT CKIGDDTLIF DLKVSDEAVT FVNKPKMTPE ISVRPSENLE LVCEVSAVSG
AVVWKKDQTE VKQDQRTTIV SQGTHRKLII KKVTQQDQGS YTCETKDDRT TFQVKVRETE
DVFTNKDKVQ KEVKAVLTQN ATLSCEVAQE KTDVKWYKEG KLITSSKKFK VESEGKSRRL
VVGQVEKKDA GEYTCEAAGQ KLTFKIIVTE AEDAFINKDK VKKEVKAALS ENATLSCEVA
QEKTDVKWYK EGKLITSSKK FKVESEGKSR RLVVGQVEKK DAGEYTCEAA GQKLTFKIDV
IEPEVVFTNK DKVKKEVKAA LSENATLSCE VAQEKTDVKW YKEGKLITSS KKFKVESEGK
SRRLVVGQVE KKDAGEYTCE AAGQKLTFKI DVTEAEDAFI NKDKVKKEVK AALSENATLS
CEVAQEKTDV KWYKEGKLIT SSKKFKVESE GKSRRLVVGQ VEKKDAGEYT CEAAGQKLTF
KLNVTEAEDA FINKDKVKKE VKAALSENTT LSCEVAQEKT DVKWYKEGKL ITSSKKFKVE
SEGKSRRLVV GQVEKKDAGE YTCEAAGQKL TFKIIITEAE DAFINKDKVQ KEVKAALSEN
TTLSCEVAQE KTDVKWYKEG KLITSSKKFK VESEGKSRRL VVGQVEKKDA GEYTCEAAGQ
KLTFKIDVTE PEVVFTNKDK VQKEVKAALS ENATLSCEVA QEKTDVKWYK EGKLITSSKK
FKVESEGKSR RLVVGQVEKK DAGEYTCEAA GQKLTFKIDV TEPKPAFINE EKVQKQVNAV
LTESATLSCE VAQEATEVKW YKDGRLLVPS RKFKIETVGK SRRLVVEQLE KKDAGEYICE
AAGQKMTFKL EPTEPEAKFE KKVVQKEPLI VQEHESITLA TSVTPETAAV KWFKDGTEIK
VSKKYEIKSE GASRTLTVNL AESTDTAVYT CQTKTDKQEF KVQVKEIPVK FTKKLEAVNA
ELGGSVCLSC DVSHAKGKVV WCRNGVQIKP SKRFQIHEEG LKRTLTITGI RAEDEGEYSC
ESRDDKSSIT ITPKAPRVVK FVTSLNSVVS EEGKEAVFKC TISPSDAVVT WFRNGVKIEA
SKKYVISQKD TNHSLTITDL TLEDAAEISA NAEGVESKAN LRVREASISF KKKLEPKTVE
ERDTVTLEVE LTKPAEVKWM RNSIVLKPSE KIEIKAEGTK HTLVVKDISF ADRGFYCCES
PDDKTQAKIN VEMRQIKLVK GLQPLEVSEK GTVTFEVEVS HEDVEGTWQK DGVRLKPSPN
INIGVLGKKH SLTLSSVTLE DAGLFSFKAE GIHSSGRLTV KELPVRISKP LVDISATQKD
KVTFECELSR PNVDVKWFKD GKELRQSKKV GIISQGNKRS LIIHKCEYED QGTYKCEAAE
DKTSATLKVH ARDIKIVKPL EDVEVNEYES ASFVCEISHD EVQTQWYKND NKLKAADNIR
MRQEGKTYSL TYTRVQVEDA AEIKFVAEKA ESRAQLTVKE LPVKIVKPLR DKIALEKHRG
FLECQVSRAN AKVKWYKKDV EIHPSDKYEI VSEGVYRKLI INDADYEDED TYTCDAFDDK
SSANFFVEEQ AINIVKELCD EDVTEPEEAN FACEISIPSV KPPKWFLRGE ALQAGRNIIM
QQEGTIHRLT ILKTSTDMTG TVQFSIGKSK STANLRVRDY HIQITRKMED KTALERHSVI
LSCDFRPSPK VVKWFKGHMP IEPSEKYKIK REEHSAELKI LKVKPEDAGV YKCRAGNAET
EATLTVEARN VEVLKHLQDV EIEEESSAVF SCELSHDDED VEWFLNGTLL YTNNFNDIRN
VGNCYTLTMK HVKPEDAGTV TMKSDKVSES VHLKVIEKPA VFMKSLDDVF GEERGVIKLE
CEVSKEKVKP VWKKDGVKLT PGNKYEQIQN GKTLCLLIHD LEKTDAGLYT CDIGTDVAKS
KVSVQELNIG ITKRLKNTEI QEGEDCTFEC ILSHESIGDF NWTLNGNKVG SGGRFKASNA
GRKYTLSITN VIPDDSGEVI FTARGLTSKA SLVVKEKPTE VTKQLEDKTS AAGQDISLSC
ELSKPDVNIR WYKDGKAIRK SQKYDLHQEG TRAILIIHDS TVKDSGEYTC ETEVSKTKAR
VTVQEKPNYF VKELSDLKVD ENGSAVFTCQ SEKAASSVIW RKGMAELRAG RKYEITQKGQ
VLQLTIKNLE KSDSDTYTCD IGDAQSRAKL VVQGQKVLIT EDLEDVTVLE GESAMFKCRI
SPVDYSKVQW FLDKTPLHTN ELNEIQSQPG GYHLLTLKKL SLKDSGVITF EAGDKKTSAS
LVVEEIPVLF KKELQNEEAK EGKQVKLTCE LSKPDTPVKW MKGDTVLYAS EKYEFKQHGT
VAELIIRDVK SVDSGDYTCS TGELKTTARV KVKAVPVLFK QALENTETEE GKSVSLRCEL
SKADATVVWK KGEAALQASA KYEMKQKGTV AELVIHNAEP EDAGRYTCDT GDQQTTAQVK
IHAVSALIEE ELKSVEAVEG GTATLRCQLS REAPVEWRKG HVPLRPSNKY RMRQEGMVVE
LLIHDLDPRD AGDYTCVVGN QKTTAALSVN ALPIRFKREL KNEEATESGT ATLQCELSRA
GGSVEWKKDG KVLMPNGKYK MRREGRFAEL VIQDLDLTDA GSYTCVCGDQ KTTAALRVNA
LPVLFQEELL NKEATEGEAV TLHCKLSKSA PVEWRKGNRV LKPSAKYKIE QEGPFAELVI
QDLDLADAGD YSCVCGNQQT AAALTVNVLP ALFTKELTNK EATEGKSVSL RCELNKAAAN
VEWKKGFKTL KPSDKYKMKR EGVVAELIIQ NLDTTDAGNY SCVCGDQQTT AVLTVHALPA
FFKEGLKNRE ATDGATATLH CELSKVGVPV EWKKGDKTLK PSDKYRMRQE DTAAELLIRD
LEVEDTGEYT CVCGDQKTSA VLTVHALPAL FKKELVDTEA TENGTAVLQC ELTKPTPVEW
RKGPKVLKPS EKYKMRLKDT IAELTIHSLE EQDTGDYTCV CGDKTTTASL TVHALPPRFR
KELRNVEATE DGTAAFCCEL NKPVAAVGWR KGDRALEPSG KFTMRCEGTI AELVIRDLDL
ADAGDYTCCY GDQKTTAALK VNALPTRFKT ELKNEEATEG GTATLQCELS RAASVEWKKK
HKMLKPGEKY TMRQEGATAQ LVIHGLEVKD AGEYTCVCGE EKTTAVLTVH ALPALFKEEL
RNEEATEGEA VTLRCELTKA ASVEWKKGQA LLKPSEKYKM RQKDVTAELV IHNLNESDAG
DYTCVCGDKQ STASLAVHAL PAGIKESLKD EEVTEGQAAT LRCELTKVAQ VEWRKENRLL
KVSDKYKMRQ EGTVMKLLIQ DVELKDAGEY TCVCGEQKTT AALIVHALPA LFKEELKDLQ
ATESQTATLR CELTKAAAVS WKKGNKILRT SEKYTMRQDN ALAELEICDL ELQDAGDYTC
MCGDQHTTAS LTVNALPPLF REELKDREAE EGGEVALHCE LTKAAPVEWR KDQRILKASE
KYKMRQEGTK AELVIREVAE EDAGGYTCVC GEHQTTAVLT VQAVPPFFQE EMTSKEAVEG
GTATLHCELS KAPAHVQWKK DHHVLTPDNK YSMRQERRVV ELVVHDLDVS DTGHYTCVCG
DKTTTAALTV HAIKPRLTQQ LKNEEVEVGG TARLRCEISI SKAEVEWRKD GAVLRPSSKY
EMWQDGTIRE LRVHRLEPGD AGEYSCKAGD ETSSAKLTVK EPDVTIVSGL KDMVVFEGDD
VTFRCQVSHE NARDVEWKLQ DVALQNNEMN EISVEKGKIH TLTLRKVTEQ DIGTITFRVG
PHTSTAELTV KMPPPVFKVK LQSTELREEE TAVLCCEVSQ PNAAVEWKKG AQVIAPSSKY
EIRQEGTIHT LKIYHLKPED SGKYTCDNGN EQTTATLTVK ALPVTFTKPL QNQQAEEGGT
VTLSCEISKS NAAVKWKKAG TVLRPSEKYK MHQTGSVAEL TIRHLSEADG GEYTCDTGDQ
QTTAAVLVKE PAATIVETLK DVTSYEGEDA VFECRLSRET TQDAQWFLGD VPLQSNEMNE
IRVEGTRHTL ILRKVTLEDC GPISFKVGQH TSAAQLTVQV APVSFVKALH NLELQEGGTA
HLSCEVSRPD VPVEWKKGTS VIRSNQKFSI KQEGKVHTLV IQDLNREDSG EYSCHSADGK
TTAKLEVKAL PVLFKHWLKN EEVEEGRTAV LRCELTKPNV PVEWRKGDTV LQPGDKYEMR
QEGTRVELFI YDADAQDVGD YTCDSGDQQT TALLQVKVLP VLFNKELKNI ESEEGGTAVL
HCEISKPDAP VEWRKGGVVI QPSAKYEMKQ KGSVAELIIH GVEPDDCGDY TCSTGYEITT
GSVYVQEEAA VIVSGLKDTD VFVGESATFT CELSHPGVKN VQWWLDGSPL HNNFVTEISE
QDGMVHTLTL NDVACHDSGT VTFRAGSLIS SAKLLVKDPT IEVVSPMQDI TVDEDGTAEF
ICQYSRPVHA IWKKNDQEIH SDGQRVIIDQ DWNVSMLKIK PTVPEDTGIY SCEAEGIKVM
ATLDVQAKNS IVQGLENVEA VEGGEALFEC YLSKPECYNY NWLIDDEPAK TTENTEMVYF
ENGRRHLLLL KNLTPRDSCR VTFMCSDAVT SAFLTVKGWR LQILQPLTDV EVSPGEKVTF
SCVLSEAVPV TEVAWYSNDT EIQSDEDWEV QADGNTYKLI LKKAQPHHSG EVTFASREAI
SSAKLSVIEP PVTVTQPLVG GSVSEGEVAR LECQLSCETE EKVKWFKGKE QIQAGGRYEI
LSDGKKQILI IRAFKPEDQD TYTCMVSPEV KSVASLCLEV PTVTMLKEIA REASPASQPE
ELVDGHVQPS LPPEAAQEGD LHLLWEALAK KRRMSREPTL DSISEVPEED EKLQKLRKEE
AEMSHYYSEE YSTCDELART GEADFSFTSS DEESRAGTPS LVNYLKRAEK KSVSVTSKVQ
SISTGKLWKQ WEKTTVETVM AAPAAKPDEP EMPDLDDPSM NKAAVKIQAA FKGYKVRKEI
KQQECPVFTE TFKDFSGEPG STLHLECVAH SKSDMKVRWL KDGEELSDGR YYHIDNYSDG
TCSLIITGLE RKDAGKYTCE ASNKFGKVSH SAKVVIGAEE PQVLRKEKQV KRSTDSETES
SSGSELDDAF RKAGRRLHRL FRAKISTDIS DVEEELFVSA DEGDIEVVDH QTYREDDQYI
YIKFEILSEA RTAATRFREM FGAMGIPVEI DILEQGPKKI ELRIGKATPP AHGKFAPPVL
RPPPPLLTSD TAPMFITELQ NQEVQDGYPV SFDCIVVGKP LPTVRWFKDG KALEENDHYM
INEDQEGCHQ LIITAVVPTD MGVYRCLAEN NMGVASTKAE LRVDLTSTDY ETAADATETS
SYYSAKEYIS SREQEESATE EEQLPQIFDE LHDIHVAPGA SLAKFHLKVK AYPQPRLYWF
KNGQPLKSSD RILKTHKREF HSLEIRDVTK EDAGQYSIFV INSAGSAYSS ARLVVKDPDE
KEEPSETDSR EQLIPPRFLE RFTNKRVKKG ASITLSVKVE GHPPPAITWM KEESRGDILW
IKPDTPGYKL ASSNMHHSLI LLDVKKKYSG TYTCIATNKA GQSICTATVE VADVKEAEVL
TQERVMVSEA IMTTLGDLHP SETKEGDLEA GRAGVPKSPI SLADVGSEEF FQKLTSRISE
MVSAKISQAT LRVPGAESDD ESKTPSASPR HGRSRPSSIA QESSSESEDG DSRGEIFDVY
MVTADYVPAA PDRETITLKE GQYVEVLDSA HPLKWLVRTK PTKSSPSRQG WVSPAYLDKK
LKLSPEWGTM EVPEFPGEFV SEDEYKRKLS VLIQELLISE EDYIQDLQFL QSHHIKYTEI
CPTVPGAVAS QKATIFRNID DIARFHSSIF LRGLQKCDTD DDVAMCFIKH EAEFDKYIQY
LVGRVQAESI VVSKVVQDFY KRYTDEILTN EDPSQPLIPP LQHYLEKPIN RIQKYQTIIK
ELIRNKARNS QNCTLLEQAY AIVSALTRRA ENNLHVSLIE NYPGTLESLG EPIRQGHFIV
WEGAPGARMA WKGHKRHVFL FKNYIVICKP KRDTRTDTYS YIFKNIMKLN NIDVNDLVEG
DDRAFEIWHE REDLVRKYLL QARTVNIKNS WVKEICGIQQ RISEPVWIPP DFEEELADCT
AELGETVKLA CKVMGAPKPS VSWYKDGKPV EVDPHHIIIE DPDGSCTLIL DNLTGVDSGQ
YMCFASSPAG NASTLGKILV QVPPQFVNKV RNAYFVEGED AQFTCTIEGA PRPQIRWYKD
GVLLKDTNKY QTFSEPRSGM VVLVVKNPSN EDMGHYECEL VNRLGSAKSG AELYHHSAAA
LTQDRRGDQA ITIEVTEQET KVPKKTIIIE ETITTVVKSP RQRGRVSPAR SSSGHSPSRS
PRAEPTPEPV YVSKIRQPVH RHEQEATPKS AVPMLFVTEP EDRQGAAARD VVVETEVEEK
KPKWVEVEEI IEFKVKKSPK PARKRGSSPA KQEKDDSGVL TFTFPSSRPR RSPEDDPNTN
NSNNKLVEQS KSSPNDSLSE PDIQPLVYTS EQEGPQVSNE DRSSPCGSEQ LGNTSFMDHG
TEGRSFPQET SAHYGSDVAS PLLACGGEPL SFSFGTAAAD QHQFLFSPAS PEVKEEVDEL
DVSWPVEEEA PEVMQGVFPE QDNVVIVDEP EEPQIDDIST RERKILTHNG KVLTLEDLED
YVPEEGETYR CDDQKHKAEK PCEISVLQTE INEPTIGKPV LLNLGRPVVS KPRQTFFSQF
EEHVPGGMFM TASRVTGVQS VGPSNISFHV SDACMAVRPG VHAATSAASP GPSFTVKPSF
CTEVQRSADN GQSSFKTEVS TRTLSYGTVG EPVTLHISTE DLSQS
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