ID A0A2I0MRW1_COLLI Unreviewed; 1134 AA.
AC A0A2I0MRW1;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 11.
DE SubName: Full=Fibronectin type III domain containing 3A, transcript variant X2 {ECO:0000313|EMBL:PKK32413.1};
GN Name=FNDC3A {ECO:0000313|EMBL:PKK32413.1};
GN ORFNames=A306_00003226 {ECO:0000313|EMBL:PKK32413.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK32413.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK32413.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK32413.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SIMILARITY: Belongs to the FNDC3 family.
CC {ECO:0000256|ARBA:ARBA00038207}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK32413.1}.
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DR EMBL; AKCR02000003; PKK32413.1; -; Genomic_DNA.
DR RefSeq; XP_005501881.1; XM_005501824.1.
DR AlphaFoldDB; A0A2I0MRW1; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 9.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR PANTHER; PTHR24099; E3 UBIQUITIN-PROTEIN LIGASE TRIM36-RELATED; 1.
DR PANTHER; PTHR24099:SF11; FIBRONECTIN TYPE III DOMAIN-CONTAINING 3BA-RELATED; 1.
DR Pfam; PF00041; fn3; 6.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 6.
DR PROSITE; PS50853; FN3; 9.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1110..1133
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 205..306
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 310..405
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 406..499
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 503..597
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 601..694
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 698..788
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 800..887
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 888..981
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 982..1087
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 125..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 136..183
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1134 AA; 124506 MW; 426F5450015E227B CRC64;
MMSPNGSVPT IYVPPGYAPQ VIEDNGVRRV VVVPQAPEFH PGGHAVIHRP PHPPLPGFLP
LPAMIPPPPR HIYSPVTGAG DMATQYIPQY HTSQVYGDLD TLPAHGRSNF RDERSSKTYE
RLQKKLKDRH GTQKDKLNSP PSSPQKCPSP TSEHNGLTKG QDAAGISTGS TKSKSLGKGK
SNSQTDTEVE EKDEETKALE ALLSNIAKPV VSDIQARTAL LTWSPPSSDT REDADKNDIP
DVYTYEVLIS NTGKDGKYKT VYVGEENKVT VNDLRPATDY HAKVQVECNC VKGSPSEAES
FTTLSCEPDT PNLPRITNRT KNSLTLQWKA SCDNGSKIHS YLLEWDEGKG NGEFCQCYYG
QQKQYRITKL SPAMGYTFRL AAKNDMGMSD FSEEVLYHTS GTAPTTPASP LLMNAGVTWL
SLQWTKPSGT PSDEGISYIL EMEDENSGYG FKPKYDGDDL TYTVKNLRRS TKYKFRVIAY
NSEGKSSPSE TVEYITCPDK PGAPSKPTVK GKIHAQSFKI IWDPPKDNGG AAINTYVVEI
SEGLSGNKWD TIYSGAAREH VCDRLNPGCS YRLRVYCIGE GGQSTASDSL LVQTPAVVPG
PCPPPRLQGR PRAREIQLRW GPPQVDGGSP VTCYGLEMFQ TETDEHREVY QGSDVECTVG
SLLPGRTYNF RLRAANKAGF GPYSEKCEIT TAPGPPDQCK PPQVACRSAA CAQVSWEVPV
SNGADVSEYR LEWGGVEGCM QIAYCGPGLS CEVKGLLPAT IYYCRVQAVN VAGAGPFSEV
VACMTPASVP AVVTCLRGLS EDEVESPYYS PSTCLAISWE KPCDHGSEIL GYSIDFGDKQ
PVTVGKVLSY LIDGLQPDTT YRVRIQALNS LGAGPFSHTI KLKTKPLPPD PPRLECAAYS
SQTLKLKWGE GAAKALTDSI QYHLQMEDKN GRFVSIYRGP CHTYKVQRLS ESTSYKFCIQ
ACNEAGEGPL SQEYVFTTPK SVPAALKAPR IERINDHTCE ITWEVLQPMK GDPVIYCLQV
MVGKDSEFRQ IYKGPDWSFR YTGLQLNCEY RFRVCAVRQC QETAGHQDLV GPYSAPVLFI
SQRTEPPAST NKDTVQTART QWSQSDQVCA AVILALFAIF SILIAVIIQY FVIK
//
