ID A0A2I0MTW0_COLLI Unreviewed; 630 AA.
AC A0A2I0MTW0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Zinc finger CCCH-type containing 12D {ECO:0000313|EMBL:PKK33117.1};
GN Name=ZC3H12D {ECO:0000313|EMBL:PKK33117.1};
GN ORFNames=A306_00000647 {ECO:0000313|EMBL:PKK33117.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK33117.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK33117.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK33117.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SIMILARITY: Belongs to the ZC3H12 family.
CC {ECO:0000256|ARBA:ARBA00010922}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK33117.1}.
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DR EMBL; AKCR02000002; PKK33117.1; -; Genomic_DNA.
DR RefSeq; XP_005507691.1; XM_005507634.1.
DR GeneID; 102092549; -.
DR KEGG; clv:102092549; -.
DR CTD; 340152; -.
DR InParanoid; A0A2I0MTW0; -.
DR OrthoDB; 180910at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd18729; PIN_Zc3h12-like; 1.
DR Gene3D; 3.40.50.11980; -; 1.
DR InterPro; IPR040546; Rege-1_UBA-like.
DR InterPro; IPR021869; RNase_Zc3h12_NYN.
DR InterPro; IPR000571; Znf_CCCH.
DR PANTHER; PTHR12876; N4BP1-RELATED; 1.
DR PANTHER; PTHR12876:SF11; RIBONUCLEASE ZC3H12D-RELATED; 1.
DR Pfam; PF11977; RNase_Zc3h12a; 1.
DR Pfam; PF18039; UBA_6; 1.
DR PROSITE; PS50103; ZF_C3H1; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723, ECO:0000256|PROSITE-
KW ProRule:PRU00723}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|PROSITE-ProRule:PRU00723};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00723}.
FT DOMAIN 279..304
FT /note="C3H1-type"
FT /evidence="ECO:0000259|PROSITE:PS50103"
FT ZN_FING 279..304
FT /note="C3H1-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00723"
FT REGION 323..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 376..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 512..533
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..337
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 630 AA; 71313 MW; AAF4C9EBEA79D543 CRC64;
MPAKMALASS LSSKPVLPHP RKVPTAGVEV HQSKLDFFCK LGYGKQDICK VLENLGQEAL
EDDVLKELIR MGSKPQALEN QAQPSPLKLV ARGSCSTSPG LKWLGGAGGX XXXXXXXVID
GSNVAMSHGN KEVFSCWGIQ LAVDWFRERG HTYIKVFVPL WRKEPPRQDS PISDQHILEE
LEKQSILVYT PCRKVKGKRV VCYDDRYIVK VAYEKDGVIV SNDHYRDLQN ENPEWKWFIE
QRLLMYSFVS NRFMPPDDPL GRHGPTLNNF LSKKPVLPEP KWQPCPYGKK CTYGNKCKFY
HPERPHQAQL SVADELRAKT KVPLNPGKEE EQRNHSPYRT GGEPAPPDVC TETLRKANGY
TGASCYPGWS QGSRPEQLSA TWAGGPSSGL GPDQQLLQPE LLRHQPLLEK MSALSISDDT
YSYNRSIRTS QDREVMDSPH HCSDLRHNLY SFHHPHSSDH TCPFQQTMLP PVQGGMCPER
RWPQECCAVH GVGQRSRYIP AGARHKPALD TQHHVLPQSA AHPPDLPHLY SEHQLQQQQR
FPSQPPRQPF LLDSSNKLGF FQKARAYPHA SYSDYWPTPA ARPPSVQQAN IHRELCSLFP
YGEVNHIMAL YPDIKDIASL TLLIQRHRNL
//
