ID A0A2I0MU79_COLLI Unreviewed; 656 AA.
AC A0A2I0MU79;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 22.
DE SubName: Full=Tumor necrosis factor receptor superfamily, member 21, transcript variant X1 {ECO:0000313|EMBL:PKK33224.1};
GN Name=TNFRSF21 {ECO:0000313|EMBL:PKK33224.1};
GN ORFNames=A306_00001115 {ECO:0000313|EMBL:PKK33224.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK33224.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK33224.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK33224.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00206}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK33224.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AKCR02000002; PKK33224.1; -; Genomic_DNA.
DR RefSeq; XP_005512330.1; XM_005512273.1.
DR AlphaFoldDB; A0A2I0MU79; -.
DR STRING; 8932.A0A2I0MU79; -.
DR GeneID; 102092567; -.
DR KEGG; clv:102092567; -.
DR CTD; 27242; -.
DR InParanoid; A0A2I0MU79; -.
DR OrthoDB; 5348767at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd08778; Death_TNFRSF21; 1.
DR CDD; cd10583; TNFRSF21; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR Gene3D; 2.10.50.10; Tumor Necrosis Factor Receptor, subunit A, domain 2; 2.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR001368; TNFR/NGFR_Cys_rich_reg.
DR InterPro; IPR022330; TNFR_21.
DR InterPro; IPR034037; TNFRSF21_death.
DR InterPro; IPR034034; TNFRSF21_N.
DR PANTHER; PTHR46921; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR PANTHER; PTHR46921:SF1; TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 21; 1.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF00020; TNFR_c6; 2.
DR PRINTS; PR01971; TNFACTORR21.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM01411; Ephrin_rec_like; 2.
DR SMART; SM00208; TNFR; 4.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF57586; TNF receptor-like; 2.
DR PROSITE; PS50017; DEATH_DOMAIN; 1.
DR PROSITE; PS50050; TNFR_NGFR_2; 1.
PE 4: Predicted;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00206};
KW Membrane {ECO:0000256|SAM:Phobius}; Receptor {ECO:0000313|EMBL:PKK33224.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..656
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014147298"
FT TRANSMEM 336..356
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 80..121
FT /note="TNFR-Cys"
FT /evidence="ECO:0000259|PROSITE:PS50050"
FT REPEAT 80..121
FT /note="TNFR-Cys"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DOMAIN 401..484
FT /note="Death"
FT /evidence="ECO:0000259|PROSITE:PS50017"
FT REGION 195..323
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 199..220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 519..537
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 81..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
FT DISULFID 103..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00206"
SQ SEQUENCE 656 AA; 72283 MW; E7A45CB861846DE7 CRC64;
MLMGSLRYGA PAGILELFVL LGTADGQSKL TSEQNTISLP PGKYRHLDRA TNKELICDKC
PAGTYVSKHC TKSTLRECSP CPDGTFTKHE NGIERCHPCR KPCELPMIEK TRCTALTDRE
CTCLSGTFQT NDTCVPYTVC PVGWGVRKKG TETEDVRCKP CPRGTFSDVP SSVMKCKTYT
DCFAKNMVVI KPGTKESDNV CGSPASLPNT SLTSSSTEAD EEPYEVPPTS QLPKGLNSSV
PDFVPSPVPR TSSGTTEPTG YDNETSANET DGAGRTLAGS GITSQAQSYR HKQTSRALEK
QSALEMSGGE KSSMPYRPPR RGQQNVHQHF DINEHLPWMI VLFLLLVLVV IVVCSVRKSS
RTLKKGPRQD PSAIVEKAIM KKSTTPTQNR EKWIYYCNGH GIDILKLVAA QVGSQWKDIY
QFLCNASERE VAAFSNGYAA DHERAYAALQ HWTIRGPEAS LAQLISALRQ HRRNDVVEKI
RGLMEDTTPV QMQPQWQAQD PCKDDTKVEV DRLALPVSPS PLSPAPSPSP KPPEAAVLTV
EPSPSEKKCF FVDEAEPLLR CDSTSSGSSA LSRTGSFITK EKKDTVLRQV RLDPCDLQPI
FDDMLHILNP EELHVIEEIP QAEDKLDRLF EIAGVKSQEA SQTLLDSVYS HLPDLL
//
