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Database: UniProt
Entry: A0A2I0MVC2_COLLI
LinkDB: A0A2I0MVC2_COLLI
Original site: A0A2I0MVC2_COLLI 
ID   A0A2I0MVC2_COLLI        Unreviewed;      4959 AA.
AC   A0A2I0MVC2;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   25-APR-2018, entry version 3.
DE   SubName: Full=Ryanodine receptor 2 (Cardiac) {ECO:0000313|EMBL:PKK33627.1};
GN   Name=RYR2 {ECO:0000313|EMBL:PKK33627.1};
GN   ORFNames=A306_00000529 {ECO:0000313|EMBL:PKK33627.1};
OS   Columba livia (Rock dove).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX   NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK33627.1, ECO:0000313|Proteomes:UP000053872};
RN   [1] {ECO:0000313|EMBL:PKK33627.1, ECO:0000313|Proteomes:UP000053872}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Blood {ECO:0000313|EMBL:PKK33627.1};
RX   PubMed=23371554; DOI=10.1126/science.1230422;
RA   Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA   Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA   Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT   "Genomic diversity and evolution of the head crest in the rock
RT   pigeon.";
RL   Science 339:1063-1067(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PKK33627.1}.
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DR   EMBL; AKCR02000002; PKK33627.1; -; Genomic_DNA.
DR   RefSeq; XP_013224527.1; XM_013369073.1.
DR   Proteomes; UP000053872; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000053872};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000313|EMBL:PKK33627.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4271   4290       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4492   4512       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4566   4585       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4702   4723       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4760   4781       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4836   4859       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      101    156       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      163    208       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      216    271       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      277    334       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      342    399       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    800       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1016   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1348   1553       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4014   4049       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED       66     86       {ECO:0000256|SAM:Coils}.
FT   COILED      463    483       {ECO:0000256|SAM:Coils}.
FT   COILED     3049   3069       {ECO:0000256|SAM:Coils}.
FT   COILED     4410   4430       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4959 AA;  564376 MW;  DBAE7AE8B7056631 CRC64;
     MGTIAKRDDE VVLQCTATVH KEQQKLCLAA EGFGNRLCFL ESTSNSKNVP PDLSICTFVL
     EQSLSVRALQ EMLANTEEKA EGLVDVEKWK FMMKSAQGGG HRTLLYGHAI LLRHSYSGMY
     LCCLSTSRSS MDKLAFDVGL QEDTTGEACW WTIHPASKQR SEGEKVRVGD DLILVSVSSE
     RYLHLSYGNG SLHVDAAFQQ TLWSVAPISS GSEAAQGYLI GGDVLRLLHG HMDECLTVPS
     GEHGEEQRRT VHYEGGAVSI HARSLWRLET LRVAWSGSHI RWGQPFRLRH ITTGKYLSLL
     DDKSLLLTDK EKADVKSTAF CFRSSKEKLD IGTRKEVDGM GAPEIKYGDS ICFIQHVDTG
     LWLTYQSADA KSVRMGSVQR KAIMHHEGHM DDGLTLSRSQ NEESRTARVI RSTVFLFNRF
     IRGLDALSKK AKSSTVDLPI ESVSLSLQDL IGYFHPPDEH LEHEDKQNRL RALKNRQNLF
     QEEGMINLVL ECIDRLNVYS SAAHFADVAG KEAGEAWKSI LNSLYELLAA LIRGNRKNCA
     QFSGSLDWLI SRLERLEASS GILEVLHCVL VESPEALNII KEGHIKSIIC LLDKHGRNHK
     VLDVLCSLCV CHGVAVRSNQ HLICDNLLPG RDLLLQTRLV NHVSSMRPNI FLGISEGSAQ
     YRKWYYELMV DHLEPFVTAE STHLRVGWAS TEGYSPYPGG GAEWGGNGVG DDLYSYGFDG
     LHLWSGCVAR TVNSPNQHLL RTDDVISCCL DLSAPSISFR INGQPVQGMF ENFNIDGLFF
     PVVSFSAGIK VRFLLGGRHG EFKFLPPPGY APCFEAVLPK EKLKVEHSRE YKQDRSYTRD
     LLGPTISLSQ AAFTPVPVDT SQIVLPPHLE RIREKLAENI HELWVMNKIE LGWQYGPVRD
     DNKRQHPCLV EFSKLPEQER NYNLQMSLET LKTLLALGCH VGIADEHAEE KVKKMKLPKN
     YQLLSGYKPA PMDLSFIKLT PSQEAMVDKL AENAHNVWAR DRIRQGWTYG IQQDVKNRRN
     PRLVPYALLD DRTKKSNKDS LREAVRTLLG YGYHLEAPDQ DHAMKLDVCS GIMEKFRIFR
     TEKTYAVKTG KWYFEFEAVT AGDMRVGWTR PGCLPDQELG SDEEAFVFDG FKAQRWHQGN
     EHFGRSWLAG DVVGCMVDMN EHTMMFTLNG EILLDDSGSE LAFKDFEVGD GFLPVCSLGP
     SQVGRMNFGK DVSTLKYFTI CGLQEGYEPF AVNTNRDITI WLSKRLPQFL PVPQNHEHIE
     VMRIDGTIDS CPCLKVTQKS FGSQNSKTDV MFFRLSMPIE CAEVFSRSAA GGLPGSGLFG
     PKNDLEDYDA DSDFEVLMKT AHGHLVPDRT EREKDATKPE LNNHKDYVQE KPSRLKQRFM
     LRRTKPDYSM SHSARLTEDV LADDRDDYDY LMQTSTYYYS VRIFPGQEPA NVWVGWITSD
     FHQYDTSFDL DRVRTVTVTL GDEKGKVHES IKRSNCYMVC AGETMSPGQG RNNNGLEIGC
     LVDAASGLLT FTANGKELGT YYQVEPSTKL FPAVFAQATS PNVFQFELGR IKNVMPLSAG
     LFKSEHKNPV SQCPPRLHVQ FLTHVLWSRV PNHFLKVDVS RISERQGWMI QCLNPLQFMA
     LHIPEENRTI DILELTEQEE LLKFHYHTLR LYSAVCALGN NRVAHAMCSH VDESQLLYAI
     ENKYMPGLLR AGYYDLLIDI HLNTYATARL MMNNEFIVPM TDETKSITLF PDENKKHGLP
     GIGLSTSLRP RMQFSSPSFV SISSECFQFS PEFPLEILKA KTIEMLTEAV QEGSLHVRDP
     VGGSTEFLFV PLIKLFYTLL IMGIFHNGDL KHILQLIEPR VFKEAISQED EADFSEKELS
     SDELKSEEGE EETRREQVPK EGLLQMKLPE PVKLQMCHLL QYLCDCQVRH RIEAIVAFSD
     DFVAKLQENQ RFRYNEVMQA LNMSAALTAR KTKEFRSPPQ EQINMLLNFK DDKNDCPCPE
     EIRDQLLDFH EDLMTHCGIE LDEDGTLDGN SDLTIRGRLL HLMEKVTYLK KKQTEKPVDD
     DDKTSSTLQQ LISDTMVRWA QESVIEDPEL VRAMFVLLHR QYDGIGGLVR ALPKTYTINS
     VSVEDTINLL ASLGQIRSLL SVRMGKEEEK LMIRGLGDIM NNKVFYQHPN LMRALGMHET
     VMEVMVNVLG GGESKEITFP KMVANCCRFL CYFCRISRQN QKAMFDHLSY LLENSSVGLA
     SPSMRGSTPL DVAAASVMDN NELALALREP DLEKVVRYLA GCGLQSCPLL ICKGYPDIGW
     NPVEGERYLD FLRFAVFCNG ESVEENANVV VRLLIRRPEC FGPALRGEGG NGLLAAMEEA
     IQISEDPTRD GRSPSNGSSK TLEMEEQEDD TIHMGNAIMT FYAALIDLLG RCAPEMHLIH
     AGKGEAIRIR SILRSLIPLE DLVGVISIPF HMPTIAKDGT VVEPDMSAGF CPDHKAAMVL
     FLDRVYGIED QDFLLHLLEV GFLPDLRAAA SLDTAALSAT DMALALNRYL CTAVLPLLTR
     CAPLFAGTEH HASLIDSLLH TVYRLSKGCS LTKAQRDSIE ECLLSICGQL RPSMMQHLLR
     RLVFDVPLLN EHAKMPLKLL TNHYERCWKY YCLPGGWGNF GAASEEELHL SRKLFWGIFD
     ALSQKKYEQE LFKLALPCLS AVAGALPPDY MESNYVSMVE KQSSMDSDGN FNPQPVDTSN
     ITIPEKLEYF INKYAEHSHD KWSMEKFANG WTYGETYSES AKVQPLMKQY KLLSEKEKEI
     YRWPIKESLK TMLAWGWRIE RTREGDSMAL YNRTRRISQT SQISVDTAHG YTPRAIDMSN
     VTLSRDLHAM AEMMAENYHN IWAKKKKMEL EAKVGGGNHP LLVPYDTLTA KEKAKDREKA
     QDILKFLQIN GYVVSRGLKD LELDTPSIEK RFAYSFLQQL IRYVDEAHQY ILEFDGGSRG
     KGEHFPYEQE IKFFAKVVLP LIDQYFKNHR LYFLSAASRP LSSGGHASNK EKEMVTSLFC
     KLGVLVRHRI SLFGNDATSI VNCLHILGQT LDARTVMKTG LESVKMALRA FLDNAAEDLE
     KTMENLKQGQ FTHSRNQPKG VTQIINYTTV ALLPVLSSLF EHIGQHQFGE DLILDDVQVS
     CYRILASLYA LGTSKSIYVE RQRSALGECL AAFSGAFPVA FLETHLNKHN IYSIYNTKNA
     RDRAVLNLPT SVEEVCPNIP SLVKLMEEIV ELAESGIRYT QMPHIMEVIL PMLCSYMSHW
     WEHGPENNPD KAEMCCTALT SEHMNTLLGN ILKIIYNNLG IDEGAWMKRL AVFSQPIISK
     VKPQLLKTHF LPLMDKLKKK AAVVVSDEEH LRAEGRGDMS EAELLILDEF TTLARDLYAF
     YPLLIRFVDY NRAKWLKEPN PEAEELFRMV AEVFIYWSKS HNFKREEQNF VVQNEINNMS
     FLISDTKSKM SKAAVSDQER KKMKRKGDRY SMQTSLIVAA LKRLLPIGLN ICAPGDQELI
     ALAKNRFSMK DTEDEVRDII RSNLHLQGKL EDPAIRWQMA LYKDLPNRTE DSSDPEKTVE
     RVLDIANVLF HLEQRSACVG RGYFFWVEHP QRSKKAVWHK LLSKQRKRAV VACFRMAPLY
     NLPRHRAVNL FLQGYDKSWI ETEEHYFEDK LIEDLAKPGE EPAEEDESLK RVDPLHQLIL
     LFSRTALTEK CKLEEDFLYM AYADIMAKSC HDEEDDDGEE EVKSFEEKEM EKQKLLYQQA
     RLHDRGAAEM VLQTISASKG EMGPMVAATL KLGIAILNGG NSTVQQKMLD YLKDKKDVGF
     FQSLAGLMQS CSVLDLNAFE RQNKAEGLGM VTEEGSGEKV MQDDEFTCDL FRFLQLLCEG
     HNSDFQNYLR TQTGNNTTVN IIISTVDYLL RVQESISDFY WYYSGKDVID EQGQRNFSKA
     IQVAKQVFNT LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMQMKLS QDSSQIELLK
     ELMDLQKDMV VMLLSMLEGN VVNGTIGKQM VDMLVESSNN VEMILKFFDM FLKLKDLTSS
     DAFKEYDPDG KGVISKRDFH KAMESHKHYT QSETEFLLSC AETDENETLD YEEFVKRFHE
     PAKDIGFNVA VLLTNLSEHM PHDSRLQTFL ELSESVLNYF QPFLGRIEIM GSAKRIERVY
     FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEKEKMELF VNFCEDTIFE MQLAAQISES
     DLNERSANKE ENEKDKPEEQ DPRMGFFSLM TMKSALVALK YNIVTLMKML SMKSLKKQMK
     KVKKMTMKDM VMALFSSYWS VLMGLLHFAY SVVRGFFRII CSLLLGGSLV EGAKKIKVAE
     LLANMPDPTQ DEVRGEGEEG ERKPTEAALP TEDLTDLRTL SDESDLLSDI FGLDLKREGG
     QYKLIPHNPN AGLSDLLSTP SIAPMPEVQE KVQEQVKEDE KEEKEETKSE PEKAEGEDGE
     KEEKAKEDKG KQKLRQLHTH RYGEPEVQES AFWKKIIAYQ QKLLNYFARN FYNMRMLALF
     VAFAINFILL FYKVSTSAVT EEKDIPVVSA DESTKLDSLE SDNQRVIAVH YVLEESSGYM
     EPTLRILAIL HTVISFFCII GYYCLKVPLV IFKREKEVAR KLEFDGLYIT EQPSEDDIKG
     QWDRLVINTQ SFPNNYWDKF VKRKVMDKYG EFYGRDRISE LLGMDKAALD FSDAREKKKP
     KKDSSLSAVL NSIDVKYQMW KLGVVFTDNS FLYLAWYMTM SVLGHYNNFF FAAHLLDIAM
     GFKTLRTILS SVTHNGKQLV LTVGLLAVVV YLYTVVAFNF FRKFYNKSED GDMPDMKCDD
     MLTCYMFHMY VGVRAGGGIG DEIEDPAGDE YEIYRIIFDI TFFFFVIVIL LAIIQGLIID
     AFGELRDQQE QVKEDMETKC FICGIGNDYF DTVPHGFETH TLQEHNLANY LFFLMYLINK
     DETEHTGQES YVWKMYQERC WEFFPAGDCF RKQYEDQLN
//
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