ID A0A2I0MVN3_COLLI Unreviewed; 1433 AA.
AC A0A2I0MVN3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Laminin, alpha 2 {ECO:0000313|EMBL:PKK33736.1};
GN Name=LAMA2 {ECO:0000313|EMBL:PKK33736.1};
GN ORFNames=A306_00000763 {ECO:0000313|EMBL:PKK33736.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK33736.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK33736.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK33736.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix, basement membrane {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00460}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK33736.1}.
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DR EMBL; AKCR02000002; PKK33736.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0MVN3; -.
DR InParanoid; A0A2I0MVN3; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProt.
DR GO; GO:0005102; F:signaling receptor binding; IEA:InterPro.
DR GO; GO:0030155; P:regulation of cell adhesion; IEA:InterPro.
DR GO; GO:0030334; P:regulation of cell migration; IEA:InterPro.
DR GO; GO:0045995; P:regulation of embryonic development; IEA:InterPro.
DR CDD; cd00055; EGF_Lam; 13.
DR Gene3D; 2.10.25.10; Laminin; 13.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR009254; Laminin_aI.
DR InterPro; IPR000034; Laminin_IV.
DR InterPro; IPR002049; LE_dom.
DR PANTHER; PTHR10574:SF436; -; 1.
DR PANTHER; PTHR10574; NETRIN/LAMININ-RELATED; 1.
DR Pfam; PF00052; Laminin_B; 3.
DR Pfam; PF00053; Laminin_EGF; 16.
DR Pfam; PF06008; Laminin_I; 1.
DR PRINTS; PR00011; EGFLAMININ.
DR SMART; SM00181; EGF; 10.
DR SMART; SM00180; EGF_Lam; 15.
DR SMART; SM00281; LamB; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 11.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01248; EGF_LAM_1; 6.
DR PROSITE; PS50027; EGF_LAM_2; 11.
DR PROSITE; PS51115; LAMININ_IVA; 2.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00460}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Laminin EGF-like domain {ECO:0000256|ARBA:ARBA00023292,
KW ECO:0000256|PROSITE-ProRule:PRU00460};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 1..32
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 33..81
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 102..287
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 321..370
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 371..428
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 429..481
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 482..530
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 620..666
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 667..712
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 713..818
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 833..1067
FT /note="Laminin IV type A"
FT /evidence="ECO:0000259|PROSITE:PS51115"
FT DOMAIN 1108..1156
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DOMAIN 1215..1261
FT /note="Laminin EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50027"
FT DISULFID 8..17
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 52..61
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 340..349
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 399..408
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 453..462
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 465..479
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 482..494
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 484..501
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 503..512
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 620..632
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 640..649
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 685..694
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 713..725
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 789..798
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1127..1136
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1215..1227
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1217..1234
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
FT DISULFID 1236..1245
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00460"
SQ SEQUENCE 1433 AA; 157166 MW; 5EFADD38A18A1B9C CRC64;
MLPGFCHCKT GYAGESCNRC ALGYTGYPEC LPCNCSLEGS VNVDPCVGPC TCKEHVEGEN
CDRCKPGFFN LQQKNPKGCE ECFCSGKTNV CTHSHLTYST IEDMNGWYLT GLPGLIRVVP
KQKQFDGHQQ LSISNVAARK VLPQTYYWSA PSSYLGNKVA AAGGHLKFTV SYDFTEEEET
VQLIVQSDVI IEGGDLRIST PKEGIHLQPS EEHTEEIVLK PESFSVHGTD LPVSRREFMT
VLANVKRILI RATYSNGMNA IYRLRSCSIE AADHTSTGRK VASAVELCDC PPGYDGTSCE
SCWPRHRRVN GTIFGGVCAP CTCFGHAESC DDITGECLDC QHNTGGSYCD RCLPGFYGDP
TKGTAEDCQL CACPLNIPSN NFSPTCHFDR SRGLICDECP AGYVGPRCER CAEGYFGQPL
IPGGSCQPCP CNDNLDFSIP GSCDSLSGAC LICKPGTTGQ YCEKCADGYF GDALDARNCQ
PCHCHINGSF SEICDSRTGQ CECKANVIGR RCGVCKPSYF WAPEKLFCIP CGCSAVGSMS
LRCDMSGRCI CKSGFVGRRC EISRQMPKLK ENARSSSQQI RVPPRRWGVS SASGCPRGAY
RPATPPETFG LQSSRGCVPC NCNSFGSKSF DCDGDGQCYC QPGVTGKKCD RCAHGFYNFE
EGGCTPCECS RFGDNCDPIS GRCICPPNTV GEMCDKCAPN YWGHDIVTGC KPCDCSLIGA
LSSQCDLNTG CCFCRPEFSG DKCTECRLGY WNYPQCVACQ CFLAGTDPQS CETELGRCSC
VDHTGQCSCK VNVEGVHCDR CKSGTFSLSA RNPLGCSSCY CFGLTTQCSE ARGLVRTWVT
LKPEQMILPL VDEKLQRSTL SGIAFQPPEI LANIEQVIQD LRSEPVYWRL PEQFEGRKLT
AYGGKLKYAI YFEAREETGF TTYYPQVIIR GGPPTHPRII VRHMAAPLIG QLTRHEIEMT
EHEWGYYGDD QRVRNTVPWE YYHDDPSVNR TVAQADFTWK YYGDDSRPSR PVSREDFLNV
LYDVHYILIK ATHGNIMRQS RISEISMEVA ESGTVSGVTP QAHLIEKCDC PLGYSGLSCE
SCSPGFYRLS TSPGGRTPAQ SLGVCVLCQC HGHSTMCDPE TSICQNCQHN TAGHHCERCA
LGFYGVVQGS PDDCQPCACP LSNPSNNFSP SCVAEGPSDY RCTACPPGYE GQYCERCSSG
YTGNPQVPGG SCQECECDRY GSLPVPCDPV TGQCTCKPGF TGWKCAGCEH RHARDGMRCI
SCDDECTGLL LSDLDRLNQM ILSVNLSGPL PAPYKMLHGF ENVTQELKHL LSPQQAPERL
LQLAQENLDT LVTEMDELLT RATKVTADGE QTRQDAERTN DRAKSLGQFV KGILQAAEAA
NEDAIKLNET FRTQDETLEK SLPELQSEAD RMIAEMRSRE LNMQERIAQD ELK
//