ID A0A2I0MXD5_COLLI Unreviewed; 3563 AA.
AC A0A2I0MXD5;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 17.
DE SubName: Full=Protein kinase, DNA-activated, catalytic polypeptide {ECO:0000313|EMBL:PKK34341.1};
GN Name=PRKDC {ECO:0000313|EMBL:PKK34341.1};
GN ORFNames=A306_00001517 {ECO:0000313|EMBL:PKK34341.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK34341.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK34341.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK34341.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family.
CC {ECO:0000256|ARBA:ARBA00011031}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK34341.1}.
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DR EMBL; AKCR02000001; PKK34341.1; -; Genomic_DNA.
DR STRING; 8932.A0A2I0MXD5; -.
DR InParanoid; A0A2I0MXD5; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR046804; DNA-PKcs_N.
DR InterPro; IPR046803; DNAPKcs_CC1-2.
DR InterPro; IPR012582; DNAPKcs_CC3.
DR InterPro; IPR045581; DNAPKcs_CC5.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF68; DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; 1.
DR Pfam; PF20500; DNA-PKcs_N; 1.
DR Pfam; PF20502; DNAPKcs_CC1-2; 1.
DR Pfam; PF08163; DNAPKcs_CC3; 1.
DR Pfam; PF19704; DNAPKcs_CC5; 1.
DR Pfam; PF02259; FAT; 1.
DR SMART; SM01344; NUC194; 1.
DR SUPFAM; SSF48371; ARM repeat; 3.
DR PROSITE; PS51189; FAT; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:PKK34341.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW Transferase {ECO:0000313|EMBL:PKK34341.1}.
FT DOMAIN 2913..3545
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT REGION 592..611
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3563 AA; 406761 MW; F73CC630AEC6A6B3 CRC64;
MAGVQESLLE LHRCLQPGDA GAAMHXXXGG GVGVCGVSAA LSEARALHLS LVFSQQHGLL
VFIHRSLGIE EFRDCREEAL KFLCVFMEKV GDEVHPYACN IKKTCVSVYT KDRAAKCKIP
ALELLIKLLR SLQRSCLMEE MKVGEIFNKF YGELATKSKI PDTVLEKIYE LLGVLGQVQP
SDMINNSEKL FRAYLGELKT QMTSATRAPK LPVVVGCLRG LAALMYNFTK SVDEDPQTAK
EIFDFAMRAI NPQVDQKRYA VHLAGLQLFI WHAAQFGALL LDNYVSLFEV MWKWCGHTNQ
ELKKTSNSAL DSFLKQISLM IAQDAERHKN KLQFFMEQFY AIIRRMDSSN KELSIAIRGY
GLFAAPCKAI HSKDVDDMYV ELLQRCKQMY LTEAETIDDH LYQLPSFLQS IASVILHIDT
IPEVYTPVLE HLVVLQINSF PQHSEKMQLV CCRSIIKVFL ALSGKGPVLW SFVSTVVHQG
LIRIFSKPIT FSKDFFGKGT SGSEDSREAA EVETGRWKVP TYKDYLYLFR SLLNCDTMKE
CVFEDENFLT ANTPLQSLNR LLYDELLKSI LKIIEKLDLT VQRLDVNEQD ENETDGALVG
PTSDPASNLQ PTKPTDFIAF INLVEFCREI LPEKHVEYFN PWVYSFGYEL IIHSTRLPLI
SGFYKLLSVT MKIAKKIKYF EGVSPQSVRK CPEDPEKRSC FALFAKFGKE VTAKMKQYKD
ELLASCLNFL LSLPHEIIML DIKAYIPALQ NAFKLGLSCT PMANLGLDAL EDWSAHIPRH
IMQPYYKDVL PLLDGYLKNS ASTAESQNNW EIRKLSRAAQ KGFNKVVIQR LRKAKTFSWD
DSSSLEAVRA RVARLLGSLG GQINHNLITA ASAEEMMKKC VSWDTEKRLS FAVPFADMKP
VIYLDLFLPR VTELALSASD RQTKVAACEL LHSIVTYMLG KASQMPEGCQ GPPPMYQLHK
RIFPVLLRLA CDVDQVTRQL YEPLVMQLIH WFTNNKKFES QDTVVFLEAI LSGIVDPVDS
TLRDFCGQCV QEFLKWSIKQ TTPRQQERSP VNTKSLFKRL YSLALHPSAF KRLGAALAFN
SIYREFREEN SLVEQFVFEA LVVFLESLAL THTDEKSLGT TQQCCDAINH LKRIIKHKAP
SLNKEGKRRV PRGFPATKSV CLQDVVMWLL VQCGRPQTEC RHKSMELFYE FVPLLPGNKS
PSSWLADVLK EQDVSFLINK FEGGGSDAKS PSGILSQPTL HGMQEPFSLQ TVMRWMDMFL
AALDCYNTFS ELRMIKPHEI LCVDERSSFL EAVQFFLETI ALHDIHAAEK YFDCSSKGST
FSPQEKDVYN YSKCTIIVRI MEFVTMILET CPQDFWKLLE KELLNANLIE LLVMTVCDPS
HVGFNIADVQ VMKNLPDISV RLMKALMKSP YKESLKLCIK KRITPQSLED LCSVDLFNSD
ARFDQVRLSA VLSACKQLQK SGLLHSVLHN QDGGSHFSVG SKLLSVVYKS IAPGDEGIAL
PSLDISSKQL ADRLLQLAFA IDDQCEELVS LLLNTVVLSV PLSGASQKNL INFSHGQYFY
SLFSETINQQ LLKNLDVIVV QLMESSVSNP QMVSSILNGM LDQSFRERTV RKQQGAKLVT
AVLRNWRKLD SWWAKGSSPE SKMAILTLLA KVLQIDSSVS FNTNHEAFTA VFNTYTSLLT
DQDLGLNLKG QAVIILPFFT NLTGEKLNDL KNALDQLVAF NFPMRSDEFT KGTLRHNNYV
DCTKKFLDAL ELSQSPMLLQ LMTEVLCRDR RHCVEDLFQA SFERISRRST TDKQVILLDT
VHKMFQREEL LSNKTRQAFV DRSLLTLLWH CSLDALREFF GKIIVQAMDT LNSRFTKSNE
CIFYTQVTKK MGYYKLLEVM YVRLSKEDVY SKDSKINQAY RGSMSVEGNE LTKTLIKSCY
DAFTENMAGE GLLLEERRQY HCAAYNCAIA VISCVFTESK FYQGFLFTEK PEKNLLIFEN
LIDLKHQYMF PVEIEVPLER KKRYIAIRKE ARDAGNSDQD EPKYLASASY MMDSSLSEEM
SQFDFSTGVQ GFSYSSQDVT ATSTRFRRKE PTEYMVLNDE MELEMDELNQ HECMASLTTL
IKHMQRNQIT PKVEEGTLPV DLPLWMKFLH GKLGNPSVPL NIRLFIAKLI VNTEDVFRPY
AKQWLGPLLQ LVVSGNNGGE GIHYMVVEIV VTILSWTSVA TPKGSIKDEI LANRLLEFLM
KNAFHQERAV FRHNLEIIKT VIECWKNCLS IPYSLIFEKF SSGDPDTKDN SVGIQLLGIV
LANNLPPFDP KCEIDRVRYF QALASNMGLL KYKEVYAAAA EVLGLALHYL AEREDVLEDP
VYDCVIRQLK QHQNTQQDKF IQCLNKVVKN FPPLADRFMN AVFFLIPKLH GVMKTYCLEV
IMCQAEEIPD LHLQLKTKDF TQIMNHRDDE RQRVCLDIVY KMLSKLKPLE LKELLPAVSG
FISHPSVICR QRMYDILMWI YDNYSDPESQ ADGDSQEILK LAKEILVQGL IDENAELQLI
VRNFWSYETR LPANIPDRML VLLNSLYSTK IETQYLSLIT NFLLEMTSKS PDYSRKIFEH
PLSECKFQDF VIDSSWRYRS TILTPMFVET QASQSIHRNL SEERSLSASG SVGGRVRATQ
RQYEFTPTQH VSGRSSFNWM TGSSIDTLAE YTVPSSSESV SSSMLLVKKR SEKFKQAAFK
PVGPDFGKKR LGLPGDEVDS KTKGIEERAE ILRLQRRFLK DKRKLSLIYA RKGVAEQKRE
QEMKSELKMK CDAQVTLYRR YRVGDLPDIQ IEYRSLIAPL QGLAQKDPTF AKQLFSSLFG
GIFHEVEKSK SPSEKTSIVQ KLLNDFNNFL SMSQSYFPPF IACIQEMSYQ HRELLELDSA
NVSTSCLASL QQPVGILLLE RALMALSPAQ EPPSKRMRGR TELPPDVIRW IELAKLYRSL
GDYDVLRGIF SGKIGTKEIT QKALLAEARS DYAEAAKYYD EALSKEDWQD GEPAEVEKDF
WELASLECYD HLTEWKSLEH CATINIDSGK PPDLSKTWSD PFFQETYLPY IIRSKLKLLL
NGENDQTLLT FIDEAMKTEQ KKAIIEMHYS QELSLLYILQ NDFDRAKYYI SNGMQIFMQS
YSSIDSLLYQ SRMTKLQSVQ ALTEIQDFIN FMTKRSNLAS QASLKRLLRI WTSRYPDAKM
DPMNIWDDII TNRCFFLDKL QEKLLCDQAN DSMEVDKEYD AGDQMEVDQQ DEDICSMIKS
CKFNMKMKML ESARKQNSFS VAKKLLKDLR KDTKTREDWL VRWNHAYCRF MHSCSWNQSC
PERVLSVLKT ISLLEDTKSD YVSKNIMASR NQNLLLGTTY HIMANALSQD PRCLKEIGEE
KAGKISVVSG ESLESPEKVL AGLNKKAFQS FSSAARKSEE EVQSRSMEHV DVMGVIDAYM
TLVGFCDQHL RREEEGLLEI STADLQLFPA IVVEKMIKAL KLNSREARLR FPRLLQIIER
YPAETLGLVT RELSSVPCWQ FIGWISQMMA LLDKDEAVAV QHTVEEIANT YPQAIIYPFM
ISSESYCFKD TAAGCKNKEF VER
//
