ID A0A2I0MXJ8_COLLI Unreviewed; 590 AA.
AC A0A2I0MXJ8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Growth factor receptor-bound protein 10 {ECO:0000313|EMBL:PKK34393.1};
GN Name=GRB10 {ECO:0000313|EMBL:PKK34393.1};
GN ORFNames=A306_00001717 {ECO:0000313|EMBL:PKK34393.1};
OS Columba livia (Rock dove).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Columba.
OX NCBI_TaxID=8932 {ECO:0000313|EMBL:PKK34393.1, ECO:0000313|Proteomes:UP000053872};
RN [1] {ECO:0000313|EMBL:PKK34393.1, ECO:0000313|Proteomes:UP000053872}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Blood {ECO:0000313|EMBL:PKK34393.1};
RX PubMed=23371554; DOI=10.1126/science.1230422;
RA Shapiro M.D., Kronenberg Z., Li C., Domyan E.T., Pan H., Campbell M.,
RA Tan H., Huff C.D., Hu H., Vickrey A.I., Nielsen S.C., Stringham S.A.,
RA Hu H., Willerslev E., Gilbert M.T., Yandell M., Zhang G., Wang J.;
RT "Genomic diversity and evolution of the head crest in the rock pigeon.";
RL Science 339:1063-1067(2013).
CC -!- SIMILARITY: Belongs to the GRB7/10/14 family.
CC {ECO:0000256|ARBA:ARBA00006708}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK34393.1}.
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DR EMBL; AKCR02000001; PKK34393.1; -; Genomic_DNA.
DR RefSeq; XP_005507568.1; XM_005507511.1.
DR STRING; 8932.A0A2I0MXJ8; -.
DR GeneID; 102084727; -.
DR KEGG; clv:102084727; -.
DR CTD; 2887; -.
DR InParanoid; A0A2I0MXJ8; -.
DR OrthoDB; 3144731at2759; -.
DR Proteomes; UP000053872; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01259; PH_APBB1IP; 1.
DR CDD; cd16141; RA_GRB10; 1.
DR CDD; cd10415; SH2_Grb10; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR039664; GRB/APBB1IP.
DR InterPro; IPR035037; Grb10_SH2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039665; PH_APBB1IP.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000159; RA_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR PANTHER; PTHR11243; GROWTH FACTOR RECEPTOR-BOUND PROTEIN; 1.
DR PANTHER; PTHR11243:SF4; GROWTH FACTOR RECEPTOR-BOUND PROTEIN 10; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00788; RA; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00233; PH; 1.
DR SMART; SM00314; RA; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50200; RA; 1.
DR PROSITE; PS50001; SH2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Receptor {ECO:0000313|EMBL:PKK34393.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000053872};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 166..250
FT /note="Ras-associating"
FT /evidence="ECO:0000259|PROSITE:PS50200"
FT DOMAIN 292..401
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 489..585
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT REGION 80..114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 80..111
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 67016 MW; B36C50CCCEE09489 CRC64;
MALAGCPDSF LHLPYRIDNV DQTSAHGRRD LVEPGFQEPS NRISLSHQDD DVDLEALVND
MNSSFESLYS ACSMQSESTP LLQNGQLSRS QLGSSGPGAL QPLSPRQKVQ RSQPVRIMAV
RRLQEEEQQF RTSSLPAIPN PFPELCSPAS SPVLAPGSLP QSQPASKHDV KVFSEDGTSK
VVEILADMTA RDLCQLLVYK SHCVDDNSWT LVEHHPHLGL ERCLEDHELI VQVESTMGSE
SKFLFRKNYA KYEFFKNPVN FFPEQMVAWC QQTNGSIPQS QLLQNFLNSS SCPEIQGFLH
VKELGRKSWK KLYVCLRRSG LYCSTKGTSK EPRHLQLLAD LEDSNIFSLI AGKKLYNAPA
EYGFCIKPNR VRNETKELRL LCAEDEQSRT CWMTAFRLLK YGMLLYQNYR IPQQRKAMLP
HFSTPVRSVS ENSLVAMDXX XXXXXXXXSA ALEEGHAWRK RSTRMNILGS QSPLHPSTLS
TVIHRTQHWF HGRISREESH RIIKQQGLVD GLFLLRDSQS NPKAFVLTLC HHQKIKHFQI
LPCEDDGQIF FSLDDGNTKF SDLIQLVEFY QLNKGVLPCK LKHHCIRVAL
//
