ID A0A2I0MYM3_9CLOT Unreviewed; 522 AA.
AC A0A2I0MYM3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=uroporphyrinogen-III C-methyltransferase {ECO:0000256|ARBA:ARBA00012162};
DE EC=2.1.1.107 {ECO:0000256|ARBA:ARBA00012162};
GN ORFNames=ABB02_01906 {ECO:0000313|EMBL:PKK38818.1};
OS Clostridiaceae bacterium JG1575.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae.
OX NCBI_TaxID=1658742 {ECO:0000313|EMBL:PKK38818.1, ECO:0000313|Proteomes:UP000237298};
RN [1] {ECO:0000313|EMBL:PKK38818.1, ECO:0000313|Proteomes:UP000237298}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JG1575 {ECO:0000313|EMBL:PKK38818.1,
RC ECO:0000313|Proteomes:UP000237298};
RA Nelson M.C., Graf J.;
RT "Draft genome of Clostridiaceae bacterium JG1575.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the precorrin methyltransferase family.
CC {ECO:0000256|RuleBase:RU003960}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK38818.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LQGW01000060; PKK38818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0MYM3; -.
DR OrthoDB; 9815856at2; -.
DR Proteomes; UP000237298; Unassembled WGS sequence.
DR GO; GO:0004851; F:uroporphyrin-III C-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004852; F:uroporphyrinogen-III synthase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0019354; P:siroheme biosynthetic process; IEA:InterPro.
DR CDD; cd06578; HemD; 1.
DR CDD; cd11642; SUMT; 1.
DR Gene3D; 3.40.50.10090; -; 2.
DR InterPro; IPR000878; 4pyrrol_Mease.
DR InterPro; IPR035996; 4pyrrol_Methylase_sf.
DR InterPro; IPR036108; 4pyrrol_syn_uPrphyn_synt_sf.
DR InterPro; IPR003754; 4pyrrol_synth_uPrphyn_synth.
DR InterPro; IPR014777; 4pyrrole_Mease_sub1.
DR InterPro; IPR014776; 4pyrrole_Mease_sub2.
DR InterPro; IPR006366; CobA/CysG_C.
DR InterPro; IPR003043; Uropor_MeTrfase_CS.
DR NCBIfam; TIGR01469; cobA_cysG_Cterm; 1.
DR PANTHER; PTHR45790:SF3; S-ADENOSYL-L-METHIONINE-DEPENDENT UROPORPHYRINOGEN III METHYLTRANSFERASE, CHLOROPLASTIC; 1.
DR PANTHER; PTHR45790; SIROHEME SYNTHASE-RELATED; 1.
DR Pfam; PF02602; HEM4; 1.
DR Pfam; PF00590; TP_methylase; 1.
DR SUPFAM; SSF69618; HemD-like; 1.
DR SUPFAM; SSF53790; Tetrapyrrole methylase; 1.
DR PROSITE; PS00839; SUMT_1; 1.
DR PROSITE; PS00840; SUMT_2; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:PKK38818.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000256|RuleBase:RU003960};
KW Porphyrin biosynthesis {ECO:0000256|ARBA:ARBA00023244};
KW Reference proteome {ECO:0000313|Proteomes:UP000237298};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003960}.
FT DOMAIN 18..230
FT /note="Tetrapyrrole methylase"
FT /evidence="ECO:0000259|Pfam:PF00590"
FT DOMAIN 280..501
FT /note="Tetrapyrrole biosynthesis uroporphyrinogen III
FT synthase"
FT /evidence="ECO:0000259|Pfam:PF02602"
SQ SEQUENCE 522 AA; 55712 MW; D805739A3CE82555 CRC64;
MTIDWRSLED QTLHPGGKVT LVGAGPGSAS LLTLRGKECL ERAEVAFVDR LVGSELLHFL
PSTCEVVDVG KREGHHPVPQ QTINRWIEQA ARAGLEVVRL KGGDPYIFGR GGEELEGLLA
RGIPFEVVPG ITSSIACASY AGIPLTHRGL SQSFHVITAH AKANEDPKVP YEALVATGGT
LVFLMGVSAL AAIQKGLLLA GMDPCLPAAI VERGTHPAQR KVLAPLRDLA QAAQRASIVS
PAIVIVGKVA ALSESLDWFS HRPLHGKKVV VTRAREKASE LRRSLEELGA QVLEVPSIKS
RSLPAPADGA ALWPTFGQSA QWLVFTSARG VQGFFEWLDA AALDARALSL CRFACVGRET
ALALKEHGLR ADLVPQTYSG EALAQELIAQ RRPEERVLIL RAKEGSATLT EALTAAGIAY
REIPVYETLW DPGAVRLEQA SACDAITFAS AATVEGFCRS YPTFDPHSMP AICIGEQTAK
AARGKGFNPI LSQKATMDSM AACVKEVLTH DDDPTSPASA QQ
//
