ID A0A2I0MZU3_9CLOT Unreviewed; 320 AA.
AC A0A2I0MZU3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=3-oxoacyl-[acyl-carrier-protein] synthase, KASIII {ECO:0000313|EMBL:PKK39275.1};
DE EC=2.3.1.180 {ECO:0000313|EMBL:PKK39275.1};
GN ORFNames=ABB02_01507 {ECO:0000313|EMBL:PKK39275.1};
OS Clostridiaceae bacterium JG1575.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae.
OX NCBI_TaxID=1658742 {ECO:0000313|EMBL:PKK39275.1, ECO:0000313|Proteomes:UP000237298};
RN [1] {ECO:0000313|EMBL:PKK39275.1, ECO:0000313|Proteomes:UP000237298}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JG1575 {ECO:0000313|EMBL:PKK39275.1,
RC ECO:0000313|Proteomes:UP000237298};
RA Nelson M.C., Graf J.;
RT "Draft genome of Clostridiaceae bacterium JG1575.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Lipid metabolism. {ECO:0000256|ARBA:ARBA00005189}.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. FabH family.
CC {ECO:0000256|ARBA:ARBA00008642}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKK39275.1}.
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DR EMBL; LQGW01000052; PKK39275.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0MZU3; -.
DR OrthoDB; 9815506at2; -.
DR Proteomes; UP000237298; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0033818; F:beta-ketoacyl-acyl-carrier-protein synthase III activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00830; KAS_III; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR InterPro; IPR013747; ACP_syn_III_C.
DR InterPro; IPR013751; ACP_syn_III_N.
DR InterPro; IPR004655; FabH.
DR InterPro; IPR016039; Thiolase-like.
DR NCBIfam; TIGR00747; fabH; 1.
DR PANTHER; PTHR34069; 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE 3; 1.
DR PANTHER; PTHR34069:SF2; BETA-KETOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III; 1.
DR Pfam; PF08545; ACP_syn_III; 1.
DR Pfam; PF08541; ACP_syn_III_C; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000313|EMBL:PKK39275.1}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW Fatty acid metabolism {ECO:0000256|ARBA:ARBA00022832};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000237298};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:PKK39275.1};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 296..315
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 104..169
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III N-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08545"
FT DOMAIN 228..317
FT /note="Beta-ketoacyl-[acyl-carrier-protein] synthase III C-
FT terminal"
FT /evidence="ECO:0000259|Pfam:PF08541"
SQ SEQUENCE 320 AA; 34748 MW; 56313735F8054A23 CRC64;
MSFYIAGTGR AEPEFILDNA MLEELVETSD EWITQRTGIK ERHILREETM RSLAHHAAQE
ALADAGIMAS ELDLIVFATV GGDYRTPSQA SIVSMDLGVK CPAMDLNAAC TGFLYALDVA
DAYFQAGKAS CILVVAMEIM SRFTDYSDRR TCVLFGDGGG AVVLKKGEGL KALHLSGEGN
IEPLYIPNLF TPTPWRKEAP QKGTVAMKGP QVYQFAVGAF LREMDQCLSA AHLTAKDLDL
IIPHQANARI IESARVKWGL PHEVFINEVA RRGNTSSGSI PLLLDELNRS GRLKEGMLLA
LVAFGGGMTS GGAILKWQKN
//
