ID   A0A2I0P496_9EURY        Unreviewed;      1290 AA.
AC   A0A2I0P496;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   RecName: Full=BIG2 domain-containing protein {ECO:0000259|SMART:SM00635};
GN   ORFNames=CVV31_13635 {ECO:0000313|EMBL:PKL61020.1};
OS   Methanomicrobiales archaeon HGW-Methanomicrobiales-2.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanomicrobiales.
OX   NCBI_TaxID=2013818 {ECO:0000313|EMBL:PKL61020.1, ECO:0000313|Proteomes:UP000233573};
RN   [1] {ECO:0000313|EMBL:PKL61020.1, ECO:0000313|Proteomes:UP000233573}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HGW-Methanomicrobiales-2 {ECO:0000313|EMBL:PKL61020.1};
RX   PubMed=28350393; DOI=10.1038/ismej.2017.39;
RA   Hernsdorf A.W., Amano Y., Miyakawa K., Ise K., Suzuki Y., Anantharaman K.,
RA   Probst A., Burstein D., Thomas B.C., Banfield J.F.;
RT   "Potential for microbial H2 and metal transformations associated with novel
RT   bacteria and archaea in deep terrestrial subsurface sediments.";
RL   ISME J. 11:1915-1929(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKL61020.1}.
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DR   EMBL; PGYL01000055; PKL61020.1; -; Genomic_DNA.
DR   Proteomes; UP000233573; Unassembled WGS sequence.
DR   Gene3D; 2.60.40.1080; -; 8.
DR   Gene3D; 2.120.10.30; TolB, C-terminal domain; 2.
DR   InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR   InterPro; IPR027618; Beta_prop_Msarc.
DR   InterPro; IPR003343; Big_2.
DR   InterPro; IPR008964; Invasin/intimin_cell_adhesion.
DR   InterPro; IPR026453; PGF_pre_PGF.
DR   NCBIfam; TIGR04275; beta_prop_Msarc; 4.
DR   NCBIfam; TIGR04213; PGF_pre_PGF; 1.
DR   PANTHER; PTHR36842; PROTEIN TOLB HOMOLOG; 1.
DR   PANTHER; PTHR36842:SF1; TOL-PAL SYSTEM PROTEIN TOLB; 1.
DR   Pfam; PF02368; Big_2; 8.
DR   SMART; SM00635; BID_2; 8.
DR   SUPFAM; SSF49373; Invasin/intimin cell-adhesion fragments; 8.
DR   SUPFAM; SSF50960; TolB, C-terminal domain; 1.
PE   4: Predicted;
FT   DOMAIN          356..436
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          446..526
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          533..613
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          623..703
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          713..793
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          800..880
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          884..964
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   DOMAIN          970..1050
FT                   /note="BIG2"
FT                   /evidence="ECO:0000259|SMART:SM00635"
FT   REGION          77..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1055..1085
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1237..1261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1066..1085
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1290 AA;  134111 MW;  F31A304743DCAADB CRC64;
     MTKHTHLALL CAVVIIGLLA SPAMAVEAAS GEEIYRPFVN AQERPDIDGD MIVWEDDRNG
     NKDIYFGTVD EFRNKPPLPT THVGERITSD DASQEKPSIS GDYIVWQDDR DGNWDIYLYQ
     RSTTTTTQLT NDTGDQWLPI VRGNHVAWYD DSNGRTNIVL YDIAAGAVKA TIDADAKTTI
     PDGATGFKPA LSEKYVAWIE EADERAWYYD IADETKMPVS GTGLRHSWPS LYGSQIAWEC
     YLDRTGIQDP EIYLMDLDNP SGGEQQITNA PNYQVSPALS GNIIAWEDMQ DGPRGIYMYD
     LATGGEEMSV FAPEDINDEQ LYPAVSGNTV AWQRGTGVNS NIYIFVYEPG AQVEPVVTTI
     TVTPTTATLA INETEAFTAT VLDQDGVTMT GIDVEWASSN ETVGTIDTTG TFTALAEGTA
     NVTATAENVT GEVTVTVTAG GPVDPAATRI EITPTTATLA INETVEFSAT VYDQFDAELP
     EAAVTWASSD ETVGTISAEG VFTAHAEGTA DVTATAGDAT ETATVTVSAE EPVLTGITVT
     PTTATLAIDE TEAFTATVLD QFGSAMTGID VAWASTNETV GTIDTTGTFT ALAEGTANVT
     ATAEGVTGEA TVTVTAGGPA EPAATRIEVA PLTTAATVNE TVNFSATVYD QFDAELPEAA
     VEWTSSNETV GTIDANGTFT ALAAGITAVT ATAGDAFASA VVTVNEGEPA EPVLESIRIT
     PPEATLAISD TQRFMMTARD QDGAVMTDVN VTWTSSDETV GTIDADGIFT ALTEGTATVT
     AAAENVTATA TITVNDEEPA LASIAVAPSA ITLGSGETAT FTATALDQFG TDMADVEITW
     TSSDETVGTI DADGVFSAVA DGMTTITAAA GNITGTAAAT VTTASSGVAV SPSAITLDIG
     GSQQFTATVY DLEGNVTTGV EVTWESSDEA VGTIDADGLF SPLADGTTTI TATAGNETGT
     ATVTVESSQV ATRIEIEPAT ATILPEETRA FTATVFDQRD NAMDWIKVTW SSSNPEVGTI
     DRAGLFGAFT EGSTDITASA GDAAGTAAVT VSATVVPEPT PGNGGSGGSG GDSSGGDSSP
     SFSAGIRENL RSGETFTFSE LTTTSVSSVN VTAASAIPKM MLTVKKAKAP SAAEPPTGDV
     YEYIEITPQW VGPNQIGNAT VFFSVPANWL ESHNVTAEDV VLMRYVNGAW QPLETEAIGE
     ENGRYNFRAT TPGFSVFAIA ASPVSVIASA EELNVTPEVT ETPEGTGTPE ETGNVTTEPT
     TAAPAATSAP LVYAPLLAPL AFLLWAKKKN
//