ID A0A2I0P4H8_9EURY Unreviewed; 255 AA.
AC A0A2I0P4H8;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=formylmethanofuran dehydrogenase {ECO:0000256|ARBA:ARBA00012692};
DE EC=1.2.7.12 {ECO:0000256|ARBA:ARBA00012692};
GN ORFNames=CVV31_13150 {ECO:0000313|EMBL:PKL61094.1};
OS Methanomicrobiales archaeon HGW-Methanomicrobiales-2.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanomicrobiales.
OX NCBI_TaxID=2013818 {ECO:0000313|EMBL:PKL61094.1, ECO:0000313|Proteomes:UP000233573};
RN [1] {ECO:0000313|EMBL:PKL61094.1, ECO:0000313|Proteomes:UP000233573}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HGW-Methanomicrobiales-2 {ECO:0000313|EMBL:PKL61094.1};
RX PubMed=28350393; DOI=10.1038/ismej.2017.39;
RA Hernsdorf A.W., Amano Y., Miyakawa K., Ise K., Suzuki Y., Anantharaman K.,
RA Probst A., Burstein D., Thomas B.C., Banfield J.F.;
RT "Potential for microbial H2 and metal transformations associated with novel
RT bacteria and archaea in deep terrestrial subsurface sediments.";
RL ISME J. 11:1915-1929(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + N-formylmethanofuran + 2 oxidized [2Fe-2S]-[ferredoxin]
CC = CO2 + H(+) + methanofuran + 2 reduced [2Fe-2S]-[ferredoxin];
CC Xref=Rhea:RHEA:19841, Rhea:RHEA-COMP:10000, Rhea:RHEA-COMP:10001,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC ChEBI:CHEBI:33737, ChEBI:CHEBI:33738, ChEBI:CHEBI:57727,
CC ChEBI:CHEBI:58151; EC=1.2.7.12;
CC Evidence={ECO:0000256|ARBA:ARBA00000989};
CC -!- PATHWAY: One-carbon metabolism; methanogenesis from CO(2); 5,10-
CC methenyl-5,6,7,8-tetrahydromethanopterin from CO(2): step 1/3.
CC {ECO:0000256|ARBA:ARBA00004830}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKL61094.1}.
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DR EMBL; PGYL01000048; PKL61094.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0P4H8; -.
DR UniPathway; UPA00640; UER00692.
DR Proteomes; UP000233573; Unassembled WGS sequence.
DR GO; GO:0018493; F:formylmethanofuran dehydrogenase activity; IEA:UniProtKB-EC.
DR GO; GO:0046914; F:transition metal ion binding; IEA:InterPro.
DR GO; GO:0019386; P:methanogenesis, from carbon dioxide; IEA:UniProtKB-UniPathway.
DR Gene3D; 2.160.20.60; Glutamate synthase, alpha subunit, C-terminal domain; 2.
DR InterPro; IPR017550; Formylmethanofuran_DH_suC.
DR InterPro; IPR002489; Glu_synth_asu_C.
DR InterPro; IPR036485; Glu_synth_asu_C_sf.
DR NCBIfam; TIGR03122; one_C_dehyd_C; 1.
DR PANTHER; PTHR39673; TUNGSTEN FORMYLMETHANOFURAN DEHYDROGENASE, SUBUNIT C (FWDC); 1.
DR PANTHER; PTHR39673:SF7; TUNGSTEN-CONTAINING FORMYLMETHANOFURAN DEHYDROGENASE 2 SUBUNIT C; 1.
DR Pfam; PF01493; GXGXG; 1.
DR SUPFAM; SSF69336; Alpha subunit of glutamate synthase, C-terminal domain; 1.
PE 4: Predicted;
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 96..225
FT /note="Glutamate synthase alpha subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF01493"
SQ SEQUENCE 255 AA; 26976 MW; ECCC713C438F008C CRC64;
MKVTLAMKPA AKSFIPIEAE SIVPKNFLAG ADLLVWRGNR ELRLDEVFSV SIEGDASRAE
DVEVVLSGDT FRLKRVGEYM NGGKITVLGG IGMHCGNFMS GGTIEVHGNA DGWLGREMAG
GTILCRGDAA DYCASGYRGG RKGMTGGTVE VFGRAGDFLA ESIAGGTVTV HGDAGDMAGV
EMHGGTLIVH GDCRRPGANM KGGSCYVYGT AQAMLPTFKK NETVQHEGRT LIHFTGDIAN
RGKGNLFVKD YEYLG
//
