ID A0A2I0R697_9FLAO Unreviewed; 1298 AA.
AC A0A2I0R697;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE RecName: Full=Guanylate cyclase domain-containing protein {ECO:0000259|PROSITE:PS50125};
GN ORFNames=CW751_01795 {ECO:0000313|EMBL:PKR82095.1};
OS Brumimicrobium salinarum.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Crocinitomicaceae; Brumimicrobium.
OX NCBI_TaxID=2058658 {ECO:0000313|EMBL:PKR82095.1, ECO:0000313|Proteomes:UP000236654};
RN [1] {ECO:0000313|EMBL:PKR82095.1, ECO:0000313|Proteomes:UP000236654}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LHR20 {ECO:0000313|EMBL:PKR82095.1,
RC ECO:0000313|Proteomes:UP000236654};
RA Do Z.-J., Luo H.-R.;
RT "The draft genome sequence of Brumimicrobium saltpan LHR20.";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the adenylyl cyclase class-4/guanylyl cyclase
CC family. {ECO:0000256|RuleBase:RU000405}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKR82095.1}.
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DR EMBL; PJNI01000001; PKR82095.1; -; Genomic_DNA.
DR OrthoDB; 358279at2; -.
DR Proteomes; UP000236654; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004016; F:adenylate cyclase activity; IEA:UniProt.
DR GO; GO:0009190; P:cyclic nucleotide biosynthetic process; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR CDD; cd00077; HDc; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR018297; A/G_cyclase_CS.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR011110; Reg_prop.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR011123; Y_Y_Y.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF13; SOLUBLE GUANYLATE CYCLASE GCY-35-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF01966; HD; 1.
DR Pfam; PF07494; Reg_prop; 3.
DR Pfam; PF07495; Y_Y_Y; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00471; HDc; 1.
DR SUPFAM; SSF63829; Calcium-dependent phosphotriesterase; 3.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS00452; GUANYLATE_CYCLASE_1; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils}; Lyase {ECO:0000256|RuleBase:RU000405};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000236654};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 793..811
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 895..1026
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT COILED 829..867
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1298 AA; 150245 MW; DA3DA27EEBE0830C CRC64;
MKYFFIKTFT LYVVIVLSQF SLFGQDHIQF KNYTINDGLS QSSVTSIVQD QLGALWLGTQ
DGINRFNGKN FQVFNSDQYH KVSNEFIHTA FKDRNNNLWF GTYNGLTKYN PRTVQFSAYK
FDNKRRLEIH AITEDRNGNL WIGTAYGRIF KFNTKTANFE LIDDQIFDSK IIDIRNQNDQ
LIFVSEFNGV LMTDYNFTNT IIVKPEVENT DDFLITGLIN SPEHDIVITT NRGVFYFDSN
LHTFKILNDL FAPLADYKII DALYLSRDRL FVASENNGLF QVTRQENDSI NVLNYTADIF
QKGALISNKL NGLFIDNQGS IWITSQRGLS SFNPTFIGFK GVSTSANLQK GLPSQNIWGF
AESEDERYLY IAADHGISRF DRKTHIYQHY YLKGELINDA TTLSIQLIDA NTLLLGTIEG
LFELNINPKD ETDYFFTKFE HEEHAQRGFD LTYTIVPYLG ESQYLIGTKA GVVHFDYADK
SFNYLFHNPE ESNTIGTGPC RLIFKDSTDY YVSPSSGGLY KIIDDAGKLS ATSNHDFSIL
KTITNDYFSD VFIENNTQYW FGTMGDGLIH FNRDTKTTKK YTKSDGLPNN VVYGVESTQN
DPMYLWLSTN KGVSAFNIQT KAFHNFTEKD GLMSNELNLG ASFVSKAKEV YFGGIQGFNY
IQPEQAFEIN RNIHVYFSGI EVENEPVFPE KDGILSQSIA YTDKIKLPYT QRSLKLNFFA
NDLTHPERIE YKYVMSGDDQ VEEELGYSNE LRFTSIAPGN YELKIYARIS NGNWNKYPAR
LIITVERPFW LKWWFYAIII CFIALVVLIR VRTRMDKERR LQVRLEMKIA ERTRELRKKN
EQIQQQKERL LKQTKELESE RVKTERLLNN ILPKETASQL KKDGRSAARA FNKVSIMFTD
FVGFSKIAEE MSAKDLVSIL DMHFRQFDRI IEKNDLEKIK TIGDAYMCAG GVPIRNKTNP
IHTTLAAVQI KDYMRKHKEE QLQKNEPYWK LRIGINTGPV SAGVIGTKRY AYDVWGNTVN
RAQRMEQLCE PGKIAITQDT FDHIEPYFIC RKKGKIKAKS GVKILMFEVV SIKPELSIDG
LGVEPNESFH KLVNLHHFSK INYYKAERFI LSKLKKELSP KLHYHSFDHS KDVTRQAERI
AIGEGITDED LFLLKSAASY HDAGFVEQYD KNEPIGARMA AEILPKFGYT EAHIQRIKEL
IYVTQVPHKP KNNLEEIICD ADLDYLGRDD FHEIADRLRR ELREHGKIDS DRKWDEMQVK
FLTQHRYFTQ TSIQTRLKKK KQNLAEIKER LAQDDYID
//
