ID   A0A2I0SAT6_9ACTN        Unreviewed;       844 AA.
AC   A0A2I0SAT6;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=Beta-ketoacyl synthase {ECO:0000313|EMBL:PKT67048.1};
DE   Flags: Fragment;
GN   ORFNames=CW362_42615 {ECO:0000313|EMBL:PKT67048.1};
OS   Streptomyces populi.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2058924 {ECO:0000313|EMBL:PKT67048.1, ECO:0000313|Proteomes:UP000236178};
RN   [1] {ECO:0000313|EMBL:PKT67048.1, ECO:0000313|Proteomes:UP000236178}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A249 {ECO:0000313|EMBL:PKT67048.1,
RC   ECO:0000313|Proteomes:UP000236178};
RA   Wang Z.;
RT   "Streptomyces populusis sp. nov., a novel endophytic actinobacterium
RT   isolated from stems of Populus adenopoda Maxim.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC         Evidence={ECO:0000256|ARBA:ARBA00001957};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKT67048.1}.
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DR   EMBL; PJOS01000238; PKT67048.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2I0SAT6; -.
DR   Proteomes; UP000236178; Unassembled WGS sequence.
DR   GO; GO:0016740; F:transferase activity; IEA:InterPro.
DR   Gene3D; 3.30.70.3290; -; 1.
DR   Gene3D; 3.40.50.11460; -; 1.
DR   Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   InterPro; IPR001227; Ac_transferase_dom_sf.
DR   InterPro; IPR014043; Acyl_transferase.
DR   InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR   InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR049551; PKS_DH_C.
DR   InterPro; IPR049552; PKS_DH_N.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR   Pfam; PF00698; Acyl_transf_1; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00827; PKS_AT; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000236178}.
FT   DOMAIN          104..400
FT                   /note="Malonyl-CoA:ACP transacylase (MAT)"
FT                   /evidence="ECO:0000259|SMART:SM00827"
FT   DOMAIN          464..627
FT                   /note="Polyketide synthase dehydratase"
FT                   /evidence="ECO:0000259|SMART:SM00826"
FT   REGION          578..600
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        583..599
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:PKT67048.1"
FT   NON_TER         844
FT                   /evidence="ECO:0000313|EMBL:PKT67048.1"
SQ   SEQUENCE   844 AA;  89610 MW;  A6D5A867558AF9C8 CRC64;
     EQTPDVLRTP GLAGTEPWLL SAKSADALRE QARRLAALVR DDTTASPAEI GHALATTRSC
     FEHRAAVVAT TREEFLTGLA ALADDTTAAG VVRGRARQGK VAFVFPGQGS QWHGMAAELL
     ETSPVFAQRM TECAQALAPH TDWDLLEVVR GTDSGWLTRV DMVQPALFAV MVSLAQLWHS
     HGVRPAAVIG HSQGEIAAAC VAGALSLKDA AKVVALRSRA LIALAGKGGM LSVALSADDL
     APLLRRWQGS LWLAAVNGPQ ASVVSGDPAA LSELETHCRA QKVRTRTIPV DYASHSAHVE
     EIRERLLAEL ADVTPRRARI TFCSTVTGAP LDTTGLDADY WYRNLRGTVL LETATRTLLE
     QGYRTFIEAS PHPGLTIALQ DTIAEAAADA VALETLRRQD GGPHRFLTSL AQAHAHGVQV
     EWDYAGAPRT ALPTYAFQRE RHWLDAPAPA AADAGSLGVG PLGHPLLKAA LPAATGGELV
     LTGRLSARAQ PWLPDHQVAA RPVVPGTAVV EMALAAGAQA GCDTVDELTL RRPLVLPEDG
     GLQLQLRITG PEPDLTRRAE LYARPDDAPA WTHHASAVLA PSPPAPDDGP GPLAAWPPPG
     AQPVDTTGFY DALAERGYHY GPAFRALRGA WRSGEELFAE VALDAAHRTD AASYLLHPAL
     LDAALHVIAV HDTTRLRLPF SWNGVRLRAT AATSLRVRIT PRTADSYAVE LADTQGTVGS
     VEDLTLRTVD PRQLEAGHAG HALLRLDWTP LALPAAPAAP QTLAVLGPRP LLAHTPHYPD
     LAAVPQDVTT VVADLTEPLP GPRPTAHRAL ALLQAWLADE RFGDARLVLL VGPAEDPAHA
     PVWG
//