ID A0A2I0UBK0_LIMLA Unreviewed; 372 AA.
AC A0A2I0UBK0;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Serine incorporator 1 {ECO:0000256|ARBA:ARBA00040945};
DE AltName: Full=Tumor differentially expressed protein 2 {ECO:0000256|ARBA:ARBA00041691};
GN ORFNames=llap_6256 {ECO:0000313|EMBL:PKU43447.1};
OS Limosa lapponica baueri.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Scolopacidae; Limosa.
OX NCBI_TaxID=1758121 {ECO:0000313|EMBL:PKU43447.1, ECO:0000313|Proteomes:UP000233556};
RN [1] {ECO:0000313|Proteomes:UP000233556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lima N.C., Parody-Merino A.M., Battley P.F., Fidler A.E., Prosdocimi F.;
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000233556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lima N.C.B., Parody-Merino A.M., Battley P.F., Fidler A.E., Prosdocimi F.;
RT "Genome sequence of the Bar-tailed Godwit (Limosa lapponica baueri).";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Enhances the incorporation of serine into phosphatidylserine
CC and sphingolipids. {ECO:0000256|ARBA:ARBA00037552}.
CC -!- SUBUNIT: Interacts with SPTLC1. {ECO:0000256|ARBA:ARBA00011492}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the TDE1 family.
CC {ECO:0000256|ARBA:ARBA00006665}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ505903; PKU43447.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0UBK0; -.
DR Proteomes; UP000233556; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR InterPro; IPR005016; TDE1/TMS.
DR PANTHER; PTHR10383; SERINE INCORPORATOR; 1.
DR PANTHER; PTHR10383:SF15; SERINE INCORPORATOR 1; 1.
DR Pfam; PF03348; Serinc; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000233556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 157..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 306..326
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 346..366
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 372 AA; 41699 MW; 1069C94ECF0D3DF3 CRC64;
MVTKVFLLQV KVCEAVFGIP DNPAMGPLQT WCPLKELMEV ACADHGTDSV ACVMLIPGME
EQLKKIPGFC DGGMGTTIPG VHGHVNCDVL VGYKAVYRVC FGMAMFFLLF SLLMIKVKSS
NDPRAAVHNG FWFFKFATAL AISVGAFFIP EGPFTTVWFY VGMAGAFCFI LIQLVLLIDF
AHSWNESWVE KMEEGNSRCW YADRRCNPSL LSIIGYNSTT IPTQGQVVQW WDAQGIVGLV
LFLLCVLYSS IRTSNNSQVN KLMLTSDEST LIEDGMPRSD GSLDDGDDVH RAIDNERDGV
TYSYSFFHFM LFLASLYIMM TLTNWYSPDS SYETMTSKWP SVWVKISSSW IGIVLYVWTL
VAPLVLTNRD FD
//
