ID A0A2I0UCS3_LIMLA Unreviewed; 520 AA.
AC A0A2I0UCS3;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 22-FEB-2023, entry version 17.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN ORFNames=llap_5868 {ECO:0000313|EMBL:PKU43845.1};
OS Limosa lapponica baueri.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Charadriiformes; Scolopacidae; Limosa.
OX NCBI_TaxID=1758121 {ECO:0000313|EMBL:PKU43845.1, ECO:0000313|Proteomes:UP000233556};
RN [1] {ECO:0000313|Proteomes:UP000233556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lima N.C., Parody-Merino A.M., Battley P.F., Fidler A.E., Prosdocimi F.;
RL Submitted (NOV-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Proteomes:UP000233556}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Lima N.C.B., Parody-Merino A.M., Battley P.F., Fidler A.E., Prosdocimi F.;
RT "Genome sequence of the Bar-tailed Godwit (Limosa lapponica baueri).";
RL Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family.
CC {ECO:0000256|RuleBase:RU000630}.
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DR EMBL; KZ505868; PKU43845.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I0UCS3; -.
DR Proteomes; UP000233556; Unassembled WGS sequence.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR CDD; cd14686; bZIP; 1.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF60; GAP JUNCTION ALPHA-9 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000233556};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 20..40
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 211..231
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..76
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 167..233
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 321..359
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..520
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..142
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 338..359
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 520 AA; 58342 MW; 759209D608D05435 CRC64;
MGDWNFLGGI LEEVHIHSTI IGKIWLTILF IFRMLVLGVA TEDVWNDEQS EFICNTEQPG
CRNVCYDEAF PISLIRYWVL QVIFVSSPSL VYMGHALYRL RALEKERQKK KAQVRVELES
TELEMTENRK RLERELRQLD QRKLNKAPLR GSLLCTYVIH IFTRSAVEVG FMIGQYLLYG
FHLDPLYKCQ RDPCPNTVDC FVSRPTEKTV FILFMQSIAT VSLLLNILEI IHLGFRKIKM
GLCGQNKTKD DPDNFYVNKS KKYSMIPHSS LGISTTPQKN APSALSGYTF LTEKQTDIAV
YPVLNSPPVF QSVQNNCAES SSNYTHHNWE NKSPKKRPAT NALDNQTQNT STNNNEGLFG
KLGTEVCDAQ KEAQKKHFLV GTQNADTASS TCLRSFAEMP SQTSLQPDTT FPITGFRRQH
GISSAWNCST MVESAGSSTN SLPKNSNGRQ SSFSANQAQP PYTTDVKNSS RPDTPGSTGG
VSSESKHSRN CDSPKPFSLS RRLSLSSNAS SRRAPTDLQI
//
