ID A0A2I0WVB6_9ASPA Unreviewed; 1908 AA.
AC A0A2I0WVB6;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=Mediator of RNA polymerase II transcription subunit 13 {ECO:0000256|ARBA:ARBA00019618, ECO:0000256|RuleBase:RU364134};
GN Name=MED13 {ECO:0000313|EMBL:PKU79573.1};
GN ORFNames=MA16_Dca000919 {ECO:0000313|EMBL:PKU79573.1};
OS Dendrobium catenatum.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Asparagales; Orchidaceae;
OC Epidendroideae; Malaxideae; Dendrobiinae; Dendrobium.
OX NCBI_TaxID=906689 {ECO:0000313|EMBL:PKU79573.1, ECO:0000313|Proteomes:UP000233837};
RN [1] {ECO:0000313|EMBL:PKU79573.1, ECO:0000313|Proteomes:UP000233837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=The whole plant {ECO:0000313|EMBL:PKU79573.1};
RX PubMed=26754549; DOI=10.1038/srep19029;
RA Zhang G.Q., Xu Q., Bian C., Tsai W.C., Yeh C.M., Liu K.W., Yoshida K.,
RA Zhang L.S., Chang S.B., Chen F., Shi Y., Su Y.Y., Zhang Y.Q., Chen L.J.,
RA Yin Y., Lin M., Huang H., Deng H., Wang Z.W., Zhu S.L., Zhao X., Deng C.,
RA Niu S.C., Huang J., Wang M., Liu G.H., Yang H.J., Xiao X.J., Hsiao Y.Y.,
RA Wu W.L., Chen Y.Y., Mitsuda N., Ohme-Takagi M., Luo Y.B., Van de Peer Y.,
RA Liu Z.J.;
RT "The Dendrobium catenatum Lindl. genome sequence provides insights into
RT polysaccharide synthase, floral development and adaptive evolution.";
RL Sci. Rep. 6:19029-19029(2016).
RN [2] {ECO:0000313|EMBL:PKU79573.1, ECO:0000313|Proteomes:UP000233837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=The whole plant {ECO:0000313|EMBL:PKU79573.1};
RX PubMed=28902843; DOI=10.1038/nature23897;
RA Zhang G.Q., Liu K.W., Li Z., Lohaus R., Hsiao Y.Y., Niu S.C., Wang J.Y.,
RA Lin Y.C., Xu Q., Chen L.J., Yoshida K., Fujiwara S., Wang Z.W., Zhang Y.Q.,
RA Mitsuda N., Wang M., Liu G.H., Pecoraro L., Huang H.X., Xiao X.J., Lin M.,
RA Wu X.Y., Wu W.L., Chen Y.Y., Chang S.B., Sakamoto S., Ohme-Takagi M.,
RA Yagi M., Zeng S.J., Shen C.Y., Yeh C.M., Luo Y.B., Tsai W.C.,
RA Van de Peer Y., Liu Z.J.;
RT "The Apostasia genome and the evolution of orchids.";
RL Nature 549:379-383(2017).
CC -!- FUNCTION: Component of the Mediator complex, a coactivator involved in
CC regulated transcription of nearly all RNA polymerase II-dependent
CC genes. Mediator functions as a bridge to convey information from gene-
CC specific regulatory proteins to the basal RNA polymerase II
CC transcription machinery. Mediator is recruited to promoters by direct
CC interactions with regulatory proteins and serves as a scaffold for the
CC assembly of a functional preinitiation complex with RNA polymerase II
CC and the general transcription factors. {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBUNIT: Component of the Mediator complex.
CC {ECO:0000256|RuleBase:RU364134}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU364134}.
CC -!- SIMILARITY: Belongs to the Mediator complex subunit 13 family.
CC {ECO:0000256|ARBA:ARBA00009354, ECO:0000256|RuleBase:RU364134}.
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DR EMBL; KZ502442; PKU79573.1; -; Genomic_DNA.
DR STRING; 906689.A0A2I0WVB6; -.
DR Proteomes; UP000233837; Unassembled WGS sequence.
DR GO; GO:0016592; C:mediator complex; IEA:InterPro.
DR GO; GO:0003712; F:transcription coregulator activity; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR009401; Med13_C.
DR InterPro; IPR021643; Mediator_Med13_N.
DR InterPro; IPR041285; MID_MedPIWI.
DR PANTHER; PTHR48249; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR PANTHER; PTHR48249:SF3; MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13; 1.
DR Pfam; PF06333; Med13_C; 1.
DR Pfam; PF11597; Med13_N; 1.
DR Pfam; PF18296; MID_MedPIWI; 1.
PE 3: Inferred from homology;
KW Activator {ECO:0000256|RuleBase:RU364134};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU364134};
KW Reference proteome {ECO:0000313|Proteomes:UP000233837};
KW Repressor {ECO:0000256|ARBA:ARBA00022491, ECO:0000256|RuleBase:RU364134};
KW Transcription {ECO:0000256|ARBA:ARBA00023163,
KW ECO:0000256|RuleBase:RU364134};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW ECO:0000256|RuleBase:RU364134}.
FT DOMAIN 39..289
FT /note="Mediator complex subunit Med13 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11597"
FT DOMAIN 1083..1318
FT /note="MID"
FT /evidence="ECO:0000259|Pfam:PF18296"
FT DOMAIN 1478..1879
FT /note="Mediator complex subunit Med13 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF06333"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 271..300
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1908 AA; 206745 MW; 83B978852E596D8A CRC64;
MSHCSCCSPH PRSTPATARP LSQQKDAATF SVISAHLRLQ NDGFLSTWTN SFVGPWDPSQ
GVHNPDEKIK LWLFIPGRHS SLVEPAQAAV SKLRVVGRGV WLAPGDSEEV AVALSQAFRN
SIERAFRGLS YVRFGDVFAK SHSASSGKSF RKAHPTCEFI FAATEEAIYI HVIISAKHLR
NLNDDDIERV LKRSSSNSVR KGLPVFVSPN GMRGRLTGCC PTDLVKQVYT SKLKANNESA
HVLPSISRST GYQLRGQNCF VEVTLGCPST SNKDAQERKR NQEITSVTPK SEEPCLASSG
KNQQFDPFPI LERTFIYPAE SVLVPVLHRA FARSSLKRFF LKSWTGTSFH ELWPFWNFPS
SSQFLRWQSG LSSNDQFDND GKKMVSKRLR SSVTDVFGQA ATVASVTAQN AAKSEFSVVD
ANNSAIGGSA NVQVGSSWDW DDDDRGIGID IQSLLAEFGD FGDFFENDVL DFGEPPGTAE
SQVIVFPSVD CGDISGSPCT AGIDSPDQRI SAVGLTSFEN YNQPSSTFSE DTDGTKDAKS
SVTITHSLES SNGKFDNLMK AEAMLTFSPE YAAVEICSSE FSISIFRNPY LPGSKKVETS
LVPSCAHVYG ATPPSPSVSD MEESFEKSSK LKPGIGLYAV SSGQLGKLYT LVKGVPKKID
SKLFNDVMPS HKGQKPSSLS VMKSSSGTSA LQINNDSTFE AGHFLLSLET LLATEIECII
FQVAMCRIRH TLLSFNSRRP IGLNKLTGDA MLDLISYDTN SLPDVIPNKH EAKKKDMLPV
RIAGDVHIGM LDAPLTSSVG VWRPVGVPKG TKPSNTCLPQ NSPSLPHNLS NEETFGFRGQ
RQPLQELLDA IGLLVQQSAS LVDVSLDMDD VDGSYSWLAL EEQQRRGFSC GPSMVHAGCG
GIFASCHYVD IAGIELIDPL SANVQVSNVI SLLQSDIKLG LKSAFPSSEG PLSLTEWCRG
RHQLGDSGAS GDGHPFQYTI GEVKDPLSTV SLGGEPISPP QSGCVSSCIR DGVRIDDSTQ
RRSNQDICGS ESDAQKFSSR FKPTLAALSL PALLVGYDDW LKTSVNCLQL WEKAPLEPYA
SPKPVSYFAL CPDIDLLTSA GTDFFQQLGT VYEACKLGSH TLQINGGLME SSSGKLSSSG
LLLVNCPQEL KVASSNMLSI SSITDYFVAL SKCWNVKGYL NSVKKVLKGL KLAANPSPNH
KERNVGPCMV VYVVCPFPEP TAVLQTVIEC SAALGSGVLA PDKDRQSLLY NQVAKSLISS
AAVDEASASN VVMLSGFRIP KLVLQIVTVD CLLRLNRPSK ELGIFKEIAF TVYNKIRRIP
RTASGADIFQ SSAISGRPQS TLMHVTSPIP GIWKDCLAPR ISGPALTREA ELDSSLRPVP
WDNSWQTRIG GLSSDPHRSV ELCLQDDPRY VFEPLFVLAE PGSVEHAIFP AVLYNNMPEC
SSSKSSIEDN SSIYVQSSST GGAAEIGKGS SHDGSEHDNR AANLHCSYGW TEDWRWLICV
WTDSRGELLD CSIFPFGGIS SRQDTKVLQN LFVQVLHHSC QILSSSSLDS GSRLRDIIIT
RIGCYFELEC QEWQKAIYSV GGNDVKKWPV QLRRTAPDGV LNNSGASLEQ QEISLIQERA
LPSSPSPLYN PHAKPSFIKG GLGQTNAKKQ ILAGQAGLDS SRGLLQLARS ISLVSVSMDH
TLHLILPSDL SSSGVGQSNS SSSGISNYLE GFSPVKSLGS MPGSYLLIPS PSMRFLPPSP
LQLPTCLTSE SPPLAHLLHS KGSAIPQSTG FVVSKSIPNP RKDFVEPIKE DCPSILSVGL
VDHYGGQEKL AVAVGRGGGS AMAAKQGRSL GPEPVSRDYE VEANLVLESV AAELHSLSWM
TVSPLYLERR SALPFHCDIL LRLRRLLHYA DKEFSKASEQ LEPADTDL
//
