ID A0A2I1G520_9GLOM Unreviewed; 525 AA.
AC A0A2I1G520;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE RecName: Full=Eukaryotic translation initiation factor 2A {ECO:0000256|ARBA:ARBA00013819, ECO:0000256|PIRNR:PIRNR017222};
DE Short=eIF-2A {ECO:0000256|PIRNR:PIRNR017222};
GN ORFNames=RhiirA4_501730 {ECO:0000313|EMBL:PKY41723.1};
OS Rhizophagus irregularis.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=588596 {ECO:0000313|EMBL:PKY41723.1, ECO:0000313|Proteomes:UP000234323};
RN [1] {ECO:0000313|EMBL:PKY41723.1, ECO:0000313|Proteomes:UP000234323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:PKY41723.1,
RC ECO:0000313|Proteomes:UP000234323};
RA Ropars J., Sedzielewska K., Noel J., Charron P., Farinelli L., Marton T.,
RA Kruger M., Pelin A., Brachmann A., Corradi N.;
RT "Genome analyses suggest a sexual origin of heterokaryosis in a supposedly
RT ancient asexual fungus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Functions in the early steps of protein synthesis of a small
CC number of specific mRNAs. Acts by directing the binding of methionyl-
CC tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it
CC binds methionyl-tRNAi to 40S subunits in a codon-dependent manner,
CC whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a
CC GTP-dependent manner. {ECO:0000256|PIRNR:PIRNR017222}.
CC -!- SIMILARITY: Belongs to the WD repeat EIF2A family.
CC {ECO:0000256|ARBA:ARBA00009573, ECO:0000256|PIRNR:PIRNR017222}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKY41723.1}.
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DR EMBL; LLXI01000163; PKY41723.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I1G520; -.
DR VEuPathDB; FungiDB:FUN_023628; -.
DR VEuPathDB; FungiDB:FUN_023629; -.
DR VEuPathDB; FungiDB:GLOIN_2v1742692; -.
DR VEuPathDB; FungiDB:RhiirA1_410635; -.
DR OrthoDB; 22264at2759; -.
DR Proteomes; UP000234323; Unassembled WGS sequence.
DR GO; GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-UniRule.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR InterPro; IPR011387; TIF2A.
DR InterPro; IPR013979; TIF_beta_prop-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR13227; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR PANTHER; PTHR13227:SF0; EUKARYOTIC TRANSLATION INITIATION FACTOR 2A; 1.
DR Pfam; PF08662; eIF2A; 1.
DR PIRSF; PIRSF017222; eIF2A; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Initiation factor {ECO:0000256|ARBA:ARBA00022540,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|PIRNR:PIRNR017222};
KW Reference proteome {ECO:0000313|Proteomes:UP000234323};
KW Signal {ECO:0000256|SAM:SignalP};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845,
KW ECO:0000256|PIRNR:PIRNR017222}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..525
FT /note="Eukaryotic translation initiation factor 2A"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5014140474"
FT DOMAIN 193..388
FT /note="Translation initiation factor beta propellor-like"
FT /evidence="ECO:0000259|Pfam:PF08662"
FT REGION 412..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 460..481
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 59351 MW; 6EE6AFE1B52E81EE CRC64;
MCVFFILFLQ ITFNSPGSNV KTFQYSKDGE YLGCALPESV KIFDAETAQL VSEIPKKQIV
EIGFSPKGTY ISTWERPVKS ADGSVHKNLI IWEVITGKQL ISFTQKSQNN WNVQWTEDEM
YFSRMVTGEV HFYDSKRLDE GITNKLRLEN IGDFSISPGK SASIAVFIPE KNAAPAIVRI
YSIANFKVPL AQKTFYKADK IQMKWNDSGT NLLVLTQTDV DKTNKSYYGE TNLFLLSVTG
SYDCRVMLDK EGPIHDVTWG PSSKEFVVIY GYMPAKATLF DHRANPIHEF GTGIFRNTVR
FNPQGRYILS LSGFGNLKGE MDIWDRKTLK KIAEIEAPNS SESSWSPDGI YIMTAILSPR
LRVDNGYKIW HYTGSLVHNQ NIDELLQIQW RPTSVEFYPL ADLPPAPEIT KGLASPTKTA
PATKAGAYLP PHARARGAPS AVKVHENGAK PVGSKNKKKP KKKKEEEVAK ETAKDKKIRN
LTKKLRQIDE LKERQKNGDK LEQTQIKKIE TEATLRKELD RLNLQ
//
