ID A0A2I1GA76_9GLOM Unreviewed; 787 AA.
AC A0A2I1GA76;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Class E vacuolar protein-sorting machinery protein HSE1 {ECO:0000256|ARBA:ARBA00017923};
DE AltName: Full=Class E vacuolar protein-sorting machinery protein hse1 {ECO:0000256|ARBA:ARBA00018978};
GN ORFNames=RhiirA4_457519 {ECO:0000313|EMBL:PKY43523.1};
OS Rhizophagus irregularis.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=588596 {ECO:0000313|EMBL:PKY43523.1, ECO:0000313|Proteomes:UP000234323};
RN [1] {ECO:0000313|EMBL:PKY43523.1, ECO:0000313|Proteomes:UP000234323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:PKY43523.1,
RC ECO:0000313|Proteomes:UP000234323};
RA Ropars J., Sedzielewska K., Noel J., Charron P., Farinelli L., Marton T.,
RA Kruger M., Pelin A., Brachmann A., Corradi N.;
RT "Genome analyses suggest a sexual origin of heterokaryosis in a supposedly
RT ancient asexual fungus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the ESCRT-0 complex which is the sorting
CC receptor for ubiquitinated cargo proteins at the multivesicular body
CC (MVB). {ECO:0000256|ARBA:ARBA00002654}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the STAM family.
CC {ECO:0000256|ARBA:ARBA00009666}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKY43523.1}.
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DR EMBL; LLXI01000259; PKY43523.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I1GA76; -.
DR VEuPathDB; FungiDB:FUN_004449; -.
DR VEuPathDB; FungiDB:GLOIN_2v1476395; -.
DR VEuPathDB; FungiDB:RhiirA1_387465; -.
DR OrthoDB; 620063at2759; -.
DR Proteomes; UP000234323; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR GO; GO:0043130; F:ubiquitin binding; IEA:InterPro.
DR GO; GO:0016197; P:endosomal transport; IEA:UniProt.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProt.
DR GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR CDD; cd21386; GAT_Hse1; 1.
DR CDD; cd11805; SH3_GRB2_like_C; 1.
DR CDD; cd16978; VHS_HSE1; 1.
DR Gene3D; 1.20.5.1940; -; 1.
DR Gene3D; 1.25.40.90; -; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR008942; ENTH_VHS.
DR InterPro; IPR004152; GAT_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR002014; VHS_dom.
DR PANTHER; PTHR45929; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR PANTHER; PTHR45929:SF3; JAK PATHWAY SIGNAL TRANSDUCTION ADAPTOR MOLECULE; 1.
DR Pfam; PF03127; GAT; 1.
DR Pfam; PF00018; SH3_1; 1.
DR Pfam; PF00790; VHS; 1.
DR PRINTS; PR00499; P67PHOX.
DR PRINTS; PR00452; SH3DOMAIN.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00288; VHS; 1.
DR SUPFAM; SSF48464; ENTH/VHS domain; 1.
DR SUPFAM; SSF89009; GAT-like domain; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50179; VHS; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000234323};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 15..145
FT /note="VHS"
FT /evidence="ECO:0000259|PROSITE:PS50179"
FT DOMAIN 217..276
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 179..216
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 459..539
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 577..733
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..787
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 787 AA; 89406 MW; 04F7F7DDBA05AACD CRC64;
MFKNPNQFED DVIAATNETL TKENWELITT LCEKVEQGGE QGARDCVAAI QKRLLHRNPN
VQGYALTLSN SLVKMCSINV HKEISSRAFT QTLTRILQDK STHGTVKDRI LDLIQEWSNE
FRSDDTLSLM EETMNNLRSQ GFHFPSPEKP KKELSEYELE KQKKEEEEQV QLAMAISLSE
RSGSRNTTTA SFTTTSTTTI ATPSEPASQN KDLPHTPSVS KVKALYDFVP TESGELGFSR
GDVITVLDSV YKDWWRGELH GKTGIFPVNY VEKLPEPTAA DIAREAELEA AIFAEGRNID
QLLEMLAGLD PTRDSVTENE VIQNLYNNTL PVRPKLMKLI EKYSQKKDDL IALNKKFTEA
TKTYDRLMAE SLKKYDAYIN PTPAPPQFNF PPVTTGYTPA QNYPVGYDSA AAYGYYNPQQ
HFKQIQQPAY QAPHHPQQYP PQIQQEVVGH LNAYQQSQFQ PQQDNGISQQ QQPAYQATQH
PQQYPPQVQQ EVVGQHGAYQ QPQAQSQAQY PPAQPQKDNE KHQQQPTYQT PHPQQYTSQI
QQDAMGQFSA YQANQQQNQQ SSNYSTQQVP LYPPQVQQDA STYQQLHQQQ EAQQSQQQIP
PNFSTSDNNM LNPTIQPQQP QQPQQQQPQQ LQQQQPQQLQ QQQPQQLQQQ QPQQLQQQHQ
QQQQPYSQPP IQYLSSDGSG GYQSQPSTSN TQPPNSTNSN NMYSSNNDIT QYPPPTTDQQ
LPQIHPSSQQ PISLAQISQH IQAQSNFPPT QQQQQYQQQN PYFNQPDELQ VPQGASASYS
TPVNVNM
//
