ID A0A2I1GLZ7_9GLOM Unreviewed; 450 AA.
AC A0A2I1GLZ7;
DT 28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT 28-FEB-2018, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Nuclear membrane protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=RhiirA4_444965 {ECO:0000313|EMBL:PKY47653.1};
OS Rhizophagus irregularis.
OC Eukaryota; Fungi; Fungi incertae sedis; Mucoromycota; Glomeromycotina;
OC Glomeromycetes; Glomerales; Glomeraceae; Rhizophagus.
OX NCBI_TaxID=588596 {ECO:0000313|EMBL:PKY47653.1, ECO:0000313|Proteomes:UP000234323};
RN [1] {ECO:0000313|EMBL:PKY47653.1, ECO:0000313|Proteomes:UP000234323}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=A4 {ECO:0000313|EMBL:PKY47653.1,
RC ECO:0000313|Proteomes:UP000234323};
RA Ropars J., Sedzielewska K., Noel J., Charron P., Farinelli L., Marton T.,
RA Kruger M., Pelin A., Brachmann A., Corradi N.;
RT "Genome analyses suggest a sexual origin of heterokaryosis in a supposedly
RT ancient asexual fungus.";
RL Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Required for nuclear membrane fusion during karyogamy.
CC {ECO:0000256|ARBA:ARBA00003389, ECO:0000256|RuleBase:RU368082}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|RuleBase:RU368082}. Nucleus membrane
CC {ECO:0000256|RuleBase:RU368082}.
CC -!- SIMILARITY: Belongs to the KAR5 family. {ECO:0000256|ARBA:ARBA00010473,
CC ECO:0000256|RuleBase:RU368082}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PKY47653.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LLXI01000565; PKY47653.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2I1GLZ7; -.
DR VEuPathDB; FungiDB:FUN_014226; -.
DR VEuPathDB; FungiDB:GLOIN_2v1497325; -.
DR VEuPathDB; FungiDB:GLOIN_2v1497344; -.
DR VEuPathDB; FungiDB:RhiirA1_444124; -.
DR OrthoDB; 1365785at2759; -.
DR Proteomes; UP000234323; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0031965; C:nuclear membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0000742; P:karyogamy involved in conjugation with cellular fusion; IEA:UniProtKB-UniRule.
DR GO; GO:0048288; P:nuclear membrane fusion involved in karyogamy; IEA:UniProtKB-UniRule.
DR InterPro; IPR007292; Nuclear_fusion_Kar5.
DR PANTHER; PTHR28012; NUCLEAR FUSION PROTEIN KAR5; 1.
DR PANTHER; PTHR28012:SF1; NUCLEAR FUSION PROTEIN KAR5; 1.
DR Pfam; PF04163; Tht1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|RuleBase:RU368082};
KW Karyogamy {ECO:0000256|ARBA:ARBA00022459, ECO:0000256|RuleBase:RU368082};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368082};
KW Nucleus {ECO:0000256|RuleBase:RU368082};
KW Reference proteome {ECO:0000313|Proteomes:UP000234323};
KW Signal {ECO:0000256|RuleBase:RU368082};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368082};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368082}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT TRANSMEM 371..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT TRANSMEM 413..431
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368082"
FT COILED 281..340
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 450 AA; 52894 MW; D26D894D91A03252 CRC64;
MFAKKLKIIL MINYLIFFRL VFGVFGFNGW YLPKFLKFNE DSTFLLPMDD VNNDDSLGNL
SFLKFFEISN EERMIIEHGQ ASLTILEKKH DCFKEATTTL KNGCKNVNLS NNDKMQYAIR
LAKCELATAN LAFPMECDDF DHDVGKCIES ISRIPQFWTT YSGYFREVSQ MCFAMRYSLE
RDLLEEYNRN VTFKYHHILK HLHEIMMTLR KEEVKRLSQI KKFLTNMAKD VNELEETTSF
NMGSLKGILS DFQIITQSAL SQIIHLNEEL GKFVPNARII FDEINNANEQ QLSTIKELTN
KHDELLNQLQ EAKENLQNLL DISQNEIQEL TKSLSDAKKI HQDFMKFLKP LKVSIDFINW
IYDGKPFTNN VIYVIPLFTL IFWILFGKMV AISLTMQLLY RYINQYETFD EQFIQSFVLL
MTGGILSRVF SNGFENQMIT KILNIIRRRY
//
