ID   A0A2I1K972_9LACT        Unreviewed;       770 AA.
AC   A0A2I1K972;
DT   28-FEB-2018, integrated into UniProtKB/TrEMBL.
DT   28-FEB-2018, sequence version 1.
DT   24-JAN-2024, entry version 15.
DE   SubName: Full=DNA internalization-related competence protein ComEC/Rec2 {ECO:0000313|EMBL:PKY92159.1};
GN   ORFNames=CYJ27_01625 {ECO:0000313|EMBL:PKY92159.1};
OS   Aerococcus christensenii.
OC   Bacteria; Bacillota; Bacilli; Lactobacillales; Aerococcaceae; Aerococcus.
OX   NCBI_TaxID=87541 {ECO:0000313|EMBL:PKY92159.1, ECO:0000313|Proteomes:UP000234775};
RN   [1] {ECO:0000313|EMBL:PKY92159.1, ECO:0000313|Proteomes:UP000234775}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=UMB0844 {ECO:0000313|EMBL:PKY92159.1,
RC   ECO:0000313|Proteomes:UP000234775};
RA   Thomas-White K., Wolfe A.J.;
RT   "Phylogenetic diversity of female urinary microbiome.";
RL   Submitted (DEC-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PKY92159.1}.
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DR   EMBL; PKGZ01000001; PKY92159.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2I1K972; -.
DR   Proteomes; UP000234775; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0030420; P:establishment of competence for transformation; IEA:InterPro.
DR   CDD; cd07731; ComA-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   InterPro; IPR035681; ComA-like_MBL.
DR   InterPro; IPR004477; ComEC_N.
DR   InterPro; IPR004797; Competence_ComEC/Rec2.
DR   InterPro; IPR025405; DUF4131.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   NCBIfam; TIGR00360; ComEC_N-term; 1.
DR   NCBIfam; TIGR00361; ComEC_Rec2; 1.
DR   PANTHER; PTHR30619; DNA INTERNALIZATION/COMPETENCE PROTEIN COMEC/REC2; 1.
DR   PANTHER; PTHR30619:SF1; RECOMBINATION PROTEIN 2; 1.
DR   Pfam; PF03772; Competence; 1.
DR   Pfam; PF13567; DUF4131; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000234775};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..37
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        49..65
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..244
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        264..294
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        322..341
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..374
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        386..408
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        440..464
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        476..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          506..720
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   770 AA;  87971 MW;  68B27FB50D74FCEA CRC64;
     MKRVLIWVTI GYILEILLIF HGSMWEVGVL VYYVWLLEQK EDKKFLKKVL IYDALLLAFL
     MGYYWRLGSH FQEGRGTFIL EVPIHEVKVK GDLLQFMGRE VKSGEWLVSF YRLPQLEVKE
     SWLNRGQSLL IKVTGELKVP NAANNLGGFN YRQFLEREEI YWTLSVDRLQ ILGNMRGPLA
     VLSNVRKAIY CSLEGMGEPI IGNYVKALFF NERSGIDKEV MQSYQAIGII HLFSLSGFHV
     NYLLKLLKKT LLRIGVLREY YDWVALGVLG IYGTILGWPY GMFRAVGVYV LVFIQRRRKK
     RPHLLESICG VMLAHLLFKP QALFSLGFQL TYALSLGLFF VSQARDQWKN WQLTLGNALT
     CTLITLPFLI QTYASFNLLM VFANYFYAWL FTVILFPCLL LLAFGYWLGL GWMLSPLRGL
     VALGIQTTEA ISQEMITWEI FHVIIGYLPG ILVLVLVLGI GQWIDSFILR KNCRRTSLLL
     LGLLGALYAW PSLRPIGQVA MLNVGQGDCL MFQAPYSSRA YLIDACGLPS FPKEAWQERP
     IESLASREIT PTLRRQGIRS LAGIFLTHGD IDHYGSIPEL LKVWSVDNLY LPIGMKENTK
     VLRILKEGLK ASKNPKIQVH WLGKGQQLIL DKGQKVEVLM PDHIGQGKNE DSLALYAHLG
     QKTYLFTGDI GGEAERKMVD NLRRKKVDVL KVAHHGSDYS SPKDLLERIH PKVAWISVGK
     KNTYGHPSKR VIKNLKDLKV MVYRADQDGG THYFYSFLGG YFQCARENDQ
//